{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:32:07Z","timestamp":1791898327579,"version":"4.3.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.humimm.2024.110830","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:07:00Z","timestamp":1718060820000},"page":"110830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Mendelian randomization study investigating the causal relationships between inflammation and immunoglobulin A nephropathy"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-8889","authenticated-orcid":false,"given":"Yi","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-1135","authenticated-orcid":false,"given":"Honggang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2024.110830_b0005","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1056\/NEJMra1206793","article-title":"IgA nephropathy","volume":"368","author":"Wyatt","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2024.110830_b0010","doi-asserted-by":"crossref","first-page":"16001","DOI":"10.1038\/nrdp.2016.1","article-title":"IgA nephropathy","volume":"2","author":"Lai","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.humimm.2024.110830_b0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2215\/CJN.04820511","article-title":"Clinical features and outcomes of IgA nephropathy with nephrotic syndrome","volume":"7","author":"Kim","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0020","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s10157-019-01735-4","article-title":"Clinical and histological features and therapeutic strategies for IgA nephropathy","volume":"23","author":"Moriyama","year":"2019","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0025","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0272-6386(97)90333-4","article-title":"Natural history and risk factors for immunoglobulin A nephropathy in Japan","volume":"29","author":"Koyama","year":"1997","journal-title":"Research Group on Progressive Renal Diseases, Am J Kidney Dis"},{"key":"10.1016\/j.humimm.2024.110830_b0030","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.semnephrol.2018.05.013","article-title":"Epidemiology of IgA nephropathy: A global perspective","volume":"38","author":"Schena","year":"2018","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0035","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1681\/ASN.2018121255","article-title":"Mortality risk in IgA nephropathy","volume":"30","author":"Glassock","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0040","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1093\/ndt\/gfad082","article-title":"The incidence and prevalence of IgA nephropathy in Europe","volume":"38","author":"Willey","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.humimm.2024.110830_b0045","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1681\/ASN.2018101017","article-title":"Mortality in IgA nephropathy: A nationwide population-based cohort study","volume":"30","author":"Jarrick","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ki.2015.322","article-title":"Oxford derivation, north american validation and VALIGA consortia, oxford derivation north american validation and VALIGA consortia, The MEST score provides earlier risk prediction in lgA nephropathy","volume":"89","author":"Barbour","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.humimm.2024.110830_b0055","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00467-017-3628-1","article-title":"Inflammation in IgA nephropathy","volume":"32","author":"Rauen","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0060","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1053\/j.ajkd.2021.01.024","article-title":"IgA Nephropathy: Core curriculum 2021","volume":"78","author":"Pattrapornpisut","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.humimm.2024.110830_b0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4081\/nr.2012.e8","article-title":"A serum cytokine network in immunoglobulin a nephropathy","volume":"4","author":"Woo","year":"2012","journal-title":"Nephrology Research & Reviews"},{"key":"10.1016\/j.humimm.2024.110830_b0070","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11255-016-1444-3","article-title":"MicroRNA-155-induced T lymphocyte subgroup drifting in IgA nephropathy","volume":"49","author":"Yang","year":"2017","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0075","first-page":"186","article-title":"T lymphocytes in IgA nephropathy","volume":"20","author":"Tang","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.humimm.2024.110830_b0080","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1007\/s11255-021-03094-0","article-title":"New insights into pathogenesis of IgA nephropathy","volume":"54","author":"Xia","year":"2022","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0085","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng.787","article-title":"Genome-wide association study identifies susceptibility loci for IgA nephropathy","volume":"43","author":"Gharavi","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2024.110830_b0090","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1681\/ASN.2010010076","article-title":"HLA has strongest association with IgA nephropathy in genome-wide analysis","volume":"21","author":"Feehally","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0095","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ekir.2017.02.005","article-title":"What genetics tells us about the pathogenesis of iga nephropathy: The role of immune factors and infection","volume":"2","author":"Zhang","year":"2017","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.humimm.2024.110830_b0100","series-title":"Mendelian randomization: methods for causal inference using genetic variants","author":"Burgess","year":"2021"},{"key":"10.1016\/j.humimm.2024.110830_b0105","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: A review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res Synth Methods"},{"key":"10.1016\/j.humimm.2024.110830_b0110","doi-asserted-by":"crossref","first-page":"eabl4359","DOI":"10.1126\/sciadv.abl4359","article-title":"Causal effects of inflammatory protein biomarkers on inflammatory diseases","author":"Ek","year":"2021","journal-title":"Sci Adv 7"},{"key":"10.1016\/j.humimm.2024.110830_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.993716","article-title":"Gut-kidney axis in IgA nephropathy: Role on mesangial cell metabolism and inflammation","volume":"10","author":"Luvizotto","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.humimm.2024.110830_b0120","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2024.110830_b0125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2024.110830_b0130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13073-022-01032-y","article-title":"Milieu Int\u00e9rieur Consortium, Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes","volume":"14","author":"Caron","year":"2022","journal-title":"Genome Med"},{"key":"10.1016\/j.humimm.2024.110830_b0135","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1038\/s41598-017-10812-1","article-title":"Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations","volume":"7","author":"Prins","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.humimm.2024.110830_b0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajhg.2016.11.007","article-title":"Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors","volume":"100","author":"Ahola-Olli","year":"2017","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2024.110830_b0145","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","article-title":"Complex genetic signatures in immune cells underlie autoimmunity and inform therapy","volume":"52","author":"Orr\u00f9","year":"2020","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2024.110830_b0150","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/ije\/dyaa241","article-title":"Systemic inflammatory regulators and risk of Alzheimer\u2019s disease: a bidirectional Mendelian-randomization study","volume":"50","author":"Yeung","year":"2021","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.humimm.2024.110830_b0155","article-title":"Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: A Mendelian randomization","volume":"13","author":"Xiang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.humimm.2024.110830_b0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/0962280210394459","article-title":"Using multiple genetic variants as instrumental variables for modifiable risk factors","volume":"21","author":"Palmer","year":"2012","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.humimm.2024.110830_b0165","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.biopsych.2020.12.015","article-title":"High blood pressure and risk of dementia: A two-sample mendelian randomization study in the UK biobank","volume":"89","author":"Sproviero","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.humimm.2024.110830_b0170","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.humimm.2024.110830_b0175","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2024.110830_b0180","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/CM9.0000000000000613","article-title":"Homocysteine and IgA nephropathy: observational and Mendelian randomization analyses","volume":"133","author":"Zhang","year":"2020","journal-title":"Chin Med J (engl)"},{"key":"10.1016\/j.humimm.2024.110830_b0185","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2018.10.173","article-title":"Interleukin-7 stimulation inhibits nephrin activation and induces podocyte injury","volume":"507","author":"Zhai","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.humimm.2024.110830_b0190","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/biomedicines11010226","article-title":"Network-based assessment of minimal change disease identifies glomerular response to IL-7 and IL-12 pathways activation as innovative treatment target","volume":"11","author":"Eikrem","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.humimm.2024.110830_b0195","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3892\/etm.2011.322","article-title":"Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children","volume":"2","author":"Hahn","year":"2011","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.humimm.2024.110830_b0200","doi-asserted-by":"crossref","first-page":"1229636","DOI":"10.3389\/fimmu.2023.1229636","article-title":"Causal effects of systemic inflammatory regulators on chronic kidney diseases and renal function: a bidirectional Mendelian randomization study","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.humimm.2024.110830_b0205","doi-asserted-by":"crossref","first-page":"2002428","DOI":"10.1183\/13993003.02428-2020","article-title":"Targeted proteomics of right heart adaptation to pulmonary arterial hypertension","volume":"57","author":"Amsallem","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.humimm.2024.110830_b0210","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/s12886-020-01745-x","article-title":"Immunological biomarkers of the vitreous responsible for proliferative alteration in the different forms of retinal detachment","volume":"20","author":"Balogh","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.humimm.2024.110830_b0215","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/s11596-021-2409-z","article-title":"Interleukin-7 Is associated with clinical and pathological activities in immunoglobulin a nephropathy and protects the renal proximal tubule epithelium from cellular fibrosis","volume":"41","author":"Deng","year":"2021","journal-title":"Curr Med Sci"},{"issue":"23","key":"10.1016\/j.humimm.2024.110830_b0220","first-page":"00286","article-title":"Elevated levels of IL-6 in IgA nephropathy patients are induced by an epigenetically driven mechanism modulated by viral and bacterial RNA","volume":"S0953\u20136205","author":"Sallustio","year":"2023","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.humimm.2024.110830_b0225","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3389\/fimmu.2016.00604","article-title":"Hall of fame among pro-inflammatory cytokines: Interleukin-6 gene and its transcriptional regulation mechanisms","volume":"7","author":"Luo","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.humimm.2024.110830_b0230","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00011-010-0159-7","article-title":"Role of mast cells, stem cell factor and protease-activated receptor-2 in tubulointerstitial lesions in IgA nephropathy","volume":"59","author":"Liu","year":"2010","journal-title":"Inflamm Res"},{"key":"10.1016\/j.humimm.2024.110830_b0235","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s13730-022-00764-5","article-title":"IgA nephropathy diagnosed as a result of acute exacerbation due to G-CSF administration","volume":"12","author":"Hattori","year":"2023","journal-title":"CEN Case Rep"},{"key":"10.1016\/j.humimm.2024.110830_b0240","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/bmt.2015.224","article-title":"Exacerbation of IgA nephropathy following G-CSF administration for PBSC collection: suggestions for better donor screening","volume":"51","author":"Lee","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.humimm.2024.110830_b0245","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1182\/blood-2007-07-097543","article-title":"Biologic and molecular effects of granulocyte colony-stimulating factor in healthy individuals: recent findings and current challenges","volume":"111","author":"Anderlini","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2024.110830_b0250","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1681\/ASN.2016010061","article-title":"Filgrastim-induced crescentic transformation of recurrent IgG2\u03bb GN","volume":"27","author":"Batal","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0255","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12882-018-1049-4","article-title":"Development of membranoproliferative glomerulonephritis-like glomerulopathy in a patient with neutrophilia resulting from endogenous granulocyte-colony stimulating factor overproduction: a case report","volume":"19","author":"Ito","year":"2018","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0260","doi-asserted-by":"crossref","first-page":"e15448","DOI":"10.14814\/phy2.15448","article-title":"Can mobilization of bone marrow stem cells be an alternative regenerative therapy to stem cell injection in a rat model of chronic kidney disease?","volume":"10","author":"Morsy","year":"2022","journal-title":"Physiol Rep"},{"key":"10.1016\/j.humimm.2024.110830_b0265","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3390\/ijms21041389","article-title":"Immunological pattern in IgA nephropathy","volume":"21","author":"Esteve Cols","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.humimm.2024.110830_b0270","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000044941","article-title":"Anti-CD8 monoclonal antibody protects against spontaneous IgA nephropathy in ddY mice","volume":"78","author":"Shimamine","year":"1998","journal-title":"Nephron"},{"key":"10.1016\/j.humimm.2024.110830_b0275","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/s41581-021-00466-8","article-title":"Unconventional T cells and kidney disease","volume":"17","author":"Kaminski","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.humimm.2024.110830_b0280","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1111\/jcmm.16407","article-title":"A single-cell survey of the human glomerulonephritis","volume":"25","author":"Chen","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.humimm.2024.110830_b0285","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/cells9030531","article-title":"Memory CD4+ T cells in immunity and autoimmune diseases","volume":"9","author":"Raphael","year":"2020","journal-title":"Cells"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924000909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924000909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T20:36:19Z","timestamp":1721939779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885924000909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0198885924000909"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2024.110830","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Mendelian randomization study investigating the causal relationships between inflammation and immunoglobulin A nephropathy","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2024.110830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110830"}}