{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:43:21Z","timestamp":1790729001885,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.humimm.2024.111162","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T19:57:22Z","timestamp":1729713442000},"page":"111162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rational design of novel peptide-based vaccine against the emerging OZ virus"],"prefix":"10.1016","volume":"85","author":[{"given":"Fizza","family":"Arshad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asifa","family":"Sarfraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleeza","family":"Rubab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Shehroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlindo A.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheheryar","family":"Sheheryar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riaz","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaaty A.","family":"Shahat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Nishan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohibullah","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1981","key":"10.1016\/j.humimm.2024.111162_b0005","first-page":"65","article-title":"Amblyomma testudinarium Koch, 1844: discovery and record in Korea, and identification and redescription of male tick","volume":"21","author":"Kang","year":"1844","journal-title":"Korean J. Vet. Res."},{"key":"10.1016\/j.humimm.2024.111162_b0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.virusres.2018.03.004","article-title":"Characterization of a novel thogotovirus isolated from Amblyomma testudinarium ticks in Ehime, Japan: a significant phylogenetic relationship to Bourbon virus","volume":"249","author":"Ejiri","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.humimm.2024.111162_b0015","unstructured":"National Institute of Infectious Diseases, Oz Virus Infection in Human, 2023, pp. 1\u20133, Www.Niid.Go.Jp."},{"key":"10.1016\/j.humimm.2024.111162_b0020","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s00705-013-1688-5","article-title":"Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses","volume":"158","author":"Adams","year":"2013","journal-title":"Arch. Virol."},{"key":"10.1016\/j.humimm.2024.111162_b0025","doi-asserted-by":"crossref","DOI":"10.1017\/S0031182004005220","article-title":"Tick-borne viruses","volume":"129","author":"Labuda","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.humimm.2024.111162_b0030","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3201\/eid2105.150150","article-title":"Novel Thogotovirus associated with febrile illness and death, United States, 2014","volume":"21","author":"Kosoy","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.humimm.2024.111162_b0035","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/0042-6822(92)90030-S","article-title":"The glycoprotein of Thogoto virus (a tick-borne orthomyxo-like virus) is related to the baculovirus glycoprotein GP64","volume":"186","author":"Morse","year":"1992","journal-title":"Virology"},{"key":"10.1016\/j.humimm.2024.111162_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2020.101413","article-title":"Transforming vaccine development","volume":"50","author":"Black","year":"2020","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.molimm.2014.04.009","article-title":"In silico predicted mycobacterial epitope elicits in vitro T-cell responses","volume":"61","author":"Khan","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0050","doi-asserted-by":"crossref","first-page":"16258","DOI":"10.1038\/s41598-020-73179-w","article-title":"In silico analysis and in vivo assessment of a novel epitope-based vaccine candidate against uropathogenic Escherichia coli","volume":"10","author":"Hasanzadeh","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2024.111162_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08820139.2020.1867163","article-title":"In silico and in vivo analysis of HIV-1 rev regulatory protein for evaluation of a multiepitope-based vaccine candidate","volume":"51","author":"Shabani","year":"2022","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.humimm.2024.111162_b0060","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.3390\/molecules26206182","article-title":"In silico and in vivo evaluation of SARS-CoV-2 predicted epitopes-based candidate vaccine","volume":"26","author":"Shehata","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.humimm.2024.111162_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1281544","article-title":"Development of a subunit vaccine against the cholangiocarcinoma causing Opisthorchis viverrini: a computational approach","volume":"15","author":"Shah","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0070","doi-asserted-by":"crossref","first-page":"43341","DOI":"10.1021\/acsomega.3c07866","article-title":"Deciphering the immunogenicity of monkeypox proteins for designing the potential mRNA vaccine","volume":"8","author":"Shah","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.humimm.2024.111162_b0075","doi-asserted-by":"crossref","first-page":"111952","DOI":"10.1016\/j.intimp.2024.111952","article-title":"Decrypting the multi-genome data for chimeric vaccine designing against the antibiotic resistant Yersinia pestis","volume":"132","author":"Sarfraz","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.humimm.2024.111162_b0080","first-page":"2778","article-title":"Genome-wide core proteome analysis of brucella melitensis strains for potential drug target prediction, mini-reviews in medicinal","volume":"21","author":"Rahman","year":"2020","journal-title":"Chemistry"},{"key":"10.1016\/j.humimm.2024.111162_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2021.564056","article-title":"Genome-based drug target identification in human pathogen streptococcus gallolyticus","volume":"12","author":"Qureshi","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.humimm.2024.111162_b0090","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.humimm.2024.111162_b0095","doi-asserted-by":"crossref","unstructured":"E. Gasteiger, C. Hoogland, A. Gattiker, S. Duvaud, M.R. Wilkins, R.D. Appel, A. Bairoch, Protein identification and analysis tools on the ExPASy Server, in: The Proteomics Protocols Handbook, Humana Press, Totowa, NJ, 2005, pp. 571\u2013607. doi: 10.1385\/1-59259-890-0:571.","DOI":"10.1385\/1-59259-890-0:571"},{"key":"10.1016\/j.humimm.2024.111162_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19137723","article-title":"Computer-aided multi-epitope vaccine design against enterobacter xiangfangensis","volume":"19","author":"Alshammari","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.humimm.2024.111162_b0105","doi-asserted-by":"crossref","first-page":"e36153","DOI":"10.1016\/j.heliyon.2024.e36153","article-title":"Genome-level therapeutic targets identification and chimeric Vaccine designing against the Blastomyces dermatitidis","volume":"10","author":"Mursaleen","year":"2024","journal-title":"Heliyon"},{"issue":"2019","key":"10.1016\/j.humimm.2024.111162_b0110","first-page":"D339","article-title":"The Immune Epitope Database (IEDB): 2018 update","volume":"47","author":"Vita","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111162_b0115","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/nar\/gkn254","article-title":"Immune epitope database analysis resource (IEDB-AR)","volume":"36","author":"Zhang","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111162_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1291868","article-title":"Designing a polyvalent vaccine targeting multiple strains of varicella zoster virus using integrated bioinformatics approaches","volume":"14","author":"Amin Rani","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.humimm.2024.111162_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0285177","article-title":"In silico design and validation of a novel multiepitope vaccine candidate against structural proteins of Chikungunya virus using comprehensive immunoinformatics analyses","volume":"18","author":"Mahmoodi","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2024.111162_b0130","first-page":"1","article-title":"Structural informatics approach for designing an epitope-based vaccine against the brain-eating Naegleria fowleri","volume":"14","author":"Sarfraz","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104701","article-title":"Chlamydia trachomatis core genome data mining for promising novel drug targets and chimeric vaccine candidates identification","volume":"136","author":"Aslam","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.humimm.2024.111162_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073957","article-title":"In silico approach for predicting toxicity of peptides and proteins","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2024.111162_b0145","doi-asserted-by":"crossref","DOI":"10.1007\/s00894-014-2278-5","article-title":"AllerTOP vol 2 - a server for in silico prediction of allergens","volume":"20","author":"Dimitrov","year":"2014","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.humimm.2024.111162_b0150","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.micpath.2018.09.033","article-title":"Reverse vaccinology and subtractive genomics-based putative vaccine targets identification for Burkholderia pseudomallei Bp1651","volume":"125","author":"Hizbullah","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.humimm.2024.111162_b0155","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3390\/vaccines10091476","article-title":"mRNA vaccine designing using chikungunya virus E glycoprotein through immunoinformatics-guided approaches","volume":"10","author":"Jaan","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.humimm.2024.111162_b0160","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1038\/s41596-021-00628-9","article-title":"The trRosetta server for fast and accurate protein structure prediction","volume":"16","author":"Du","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.humimm.2024.111162_b0165","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.drudis.2020.03.006","article-title":"Epitope-based vaccine design: a comprehensive overview of bioinformatics approaches","volume":"25","author":"Parvizpour","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.humimm.2024.111162_b0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.meegid.2017.12.008","article-title":"Structural vaccinology considerations for in silico designing of a multi-epitope vaccine","volume":"58","author":"Negahdaripour","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.humimm.2024.111162_b0175","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00465-24","article-title":"Designing a smallpox B-cell and T-cell multi-epitope subunit vaccine using a comprehensive immunoinformatics approach","volume":"12","author":"Yu","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.humimm.2024.111162_b0180","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.4049\/jimmunol.168.11.5499","article-title":"A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes","volume":"168","author":"Livingston","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125068","article-title":"Designing a multi-epitopes subunit vaccine against human herpes virus 6A based on molecular dynamics and immune stimulation","volume":"244","author":"Suleman","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.humimm.2024.111162_b0190","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/nar\/gks400","article-title":"ExPASy: SIB bioinformatics resource portal","volume":"40","author":"Artimo","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111162_b0195","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1756-0500-2-111","article-title":"A comprehensive resource for integrating and displaying protein post-translational modifications","volume":"2","author":"Lee","year":"2009","journal-title":"BMC. Res. Notes"},{"key":"10.1016\/j.humimm.2024.111162_b0200","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/bioinformatics\/11.6.681","article-title":"Sopma: Significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments","volume":"11","author":"Geourjon","year":"1995","journal-title":"Bioinformatics"},{"key":"10.1016\/j.humimm.2024.111162_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-023-05183-6","article-title":"Immunoinformatics design of multi-epitope vaccine using OmpA, OmpD and enterotoxin against non-typhoidal salmonellosis","volume":"24","author":"Beikzadeh","year":"2023","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.humimm.2024.111162_b0210","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.vaccine.2021.01.011","article-title":"Immuno-informatics approach for B-cell and T-cell epitope based peptide vaccine design against novel COVID-19 virus","volume":"39","author":"Singh","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.humimm.2024.111162_b0215","doi-asserted-by":"crossref","first-page":"W294","DOI":"10.1093\/nar\/gks493","article-title":"GalaxyWEB server for protein structure prediction and refinement","volume":"40","author":"Ko","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111162_b0220","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/nar\/gkt458","article-title":"GalaxyRefine: protein structure refinement driven by side-chain repacking","volume":"41","author":"Heo","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111162_b0225","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.ygeno.2019.10.009","article-title":"Potential druggable proteins and chimeric vaccine construct prioritization against Brucella melitensis from species core genome data","volume":"112","author":"Aslam","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.humimm.2024.111162_b0230","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.humimm.2024.111162_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.humimm.2024.111162_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10989-021-10316-7","article-title":"In-silico vaccine design based on a novel vaccine candidate against infections caused by acinetobacter baumannii","volume":"28","author":"Khalid","year":"2022","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.humimm.2024.111162_b0245","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.micpath.2012.08.008","article-title":"Essential role of toll-like receptor 4 in Acinetobacter baumannii-induced immune responses in immune cells","volume":"54","author":"Kim","year":"2013","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.humimm.2024.111162_b0250","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1002\/prot.24403","article-title":"How good is automated protein docking?","volume":"81","author":"Kozakov","year":"2013","journal-title":"Proteins: Struct., Funct., Bioinform."},{"key":"10.1016\/j.humimm.2024.111162_b0255","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/bmb.20966","article-title":"Using the PyMOL application to reinforce visual understanding of protein structure","volume":"44","author":"Rigsby","year":"2016","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.humimm.2024.111162_b0260","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/pro.2449","article-title":"Contribution of hydrogen bonds to protein stability","volume":"23","author":"Pace","year":"2014","journal-title":"Protein Sci."},{"key":"10.1016\/j.humimm.2024.111162_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.crstbi.2020.11.002","article-title":"Peptide bond planarity constrains hydrogen bond geometry and influences secondary structure conformations","volume":"3","author":"Tan","year":"2021","journal-title":"Curr. Res. Struct. Biol."},{"key":"10.1016\/j.humimm.2024.111162_b0270","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01151-22","article-title":"Immunoinformatics approach to design novel subunit vaccine against the epstein-barr virus","volume":"10","author":"Moin","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.humimm.2024.111162_b0275","doi-asserted-by":"crossref","first-page":"16262","DOI":"10.1021\/acsomega.3c10351","article-title":"Identification of novel quinolone and quinazoline alkaloids as phosphodiesterase 10A inhibitors for Parkinson\u2019s disease through a computational approach","volume":"9","author":"Ahmad","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.humimm.2024.111162_b0280","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0010-4655(96)00016-1","article-title":"Ewald summation techniques in perspective: a survey","volume":"95","author":"Toukmaji","year":"1996","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.humimm.2024.111162_b0285","doi-asserted-by":"crossref","DOI":"10.1063\/1.2018637","article-title":"Structural properties of water: comparison of the SPC, SPCE, TIP4P, and TIP5P models of water","volume":"123","author":"Zielkiewicz","year":"2005","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.humimm.2024.111162_b0290","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1063\/1.463940","article-title":"Nos\u00e9-Hoover chains: the canonical ensemble via continuous dynamics","volume":"97","author":"Martyna","year":"1992","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.humimm.2024.111162_b0295","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111162_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/msb.20209478","article-title":"Slower growth of Escherichia coli leads to longer survival in carbon starvation due to a decrease in the maintenance rate","volume":"16","author":"Biselli","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.humimm.2024.111162_b0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2023.1123411","article-title":"Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine against Klebsiella pneumoniae and Pseudomonas aeruginosa coinfection","volume":"10","author":"Gouda","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.humimm.2024.111162_b0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009862","article-title":"Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system","volume":"5","author":"Rapin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2024.111162_b0315","unstructured":"F. Castiglione, M. Bernaschi, C-immsim: playing with the immune response, Proceedings of the Sixteenth \u2026 (2004) 1\u20137."},{"key":"10.1016\/j.humimm.2024.111162_b0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-40833-x","article-title":"In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases","volume":"9","author":"Shey","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2024.111162_b0325","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1172\/JCI29838","article-title":"Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting","volume":"117","author":"Guan","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.humimm.2024.111162_b0330","doi-asserted-by":"crossref","DOI":"10.1172\/JCI35112","article-title":"Growth hormone resurrects adult human thymus during HIV-1 infection","author":"Tesselaar","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.humimm.2024.111162_b0335","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.2147\/DDDT.S136957","article-title":"Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli","volume":"11","author":"Setrerrahmane","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.humimm.2024.111162_b0340","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.humimm.2024.111162_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0043674","article-title":"CD8 T cell epitope distribution in viruses reveals patterns of protein biosynthesis","volume":"7","author":"Diez-Rivero","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2024.111162_b0350","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1128\/JVI.03391-13","article-title":"Upolu virus and aransas bay virus, two presumptive bunyaviruses, are novel members of the family orthomyxoviridae","volume":"88","author":"Briese","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.humimm.2024.111162_b0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/2680160","article-title":"Fundamentals and methods for T- and B-cell epitope prediction","volume":"2017","author":"Sanchez-Trincado","year":"2017","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.humimm.2024.111162_b0360","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12026-022-09284-x","article-title":"Reverse vaccinology approach to design a multi-epitope vaccine construct based on the Mycobacterium tuberculosis biomarker PE_PGRS17","volume":"70","author":"Moodley","year":"2022","journal-title":"Immunol. Res."},{"key":"10.1016\/j.humimm.2024.111162_b0365","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.863234","article-title":"Immunoinformatic design of a multivalent peptide vaccine against mucormycosis: targeting FTR1 protein of major causative fungi","volume":"13","author":"Araf","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0370","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.autrev.2005.04.005","article-title":"CD4+ regulatory T cells: mechanisms of induction and effector function","volume":"4","author":"Bacchetta","year":"2005","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.humimm.2024.111162_b0375","doi-asserted-by":"crossref","first-page":"12814","DOI":"10.3390\/ijms222312814","article-title":"Pan-genome reverse vaccinology approach for the design of multi-epitope vaccine construct against Escherichia albertii","volume":"22","author":"Jalal","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.humimm.2024.111162_b0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/925135","article-title":"CD4 + T cells: differentiation and functions","volume":"2012","author":"Luckheeram","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0385","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00171","article-title":"T cell responses to viral infections \u00e2\u20ac\u201c opportunities for peptide vaccination","volume":"5","author":"Rosendahl Huber","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0390","doi-asserted-by":"crossref","first-page":"e0286224","DOI":"10.1371\/journal.pone.0286224","article-title":"In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus","volume":"18","author":"Sanami","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2024.111162_b0395","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.fsi.2022.03.017","article-title":"\u03b2-Defensin: an adroit saviour in teleosts","volume":"123","author":"Das","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.humimm.2024.111162_b0400","doi-asserted-by":"crossref","first-page":"e6185","DOI":"10.7717\/peerj.6185","article-title":"Application of built-in adjuvants for epitope-based vaccines","volume":"6","author":"Lei","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.humimm.2024.111162_b0405","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/14760584.2018.1457443","article-title":"Flagellin as a vaccine adjuvant","volume":"17","author":"Cui","year":"2018","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.humimm.2024.111162_b0410","doi-asserted-by":"crossref","first-page":"45","DOI":"10.15171\/bi.2019.06","article-title":"In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens","volume":"9","author":"Parvizpour","year":"2018","journal-title":"Bioimpacts"},{"key":"10.1016\/j.humimm.2024.111162_b0415","series-title":"Protein Modificomics","first-page":"1","article-title":"Posttranslational modifications of proteins and their role in biological processes and associated diseases","author":"Tak","year":"2019"},{"key":"10.1016\/j.humimm.2024.111162_b0420","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3892\/ijmm.2017.3036","article-title":"The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)","volume":"40","author":"Ardito","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.humimm.2024.111162_b0425","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1083\/jcb.201706135","article-title":"N -Glycan\u2013dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing","volume":"217","author":"Liu","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.humimm.2024.111162_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2021.151186","article-title":"Advances in understanding N-glycosylation structure, function, and regulation in health and disease","volume":"100","author":"Esmail","year":"2021","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.humimm.2024.111162_b0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100964","article-title":"The role of O-glycosylation in human disease","volume":"79","author":"Magalh\u00e3es","year":"2021","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.humimm.2024.111162_b0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14760584.2022.1997600","article-title":"The potential of intrinsically disordered regions in vaccine development","volume":"21","author":"Ameri","year":"2022","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.humimm.2024.111162_b0445","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/9914854","article-title":"Toll-like receptors: general molecular and structural biology","volume":"2021","author":"Behzadi","year":"2021","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.humimm.2024.111162_b0450","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.706510","article-title":"Blockade of TLR2 and TLR4 attenuates inflammatory response and parasite load in cutaneous leishmaniasis","volume":"12","author":"Carneiro","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924004257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924004257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T01:36:03Z","timestamp":1733880963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885924004257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0198885924004257"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2024.111162","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rational design of novel peptide-based vaccine against the emerging OZ virus","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2024.111162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111162"}}