{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:04:09Z","timestamp":1790420649737,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.humimm.2024.111164","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T22:38:11Z","timestamp":1729723091000},"page":"111164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the influence of inflammasome complex genes on Turner syndrome"],"prefix":"10.1016","volume":"85","author":[{"given":"Raysa","family":"Samanta Moraes Laranjeira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Eduarda de Albuquerque Borborema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldianne","family":"Milene dos Santos Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Vieira de Barros Arcoverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Albertina Dantas de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"de Rezende Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Guiomar Sales Gomes da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline","family":"de Azev\u00eado Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neide","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2024.111164_b0005","first-page":"lvae050","article-title":"Clinical Practice Guidelines for the Care of Girls and Women with Turner Syndrome","author":"Gravholt","year":"2024","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.humimm.2024.111164_b0010","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/art.27270","article-title":"Autoimmune diseases in women with Turner\u2019s syndrome","volume":"62","author":"J\u00f8rgensen","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.humimm.2024.111164_b0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13052-015-0146-2","article-title":"Peculiarities of autoimmune thyroid diseases in children with Turner or Down syndrome: an overview","volume":"41","author":"Aversa","year":"2015","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.humimm.2024.111164_b0020","doi-asserted-by":"crossref","unstructured":"Invernizzi P, Miozzo M, Selmi C, Persani L, Battezzati PM, Zuin M et al. X chromosome monosomy: a common mechanism for autoimmune diseases. J Immunol. 2005. 175: 575\u20138. 0.4049\/jimmunol.175.1.575.","DOI":"10.4049\/jimmunol.175.1.575"},{"key":"10.1016\/j.humimm.2024.111164_b0025","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jaut.2012.01.015","article-title":"Autoimmune disorders in women with turner syndrome and women with karyotypically nor-mal primary ovarian insufficiency","volume":"38","author":"Bakalov","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.humimm.2024.111164_b0030","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imr.12607","article-title":"The NLRC4 inflammasome","volume":"281","author":"Duncan","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.humimm.2024.111164_b0035","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1161\/ATVBAHA.111.224907","article-title":"Cell death, damage-associated molecular patterns, and sterile inflflammation in cardiovascular disease","volume":"31","author":"Zheng","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.humimm.2024.111164_b0040","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.atherosclerosis.2009.12.017","article-title":"Caspase-1 recognizes extended cleavage sites in its naturais substrates","volume":"210","author":"Shen","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.humimm.2024.111164_b0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fnins.2014.00315","article-title":"Inflammasomes in neuroinflammation and changes in brain function: a focused review","volume":"8","author":"Singhal","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.humimm.2024.111164_b0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nrn3638","article-title":"Inflammasomes in the CNS","volume":"15","author":"Walsh","year":"2014","journal-title":"Nature Rev. Neurosci."},{"key":"10.1016\/j.humimm.2024.111164_b0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/jcbfm.2013.227","article-title":"Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury","volume":"34","author":"De Rivero Vaccari","year":"2014","journal-title":"J Cereb Blood Flow Metab."},{"key":"10.1016\/j.humimm.2024.111164_b0060","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The Inflflammasome: A Molecular Platform Triggering Activation of Inflflammatory Caspases and Processing of proILBeta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell."},{"key":"10.1016\/j.humimm.2024.111164_b0065","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1189\/jlb.0512265","article-title":"Redox control of NLRP3 inflammasome activation in health and disease","volume":"92","author":"Rubartelli","year":"2019","journal-title":"J Leukoc Biol."},{"key":"10.1016\/j.humimm.2024.111164_b0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.clim.2012.12.006","article-title":"Specific inflammasomes in complex diseases","volume":"143","author":"Masters","year":"2013","journal-title":"Clin Immunol."},{"key":"10.1016\/j.humimm.2024.111164_b0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1741-7015-11-100","article-title":"Requirements for innate immune pathways in environmentally induced autoimmunity","volume":"11","author":"Pollard","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.humimm.2024.111164_b0080","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3109\/08916930903540432","article-title":"Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil","volume":"43","author":"Pontillo","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/j.humimm.2024.111164_b0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/gene.2010.11","article-title":"Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn\u2019s disease","volume":"11","author":"Roberts","year":"2010","journal-title":"Genes Immun."},{"key":"10.1016\/j.humimm.2024.111164_b0090","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med."},{"key":"10.1016\/j.humimm.2024.111164_b0095","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00011-017-1119-2","article-title":"Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients","volume":"67","author":"Addobbati","year":"2017","journal-title":"Inflamm Res."},{"key":"10.1016\/j.humimm.2024.111164_b0100","article-title":"Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis","volume":"106","author":"Wu","year":"2019","journal-title":"J Autoimmun."},{"key":"10.1016\/j.humimm.2024.111164_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109313","article-title":"Let-7f-5p ameliorates inflammation by targeting NLRP3 in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus","volume":"118","author":"Tan","year":"2019","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.humimm.2024.111164_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172795","article-title":"Contribution of cathepsin B dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction","volume":"865","author":"Zhang","year":"2019","journal-title":"Eur J Pharmacol."},{"key":"10.1016\/j.humimm.2024.111164_b0115","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/gene.2008.85","article-title":"A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes","volume":"10","author":"Magitta","year":"2009","journal-title":"Genes Immun."},{"key":"10.1016\/j.humimm.2024.111164_b0120","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MCG.0b013e3181faec51","article-title":"Interleukin 1 \u03b2 (IL1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with thegenetic susceptibility and steroid dependence in patients with ulcerative colitis","volume":"45","author":"Yamamoto-Furusho","year":"2011","journal-title":"J Clin Gastroenterol."},{"key":"10.1016\/j.humimm.2024.111164_b0125","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/dna.2013.2204","article-title":"Association between the interleukin-1\u03b2 Gene (IL1B) C-511T polymorphism and the risk of diabetic nephropathy in type 2 diabetes: a candidate-gene association study","volume":"33","author":"Stefanidis","year":"2014","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.humimm.2024.111164_b0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.patbio.2015.04.004","article-title":"Interleukin-1\u03b2, Interleukin1-Ra, Interleukin-10, and tumor necrosis factor-\u03b1 polymorphisms in Tunisian patients with rheumatoid arthritis","volume":"63","author":"Lagha","year":"2015","journal-title":"Pathol Biol (paris)"},{"key":"10.1016\/j.humimm.2024.111164_b0135","doi-asserted-by":"crossref","unstructured":"Tripathi AK, Shukla S, Tripathi JK, Saket RD, Kol S, Mishra P, Chauhan UK, and Indurkar M. Association of Genetic Polymorphism of Infammatory Genes (IL1B and IL-4) with Diabetes Type 2. J Genet Mol Cell Biol. 2015; 1: 004. 10.18650\/2379-5700.21001.","DOI":"10.18650\/2379-5700.21001"},{"key":"10.1016\/j.humimm.2024.111164_b0140","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1002\/jcb.26667","article-title":"Biochemical and Molecular Study on Interleukin-1\u03b2 Gene Expression and Relation of Single Nucleotide Polymorphism in Promoter region with Type 2 Diabetes Mellitus","volume":"119","author":"Tayel","year":"2018","journal-title":"J Cell Biochem."},{"key":"10.1016\/j.humimm.2024.111164_b0145","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1002\/art.20310","article-title":"Correlation of Polymorphic Variation in the Promoter Region of the Interleukin-1_Gene With Secretion of Interleukin-1_Protein","volume":"50","author":"Hall","year":"2004","journal-title":"Arthritis & Rheum"},{"key":"10.1016\/j.humimm.2024.111164_b0150","doi-asserted-by":"crossref","unstructured":"Hitomi Y, Ebisawa M, Tomikawa M, Imai T, Komata T, Hirota T, Harada M, Sakashita M, Suzuki Y, Shimojo N et al. Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol. 2009; 124: 779-85.e6. 10.1016\/j.jaci.2009.07.044.","DOI":"10.1016\/j.jaci.2009.07.044"},{"key":"10.1016\/j.humimm.2024.111164_b0155","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.humimm.2024.111164_b0160","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"4","author":"Bustin","year":"2009","journal-title":"Clin Chem."},{"key":"10.1016\/j.humimm.2024.111164_b0165","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/bioinformatics\/btl268","article-title":"SNPStats: a web tool for the analysis of association studies","volume":"22","author":"Sol\u00e9","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.humimm.2024.111164_b0170","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.humimm.2024.111164_b0175","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00011-014-0774-9","article-title":"NLRP3 gene is associated with ulcerative colitis (UC), but not Crohn\u2019s disease (CD), in Chinese Han population","volume":"63","author":"Zhang","year":"2014","journal-title":"Inflamm Res."},{"key":"10.1016\/j.humimm.2024.111164_b0180","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1089\/thy.2013.0452","article-title":"In young patients with Turner or Down syndrome, Graves\u2019 disease presentation is often preceded by Hashimoto\u2019s thyroiditis","volume":"24","author":"Aversa","year":"2014","journal-title":"Thyroid"},{"key":"10.1016\/j.humimm.2024.111164_b0185","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fendo.2018.00307","article-title":"Immunological profile and predisposition to autoimmunity in girls with Turner Syndrome","volume":"9","author":"Gawlik","year":"2018","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.humimm.2024.111164_b0190","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-3083.2010.02438.x","article-title":"PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome","volume":"72","author":"Bianco","year":"2010","journal-title":"Scand J Immunol."},{"key":"10.1016\/j.humimm.2024.111164_b0195","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3109\/09513590.2011.631630","article-title":"Analysisofvitamin D receptor gene (VDR) polymorphisms in Turner syndromepatients","volume":"28","author":"Bianco","year":"2012","journal-title":"Gynecol Endocrinol."},{"key":"10.1016\/j.humimm.2024.111164_b0200","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1590\/1678-4685-gmb-2017-0312","article-title":"CTLA-4 gene polymorphisms are associated with obesity in Turner Syndrome","volume":"41","author":"Santos","year":"2018","journal-title":"Genet Mol Biol."},{"key":"10.1016\/j.humimm.2024.111164_b0205","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s40618-019-01135-1","article-title":"Vitamin D receptor (VDR) gene polymorphisms and expression profile influence upon the immunological imbalance in Turner syndrome","volume":"43","author":"Santos","year":"2019","journal-title":"J Endocrinol Invest."},{"key":"10.1016\/j.humimm.2024.111164_b0210","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2337\/db12-0420","article-title":"Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes","volume":"62","author":"Lee","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.humimm.2024.111164_b0215","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00011-017-1119-2","article-title":"Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients","volume":"67","author":"Addobbati","year":"2018","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.humimm.2024.111164_b0220","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3389\/fimmu.2018.01197","article-title":"Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis","volume":"9","author":"Guo","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2024.111164_b0225","first-page":"5463","article-title":"NLRP1 and NLRP3 inflammasomes mediate LPS\/ATP-induced pyroptosis in knee osteoarthritis","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924004270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924004270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T01:35:55Z","timestamp":1733880955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885924004270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0198885924004270"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2024.111164","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the influence of inflammasome complex genes on Turner syndrome","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2024.111164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111164"}}