{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:10:55Z","timestamp":1786990255833,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.humimm.2024.111218","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T20:59:13Z","timestamp":1734123553000},"page":"111218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of a novel immunosenescence-related genes and integrative analyses in patients with psoriasis"],"prefix":"10.1016","volume":"86","author":[{"given":"Yiran","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10281","key":"10.1016\/j.humimm.2024.111218_bb0005","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000515767","article-title":"Dermal Mesenchymal Stem Cells from Psoriatic Lesions Stimulate HaCaT Cell Proliferation, Differentiation, and Migration via Activating the PI3K\/AKT Signaling Pathway","volume":"238","author":"Liang","year":"2022","journal-title":"Dermatology"},{"issue":"4","key":"10.1016\/j.humimm.2024.111218_bb0015","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/bjd.18245","article-title":"Management of psoriasis as a systemic disease: what is the evidence?","volume":"182","author":"Korman","year":"2020","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.humimm.2024.111218_bb0020","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/jdv.18044","article-title":"Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis","volume":"36","author":"Wu","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"5","key":"10.1016\/j.humimm.2024.111218_bb0025","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s12325-020-01346-6","article-title":"Psoriasis and Cardiovascular Risk: A Comprehensive Review","volume":"37","author":"Masson","year":"2020","journal-title":"Adv. Ther."},{"issue":"6","key":"10.1016\/j.humimm.2024.111218_bb0030","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/1346-8138.15840","article-title":"Psoriasis: Comorbidities","volume":"48","author":"Yamazaki","year":"2021","journal-title":"J. Dermatol."},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0035","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/jdv.18720","article-title":"Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review","volume":"37","author":"Prinz","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"5","key":"10.1016\/j.humimm.2024.111218_bb0040","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/ijd.14864","article-title":"Global burden of psoriasis - comparison of regional and global epidemiology, 1990 to 2017","volume":"59","author":"AlQassimi","year":"2020","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.humimm.2024.111218_bb0045","article-title":"Immunosenescence, aging and successful aging","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.humimm.2024.111218_bb0050","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Sig. Trans.Targeted Therapy"},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0055","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/imm.13152","article-title":"Skin barrier immunity and ageing","volume":"160","author":"Chambers","year":"2020","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.humimm.2024.111218_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097956","article-title":"Immunosenescence and Skin: A State of Art of Its Etiopathogenetic Role and Crucial Watershed for Systemic Implications","volume":"24","author":"Papa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0065","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/bjd.19169","article-title":"Systematic review examining changes over time and variation in the incidence and prevalence of psoriasis by age and gender","volume":"184","author":"Iskandar","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0070","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1177\/1203475419897578","article-title":"Biologic Treatment in Elderly Patients With Psoriasis: A Systematic Review","volume":"24","author":"Sandhu","year":"2020","journal-title":"J. Cutan. Med. Surg."},{"issue":"11","key":"10.1016\/j.humimm.2024.111218_bb0075","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1111\/exd.14932","article-title":"A 2-week time-restricted feeding attenuates psoriasis-like lesions with reduced inflammatory cytokines and immunosenescence in mice","volume":"32","author":"Chen","year":"2023","journal-title":"Exp. Dermatol."},{"issue":"9","key":"10.1016\/j.humimm.2024.111218_bb0080","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.ad.2023.05.016","article-title":"Moderate to Severe Psoriasis in Older Adults: Recommendations on Management from the Psoriasis Working Group of the Spanish Academy of Dermatology and Venereology (AEDV)","volume":"114","author":"Mataix","year":"2023","journal-title":"Actas Dermosifiliogr."},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0085","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jid.2016.09.015","article-title":"Shrinking the psoriasis assessment gap: early gene-expression Profiling accurately predicts response to long-term treatment","volume":"137","author":"Correa da Rosa","year":"2017","journal-title":"J. Investigat. Dermatol."},{"issue":"7","key":"10.1016\/j.humimm.2024.111218_bb0090","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1172\/JCI98219","article-title":"Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation","volume":"128","author":"Mande","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.humimm.2024.111218_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002737","article-title":"Type I interferon: potential therapeutic target for psoriasis?","volume":"3","author":"Yao","year":"2008","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.humimm.2024.111218_bb0100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jdermsci.2023.01.003","article-title":"Psoriasis improvements and inflammatory biomarker normalization with secukinumab: the randomized ObePso-S study","volume":"109","author":"Blauvelt","year":"2023","journal-title":"J. Dermatol. Sci."},{"issue":"7","key":"10.1016\/j.humimm.2024.111218_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111218_bb0110","unstructured":"Leek, J.T., Johnson, W.E., Parker, H.S., Fertig, E. J., Jaffe, A. E., Zhang, Y., Storey, J.D., & Torres, L. C. (2024). sva: Surrogate Variable Analysis. doi:10.18129\/B9.bioc.sva. Retrieved from https:\/\/bioconductor.org\/packages\/sva."},{"issue":"D1","key":"10.1016\/j.humimm.2024.111218_bb0115","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2024.111218_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"issue":"9","key":"10.1016\/j.humimm.2024.111218_bb0125","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jgg.2021.07.007","article-title":"EVenn: Easy to create repeatable and editable Venn diagrams and Venn networks online","volume":"48","author":"Chen","year":"2021","journal-title":"J. Gene. Geno."},{"issue":"14","key":"10.1016\/j.humimm.2024.111218_bb0130","article-title":"Disease and Treatment Characteristics in Geriatric Psoriasis: A Patient Survey Comparing Age Groups","volume":"100","author":"van Winden","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.humimm.2024.111218_bb0135","doi-asserted-by":"crossref","DOI":"10.1177\/11786469221078191","article-title":"Loss of Indoleamine-2,3-Dioxygenase-1 (IDO1) in Knockout Mice Does Not Affect the Development of Skin Lesions in the Imiquimod-Induced Mouse Model of Psoriasis","volume":"15","author":"Choudhary","year":"2022","journal-title":"Int. J. Tryptophan Res."},{"issue":"3","key":"10.1016\/j.humimm.2024.111218_bb0140","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00403-022-02379-3","article-title":"Expression of B lymphocyte-induced maturation protein 1 (Blimp-1) in keratinocyte and cytokine signalling drives human Th17 response in psoriasis","volume":"315","author":"da Costa","year":"2023","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.humimm.2024.111218_bb0145","doi-asserted-by":"crossref","DOI":"10.1080\/08916934.2023.2259137","article-title":"Integrated bioinformatics analysis identifies autophagy-associated genes as candidate biomarkers and reveals the immune infiltration landscape in psoriasis","volume":"57","author":"Bai","year":"2024","journal-title":"Autoimmunity"},{"issue":"21","key":"10.1016\/j.humimm.2024.111218_bb0150","doi-asserted-by":"crossref","first-page":"7224","DOI":"10.12998\/wjcc.v10.i21.7224","article-title":"Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study","volume":"10","author":"Wang","year":"2022","journal-title":"World J. Clinical Cases"},{"issue":"4","key":"10.1016\/j.humimm.2024.111218_bb0155","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/bjd.13993","article-title":"Frequency and characteristics of circulating CD4(+) CD28(null) T cells in patients with psoriasis","volume":"173","author":"Lima","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.humimm.2024.111218_bb0160","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3899\/jrheum.120257","article-title":"The inhibitor of costimulation of T cells: abatacept","volume":"89","author":"Iannone","year":"2012","journal-title":"J. Rheumatol. Suppl."},{"key":"10.1016\/j.humimm.2024.111218_bb0165","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.atherosclerosis.2021.09.024","article-title":"Targeting cytokines and immune checkpoints in atherosclerosis with monoclonal antibodies","volume":"335","author":"Lutgens","year":"2021","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.humimm.2024.111218_bb0170","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/art.42484","article-title":"Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101)","volume":"75","author":"Dillon","year":"2023","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.humimm.2024.111218_bb0175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/09546630600788885","article-title":"Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists","volume":"17","author":"Scheinfeld","year":"2006","journal-title":"J. Dermatol. Treat."},{"issue":"7455","key":"10.1016\/j.humimm.2024.111218_bb0180","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature12199","article-title":"BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis","volume":"498","author":"Roychoudhuri","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2024.111218_bb0185","doi-asserted-by":"crossref","unstructured":"Zwick D, Vo MT, Shim YJ, Reijonen H, Do JS. BACH2: The Future of Induced T-Regulatory Cell Therapies. Cells May 22 2024;13(11). doi:https:\/\/doi.org\/10.3390\/cells13110891","DOI":"10.3390\/cells13110891"},{"key":"10.1016\/j.humimm.2024.111218_bb0190","doi-asserted-by":"crossref","unstructured":"Imianowski CJ, Whiteside SK, Lozano T, et al. BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis. J. Exp. Med. Dec 5 2022;219(12)doi:https:\/\/doi.org\/10.1084\/jem.20211476","DOI":"10.1084\/jem.20211476"},{"issue":"4","key":"10.1016\/j.humimm.2024.111218_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250109","article-title":"Bach2 in CD4(+) T cells from SLE patients modulates B-cell differentiation and IgG production","volume":"53","author":"Long","year":"2023","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0200","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/2211-5463.13050","article-title":"Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in systemic lupus erythematosus","volume":"11","author":"Sheng","year":"2021","journal-title":"FEBS Open Bio."},{"issue":"2","key":"10.1016\/j.humimm.2024.111218_bb0205","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1172\/JCI82884","article-title":"The transcription factor BACH2 promotes tumor immunosuppression","volume":"126","author":"Roychoudhuri","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.humimm.2024.111218_bb0210","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.freeradbiomed.2021.04.003","article-title":"Bach2 regulates autophagy to modulate UVA-induced photoaging in skin fibroblasts","volume":"169","author":"Wang","year":"2021","journal-title":"Free Radic. Biol. Med."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924004816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885924004816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T16:12:05Z","timestamp":1740067925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885924004816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0198885924004816"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2024.111218","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a novel immunosenescence-related genes and integrative analyses in patients with psoriasis","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2024.111218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111218"}}