{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:54:31Z","timestamp":1793714071955,"version":"4.6.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100018730","name":"University of Sistan and Baluchestan","doi-asserted-by":"publisher","award":["59218942"],"award-info":[{"award-number":["59218942"]}],"id":[{"id":"10.13039\/501100018730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.humimm.2025.111250","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T18:32:07Z","timestamp":1738693927000},"page":"111250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interleukin 17 RA and RC gene polymorphisms and increased preeclampsia risk: Single and combined genetic analysis"],"prefix":"10.1016","volume":"86","author":[{"given":"Mohammad Amin","family":"Norouzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danial","family":"Jahantigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Forghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Ghazaey Zidanloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2025.111250_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogoh.2020.101975","article-title":"Preeclampsia: Pathophysiology and management","volume":"50","author":"Nirupama","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.humimm.2025.111250_b0010","article-title":"Risk factors and clinical features of pre-eclampsia in Iranian and Afghan mothers: A comparative study","author":"Kashanian","year":"2024","journal-title":"Int. J. Gynecol. Obstet."},{"key":"10.1016\/j.humimm.2025.111250_b0015","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.3390\/ijms25147569","article-title":"A Narrative Review on the Pathophysiology of Preeclampsia","volume":"25","author":"Torres-Torres","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.humimm.2025.111250_b0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41581-022-00670-0","article-title":"The role of immune cells and mediators in preeclampsia","volume":"19","author":"Deer","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.humimm.2025.111250_b0025","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13670","article-title":"New immune horizons in therapeutics and diagnostic approaches to Preeclampsia","volume":"89","author":"Mukherjee","year":"2023","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.humimm.2025.111250_b0030","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S1472-6483(10)60659-1","article-title":"Immunoregulation in normal pregnancy and pre-eclampsia: an overview","volume":"13","author":"Sargent","year":"2006","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.humimm.2025.111250_b0035","first-page":"295","article-title":"The presence, severity, and onset of preeclampsia is associated with maternal interleukin-23 level: A case-control study","volume":"21","author":"Forghani","year":"2023","journal-title":"Int J Reprod Biomed"},{"key":"10.1016\/j.humimm.2025.111250_b0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cyto.2017.08.012","article-title":"Association between maternal circulating IL-27 levels and preeclampsia","volume":"102","author":"Jahantigh","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.humimm.2025.111250_b0045","doi-asserted-by":"crossref","first-page":"256","DOI":"10.5114\/pdia.2014.40954","article-title":"Interleukin-17 in human inflammatory diseases","volume":"31","author":"Shabgah","year":"2014","journal-title":"Postep Dermatologii i Alergol"},{"key":"10.1016\/j.humimm.2025.111250_b0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejogrb.2020.03.039","article-title":"Circulating levels of IFN-\u03b3, IL-1, IL-17 and IL-22 in pre-eclampsia: A systematic review and meta-analysis","volume":"248","author":"Deng","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.humimm.2025.111250_b0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tjog.2020.03.013","article-title":"Expression imbalance of IL-17\/IL-35 in peripheral blood and placental tissue of pregnant women in preeclampsia","volume":"59","author":"Lu","year":"2020","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.humimm.2025.111250_b0060","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nri2586","article-title":"Structure and signalling in the IL-17 receptor family","volume":"9","author":"Gaffen","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2025.111250_b0065","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.3390\/ijms22136740","article-title":"From messengers to receptors in psoriasis: the role of IL-17RA in disease and treatment","volume":"22","author":"Vidal","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.humimm.2025.111250_b0070","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00011-021-01514-6","article-title":"Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis","volume":"70","author":"Villalpando-Vargas","year":"2021","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.humimm.2025.111250_b0075","doi-asserted-by":"crossref","first-page":"56","DOI":"10.32539\/bji.v10i2.191","article-title":"Single-Nucleotide Polymorphisms of Interleukin-17 and Susceptibility to Tuberculosis","volume":"10","author":"Nawawi","year":"2024","journal-title":"Biomed J Indones"},{"key":"10.1016\/j.humimm.2025.111250_b0080","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3547","article-title":"Serum IL-17A concentration and a IL17RA single nucleotide polymorphism contribute to the risk of autoimmune type 1 diabetes","volume":"38","author":"Li","year":"2022","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.humimm.2025.111250_b0085","article-title":"Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis","volume":"46","author":"da Silva","year":"2024","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.humimm.2025.111250_b0090","first-page":"139","article-title":"Association between polymorphisms of IL-23\/IL-17 pathway and clinical phenotypes of autoimmune thyroid diseases","volume":"19","author":"Cai","year":"2022","journal-title":"Iran. J. Immunol."},{"key":"10.1016\/j.humimm.2025.111250_b0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.humimm.2015.01.027","article-title":"Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort","volume":"76","author":"Coto","year":"2015","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2025.111250_b0100","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s00296-021-04996-z","article-title":"The role of IL-17 rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 SNPs and IL-17A serum levels in patients with lupus nephritis","volume":"41","author":"Hristova","year":"2021","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.humimm.2025.111250_b0105","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/HYPERTENSIONAHA.120.14781","article-title":"Subtypes of preeclampsia: recognition and determining clinical usefulness","volume":"77","author":"Roberts","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.humimm.2025.111250_b0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.arcmed.2021.07.004","article-title":"Polymorphisms at the IL17A and IL17RA Genes are Associated with Prognosis of Papillary Thyroid Carcinoma","volume":"53","author":"Bertol","year":"2022","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.humimm.2025.111250_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2474-13-181","article-title":"A single-nucleotide polymorphism rs708567 in the IL-17RC gene is associated with a susceptibility to and the curve severity of adolescent idiopathic scoliosis in a Chinese Han population: A case-control study","volume":"13","author":"Zhou","year":"2012","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.humimm.2025.111250_b0120","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1007\/s11033-020-05871-z","article-title":"IL-27 variants might be genetic risk factors for preeclampsia: based on genetic polymorphisms, haplotypes and in silico approach","volume":"47","author":"Jahantigh","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.humimm.2025.111250_b0125","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s10815-019-01479-w","article-title":"Interleukin-23 receptor (IL-23R) gene polymorphisms and haplotypes associated with the risk of preeclampsia: evidence from cross-sectional and in silico studies","volume":"36","author":"Jahantigh","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.humimm.2025.111250_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156182","article-title":"Corrigendum to \u201cInterleukin 12B rs3212227 and rs6887695 single nucleotide polymorphisms are associated with the susceptibility to preeclampsia: Genetic, haplotype and bioinformatics analysis\u201d [Cytokine 164 (2023) 156166] (Cytokine (2023) 164, (S1043466623","volume":"165","author":"Jahantigh","year":"2023","journal-title":"Cytokine"},{"key":"10.1016\/j.humimm.2025.111250_b0135","doi-asserted-by":"crossref","DOI":"10.1111\/exd.15152","article-title":"Genetic polymorphisms to identify patients with an optimal response to tildrakizumab in psoriasis patients from real-life clinical practice","volume":"33","author":"Butr\u00f3n-Bris","year":"2024","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.humimm.2025.111250_b0140","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/children11060657","article-title":"Impact of Interleukin-17 Receptor A Gene Variants on Asthma Susceptibility and Clinical Manifestations in Children and Adolescents","volume":"11","author":"Maher","year":"2024","journal-title":"Children"},{"key":"10.1016\/j.humimm.2025.111250_b0145","first-page":"117","article-title":"Investigating the association of IL-17A and IL-17F with susceptibility to pre-eclampsia in Iranian women","volume":"12","author":"Anvari","year":"2015","journal-title":"Iran. J. Immunol."},{"key":"10.1016\/j.humimm.2025.111250_b0150","doi-asserted-by":"crossref","DOI":"10.1186\/s12920-020-00840-8","article-title":"IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients","volume":"14","author":"Lang","year":"2021","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.humimm.2025.111250_b0155","article-title":"Role of IL-17 variants in preeclampsia in Chinese Han women","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2025.111250_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102429","article-title":"Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies","volume":"19","author":"Ruiz de Morales","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.humimm.2025.111250_b0165","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jri.2015.05.007","article-title":"Increased circulating interleukin-17 levels in preeclampsia","volume":"112","author":"Molvarec","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.humimm.2025.111250_b0170","doi-asserted-by":"crossref","first-page":"769","DOI":"10.7150\/ijms.71972","article-title":"IL-17: An important pathogenic factor in endometriosis","volume":"19","author":"Shi","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.humimm.2025.111250_b0175","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13503","article-title":"A review of key cytokines based on gene polymorphism in the pathogenesis of pre-eclampsia","volume":"87","author":"Guan","year":"2022","journal-title":"Am. J. Reprod. Immunol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925000217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925000217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T13:58:34Z","timestamp":1742219914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885925000217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0198885925000217"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111250","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin 17 RA and RC gene polymorphisms and increased preeclampsia risk: Single and combined genetic analysis","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111250","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111250"}}