{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:41:03Z","timestamp":1777938063633,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004412","name":"T\u00fcrkiye Bilimler Akademisi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016209","name":"Erciyes University Scientific Research Projects Coordination Unit","doi-asserted-by":"publisher","award":["TDK-2020\\u201310134"],"award-info":[{"award-number":["TDK-2020\\u201310134"]}],"id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.humimm.2025.111302","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T14:40:06Z","timestamp":1743864006000},"page":"111302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The number and frequency of mucosal-associated invariant T (MAIT), \u03b3\u03b4 T, and innate lymphoid cells (ILCs) altered in patients with type I Gaucher disease"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-1361","authenticated-orcid":false,"given":"Ramazan","family":"Uzen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-6744","authenticated-orcid":false,"given":"Fahri","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-0883","authenticated-orcid":false,"given":"Huseyin","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-7611","authenticated-orcid":false,"given":"Fatih","family":"Kardas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-5485","authenticated-orcid":false,"given":"Mustafa","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-9187","authenticated-orcid":false,"given":"Nurhan","family":"Cucer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-0686","authenticated-orcid":false,"given":"Ahmet","family":"Eken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-5813","authenticated-orcid":false,"given":"Hamiyet","family":"Donmez-Altuntas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2025.111302_b0005","doi-asserted-by":"crossref","unstructured":"S. Hassan, E. Sidransky, and N. Tayebi, \u201cThe role of epigenetics in lysosomal storage disorders: Uncharted territory,\u201d Molecular Genetics and Metabolism, vol. 122, no. 3. Academic Press Inc., pp. 10\u201318, Nov. 01, 2017. doi: 10.1016\/j.ymgme.2017.07.012.","DOI":"10.1016\/j.ymgme.2017.07.012"},{"issue":"12","key":"10.1016\/j.humimm.2025.111302_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom10121630","article-title":"Elevated Dkk1 mediates downregulation of the canonical wnt pathway and lysosomal loss in an iPSC model of neuronopathic Gaucher disease","volume":"10","author":"Srikanth","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.humimm.2025.111302_b0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/diseases5010010","article-title":"The Spectrum of Neurological Manifestations Associated with Gaucher Disease","volume":"5","author":"Roshan Lal","year":"2017","journal-title":"Diseases"},{"issue":"2","key":"10.1016\/j.humimm.2025.111302_b0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/imcb.12211","article-title":"MicroRNA miR-181a\/b-1 controls MAIT cell development","volume":"97","author":"Winter","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.humimm.2025.111302_b0025","unstructured":"W. E. Crusio, J. D. Lambris, and H. H. Radeke, \u201cAdvances in Experimental Medicine and Biology Volume 1224 Series Editors.\u201d [Online]. Available: http:\/\/www.springer.com\/series\/5584."},{"issue":"May","key":"10.1016\/j.humimm.2025.111302_b0030","first-page":"1","article-title":"MAIT Cell Activation and Functions","volume":"11","author":"Hinks","year":"2020","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.humimm.2025.111302_b0035","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-019-0444-8","article-title":"The biology and functional importance of MAIT cells","volume":"20","author":"Godfrey","year":"2019","journal-title":"Nat. Immunol."},{"issue":"19","key":"10.1016\/j.humimm.2025.111302_b0040","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1222678110","article-title":"The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins","volume":"110","author":"L\u00f3pez-Sagaseta","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"JUN","key":"10.1016\/j.humimm.2025.111302_b0045","first-page":"1","article-title":"Mucosal-associated invariant T cells in autoimmune diseases","volume":"9","author":"Chiba","year":"2018","journal-title":"Front. Immunol."},{"issue":"SEP","key":"10.1016\/j.humimm.2025.111302_b0050","article-title":"Mucosal-associated invariant T cells in multiple sclerosis: The jury is still out","volume":"6","author":"Treiner","year":"2015","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.humimm.2025.111302_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9030729","article-title":"Human Peripheral Blood Gamma Delta T Cells: Report on a Series of Healthy Caucasian Portuguese Adults and Comprehensive Review of the Literature","volume":"9","author":"Fonseca","year":"2020","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.humimm.2025.111302_b0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0248-8663(01)00529-X","article-title":"\u00c9tude r\u00e9trospective de 55 patients pr\u00e9sentant une lymphocytose T\u03b3\/\u03b4 dans le sang circulant","volume":"23","author":"Granel","year":"2002","journal-title":"Rev. Med. Interne"},{"issue":"12","key":"10.1016\/j.humimm.2025.111302_b0065","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41577-020-0345-y","article-title":"Thymic development of unconventional T cells: how NKT cells, MAIT cells and \u03b3\u03b4 T cells emerge","volume":"20","author":"Pellicci","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"Cll","key":"10.1016\/j.humimm.2025.111302_b0070","article-title":"Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity","volume":"2021","author":"De Ara\u00fajo","year":"2021","journal-title":"J Immunol. Res."},{"issue":"1","key":"10.1016\/j.humimm.2025.111302_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-024-06014-9","article-title":"Gamma-delta (\u03b3\u03b4) T Cells: Friend or Foe in Cancer Development","volume":"16","author":"Zhao","year":"2018","journal-title":"J. Transl. Med."},{"issue":"Spec 6\/1","key":"10.1016\/j.humimm.2025.111302_b0080","first-page":"564","article-title":"Innate lymphoid cells. New players in tissue homeostasis and inflammatory responses","volume":"79","author":"Zwirner","year":"2019","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.humimm.2025.111302_b0085","doi-asserted-by":"crossref","unstructured":"A. Eken, and H. Donmez-Altuntas, \u201cInnate Lymphoid Cells (Non \u2013 NK ILCs) Innate Lymphoid Cells (Non \u2013 NK ILCs),\u201d Isvoranu G. Ed. Lymph. Updat. \u2013 Cancer, Autoimmun. Infect. London InTech, pp. 129\u201348, 2017. doi: 10.5772\/intechopen.68893.","DOI":"10.5772\/intechopen.68893"},{"issue":"9","key":"10.1016\/j.humimm.2025.111302_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0108649","article-title":"Human CD117 (cKit)+ innate lymphoid cells have a discrete transcriptional profile at homeostasis and are expanded during filarial infection","volume":"9","author":"Boyd","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.humimm.2025.111302_b0095","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nri3855","article-title":"Transcriptional regulation of innate lymphoid cell fate","volume":"15","author":"Serafini","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2025.111302_b0100","doi-asserted-by":"crossref","unstructured":"C. Sotiropoulos et al., \u201cSevere impairment of regulatory T-cells and Th1-lymphocyte polarization in patients with gaucher disease,\u201d in JIMD Reports, vol. 18, Springer, 2015, pp. 107\u2013115. doi: 10.1007\/8904_2014_357","DOI":"10.1007\/8904_2014_357"},{"issue":"3","key":"10.1016\/j.humimm.2025.111302_b0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejmhg.2015.02.001","article-title":"Cytokines in Gaucher disease: Role in the pathogenesis of bone and pulmonary disease","volume":"16","author":"Tantawy","year":"2015","journal-title":"Egypt. J. Med. Hum. Genet."},{"issue":"7500","key":"10.1016\/j.humimm.2025.111302_b0110","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature13160","article-title":"T-cell activation by transitory neo-antigens derived from distinct microbial pathways","volume":"509","author":"Corbett","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2025.111302_b0115","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clinbiochem.2022.10.009","article-title":"Oxidative and chromosomal DNA damage in patients with type I Gaucher disease and carriers","volume":"111","author":"Uzen","year":"2023","journal-title":"Clin. Biochem."},{"issue":"4","key":"10.1016\/j.humimm.2025.111302_b0120","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/all.14081","article-title":"ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients","volume":"75","author":"Eken","year":"2020","journal-title":"Allergy Eur. J. Allergy Clin. Immunol."},{"issue":"20","key":"10.1016\/j.humimm.2025.111302_b0125","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1182\/blood-2011-10-386862","article-title":"Phenotype diversity in type 1 Gaucher disease: Discovering the genetic basis of Gaucher disease\/hematologic malignancy phenotype by individual genome analysis","volume":"119","author":"Lo","year":"2012","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.humimm.2025.111302_b0130","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1182\/blood-2014-09-600270","article-title":"Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation","volume":"125","author":"Nair","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2025.111302_b0135","doi-asserted-by":"crossref","unstructured":"A. Toubal, I. Nel, S. Lotersztajn, and A. Lehuen, \u201cMucosal-associated invariant T cells and disease,\u201d Nature Reviews Immunology, vol. 19, no. 10. Nature Publishing Group, pp. 643\u2013657, Oct. 01, 2019. doi: 10.1038\/s41577-019-0191-y.","DOI":"10.1038\/s41577-019-0191-y"},{"key":"10.1016\/j.humimm.2025.111302_b0140","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1016\/j.molmet.2019.06.025","article-title":"MAIT cells in metabolic diseases","volume":"27","author":"Bertrand","year":"2019","journal-title":"Mol. Metab.,"},{"key":"10.1016\/j.humimm.2025.111302_b0145","doi-asserted-by":"crossref","unstructured":"M. E. Kotas and R. M. Locksley, \u201cWhy Innate Lymphoid Cells?,\u201d Immunity, vol. 48, no. 6. NLM (Medline), pp. 1081\u20131090, Jun. 19, 2018. doi: 10.1016\/j.immuni.2018.06.002.","DOI":"10.1016\/j.immuni.2018.06.002"},{"issue":"MAY","key":"10.1016\/j.humimm.2025.111302_b0150","first-page":"1","article-title":"Innate lymphoid cells in mucosal immunity","volume":"10","author":"Panda","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2025.111302_b0155","first-page":"1","article-title":"Upregulation of Cytotoxic T \u2011 cells in pediatric patients with Gaucher disease","author":"Zahran","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.humimm.2025.111302_b0160","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12026-020-09129-5","article-title":"Downregulation of B regulatory cells and upregulation of T helper 1 cells in children with Gaucher disease undergoing enzyme replacement therapy","volume":"68","author":"Zahran","year":"2020","journal-title":"Immunol. Res."},{"key":"10.1016\/j.humimm.2025.111302_b0165","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bcmd.2016.10.016","article-title":"Could enzyme replacement therapy promote immune tolerance in Gaucher disease type 1?","volume":"68","author":"Matta","year":"2018","journal-title":"Blood Cells Mol. Dis."},{"issue":"6","key":"10.1016\/j.humimm.2025.111302_b0170","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1442-200X.2007.02502.x","article-title":"Roles of specific cytokines in bone remodeling and hematopoiesis in Gaucher disease","volume":"49","author":"Yoshino","year":"2007","journal-title":"Pediatr. Int."},{"issue":"3","key":"10.1016\/j.humimm.2025.111302_b0175","first-page":"197","article-title":"Immunological cells and functions in Gaucher disease","volume":"18","author":"Pandey","year":"2013","journal-title":"CritRevOncog."},{"key":"10.1016\/j.humimm.2025.111302_b0180","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-12-20","article-title":"Global gene expression profile progression in Gaucher disease mouse models","volume":"12","author":"Xu","year":"2011","journal-title":"BMC Genomics"},{"issue":"2","key":"10.1016\/j.humimm.2025.111302_b0185","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bcmd.2005.12.029","article-title":"Dendritic cells in patients with type I Gaucher disease are decreased in number but functionally normal","volume":"36","author":"Micheva","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"issue":"4","key":"10.1016\/j.humimm.2025.111302_b0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bcmd.2013.01.001","article-title":"Altered innate function of plasmacytoid dendritic cells restored by enzyme replacement therapy in Gaucher disease","volume":"50","author":"Braudeau","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"issue":"44","key":"10.1016\/j.humimm.2025.111302_b0195","doi-asserted-by":"crossref","first-page":"18054","DOI":"10.1073\/pnas.1207889109","article-title":"Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease","volume":"109","author":"Panicker","year":"2012","journal-title":"PNAS"},{"issue":"14","key":"10.1016\/j.humimm.2025.111302_b0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147618","article-title":"Innate lymphoid cells in intestinal homeostasis and inflammatory bowel disease","volume":"22","author":"Saez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"December","key":"10.1016\/j.humimm.2025.111302_b0205","article-title":"Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker","volume":"10","author":"Sheikh","year":"2019","journal-title":"Front. Immunol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925000734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925000734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:26:04Z","timestamp":1777695964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885925000734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0198885925000734"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111302","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The number and frequency of mucosal-associated invariant T (MAIT), \u03b3\u03b4 T, and innate lymphoid cells (ILCs) altered in patients with type I Gaucher disease","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111302","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111302"}}