{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:38:33Z","timestamp":1759451913444,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.humimm.2025.111333","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T13:55:22Z","timestamp":1748958922000},"page":"111333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic polymorphism contributes to efficacy and adverse reactions of tenofovir combination lamivudine-based highly active antiretroviral therapy in HIV-infected patients"],"prefix":"10.1016","volume":"86","author":[{"given":"Liu","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-1532","authenticated-orcid":false,"given":"Cuilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-8064","authenticated-orcid":false,"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2025.111333_b0005","unstructured":"HIV and AIDS, (n.d.). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hiv-aids (accessed August 16, 2024)."},{"key":"10.1016\/j.humimm.2025.111333_b0010","unstructured":"Global HIV & AIDS statistics \u2014 Fact sheet | UNAIDS, (n.d.). https:\/\/www.unaids.org\/en\/resources\/fact-sheet (accessed January 27, 2025)."},{"key":"10.1016\/j.humimm.2025.111333_b0015","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.46234\/ccdcw2021.249","article-title":"Research Progress in the Epidemiology of HIV\/AIDS in China","volume":"3","author":"He","year":"2021","journal-title":"China CDC Wkly."},{"key":"10.1016\/j.humimm.2025.111333_b0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.chom.2016.02.012","article-title":"Dissecting How CD4 T Cells Are Lost During HIV Infection","volume":"19","author":"Doitsh","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.humimm.2025.111333_b0025","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nrd.2016.173","article-title":"Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection","volume":"15","author":"Ferrari","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.humimm.2025.111333_b0030","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.jhep.2005.11.021","article-title":"Update on HAART in HIV","volume":"44","author":"Yeni","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.humimm.2025.111333_b0035","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3702740","article-title":"Tenofovir-Based Highly Active Antiretroviral Therapy Is Associated with Superior CD4 T Cells Repopulation Compared to Zidovudine-Based HAART in HIV 1 Infected Adults","author":"Badii","year":"2018","journal-title":"Int. J. Chronic Dis."},{"key":"10.1016\/j.humimm.2025.111333_b0040","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1053\/ajkd.2002.36924","article-title":"Fanconi syndrome and renal failure induced by tenofovir: a first case report","volume":"40","author":"Verhelst","year":"2002","journal-title":"Am. J. Kidney Dis. off. J. Natl. Kidney Found."},{"key":"10.1016\/j.humimm.2025.111333_b0045","first-page":"512","article-title":"Fanconi syndrome and chronic renal failure in a chronic hepatitis B monoinfected patient treated with tenofovir","volume":"107","author":"Magalh\u00e3es-Costa","year":"2015","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"10.1016\/j.humimm.2025.111333_b0050","article-title":"Tenofovir-Associated Kidney Dysfunction and Bone Fracture","volume":"16","author":"Athish","year":"2024","journal-title":"A Case Report and Literature Review, Cureus"},{"key":"10.1016\/j.humimm.2025.111333_b0055","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/QAD.0b013e3283262a64","article-title":"Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir","volume":"23","author":"Labarga","year":"2009","journal-title":"AIDS Lond. Engl."},{"key":"10.1016\/j.humimm.2025.111333_b0060","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/cid\/ciy382","article-title":"Ultrasensitive Human Immunodeficiency Virus Type 1 Viral Load as a Marker of Treatment Choice for Simplification Strategies","volume":"67","author":"Lambert-Niclot","year":"2018","journal-title":"Clin. Infect. Dis. off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.humimm.2025.111333_b0065","article-title":"The Role of Metabolic Dysfunction in T-Cell Exhaustion During Chronic Viral Infection","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2025.111333_b0070","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/QAD.0000000000000049","article-title":"A systematic review of definitions of extreme phenotypes of HIV control and progression","volume":"28","author":"Gurdasani","year":"2014","journal-title":"AIDS Lond. Engl."},{"key":"10.1016\/j.humimm.2025.111333_b0075","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5582\/bst.8.52","article-title":"Clinical epidemiology of HIV\/AIDS in China from 2004-2011","volume":"8","author":"Li","year":"2014","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.humimm.2025.111333_b0080","first-page":"82","article-title":"A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome, Pharmacogenet","volume":"25","author":"Dahlin","year":"2015","journal-title":"Genomics"},{"key":"10.1016\/j.humimm.2025.111333_b0085","first-page":"553","article-title":"Effects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean HIV-Infected Patients, Omics","volume":"19","author":"Mhandire","year":"2015","journal-title":"J. Integr. Biol."},{"key":"10.1016\/j.humimm.2025.111333_b0090","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(02)07873-X","article-title":"Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir","volume":"359","author":"Mallal","year":"2002","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.humimm.2025.111333_b0095","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1089\/aid.2011.0107","article-title":"HLA-dependent hypersensitivity reaction to nevirapine in Chinese Han HIV-infected patients","volume":"28","author":"Gao","year":"2012","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.humimm.2025.111333_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161562","article-title":"TREAT Asia HIV Observational Databases (TAHOD), Renal Dysfunction during Tenofovir Use in a Regional Cohort of HIV-Infected Individuals in the Asia-Pacific","volume":"11","author":"Tanuma","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2025.111333_b0105","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/QAD.0000000000000632","article-title":"Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort","volume":"29","author":"Zhang","year":"2015","journal-title":"AIDS Lond. Engl."},{"key":"10.1016\/j.humimm.2025.111333_b0110","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9172607","article-title":"Reduced Kidney Function in Tenofovir Disoproxil Fumarate Based Regimen and Associated Factors: A Hospital Based Prospective Observational Study in Ethiopian Patients","volume":"2019","author":"Yazie","year":"2019","journal-title":"Int. J. Nephrol."},{"key":"10.1016\/j.humimm.2025.111333_b0115","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/labinvest.2009.14","article-title":"Tenofovir renal toxicity targets mitochondria of renal proximal tubules","volume":"89","author":"Kohler","year":"2009","journal-title":"Lab. Investig. J. Tech. Methods Pathol."},{"key":"10.1016\/j.humimm.2025.111333_b0120","article-title":"Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir Toxicity","volume":"4","author":"Pearson","year":"2023","journal-title":"Funct. Oxf. Engl."},{"issue":"47","key":"10.1016\/j.humimm.2025.111333_b0125","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/QAI.0b013e31815e7478","article-title":"Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients","volume":"1999","author":"Kiser","year":"2008","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.humimm.2025.111333_b0130","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1086\/508546","article-title":"Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy","volume":"194","author":"Izzedine","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.humimm.2025.111333_b0135","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/cid\/cis772","article-title":"Single nucleotide polymorphisms in ABCC2 associate with tenofovir-induced kidney tubular dysfunction in Japanese patients with HIV-1 infection: a pharmacogenetic study","volume":"55","author":"Nishijima","year":"2012","journal-title":"Clin. Infect. Dis. off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.humimm.2025.111333_b0140","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1097\/INF.0b013e31829e6c9c","article-title":"Tenofovir-induced renal tubular dysfunction in vertically HIV-infected patients associated with polymorphisms in ABCC2, ABCC4 and ABCC10 genes","volume":"32","author":"Giacomet","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.humimm.2025.111333_b0145","unstructured":"INSIGHT-ESPRIT Study Group S.I.L.C.A.A.T. Scientific Committee D. Abrams Y. L\u00e9vy M.H. Losso A. Babiker G. Collins D.A. Cooper J. Darbyshire S. Emery L. Fox F. Gordin H.C. Lane J.D. Lundgren R. Mitsuyasu J.D. Neaton A. Phillips J.P. Routy G. Tambussi D. Wentworth Interleukin-2 therapy in patients with HIV infection N. Engl. J. Med. 361 2009 1548 1559 10.1056\/NEJMoa0903175."},{"key":"10.1016\/j.humimm.2025.111333_b0150","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nri2023","article-title":"Interleukin-7 receptor expression: intelligent design","volume":"7","author":"Mazzucchelli","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2025.111333_b0155","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/QAD.0b013e3283519214","article-title":"ILIADE Study Group, Effect of intermittent interleukin-2 therapy on CD4+ T-cell counts following antiretroviral cessation in patients with HIV","volume":"26","author":"L\u00e9vy","year":"2012","journal-title":"AIDS Lond. Engl."},{"key":"10.1016\/j.humimm.2025.111333_b0160","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1182\/blood-2015-05-645077","article-title":"Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia","volume":"127","author":"Sheikh","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2025.111333_b0165","doi-asserted-by":"crossref","first-page":"42036","DOI":"10.1038\/srep42036","article-title":"Gene variation in IL-7 receptor (IL-7R)\u03b1 affects IL-7R response in CD4+ T cells in HIV-infected individuals","volume":"7","author":"Hartling","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2025.111333_b0170","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1097\/QAD.0000000000000354","article-title":"Polymorphism in interleukin-7 receptor \u03b1 gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy","volume":"28","author":"Hartling","year":"2014","journal-title":"AIDS Lond. Engl."},{"key":"10.1016\/j.humimm.2025.111333_b0175","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.rce.2023.12.003","article-title":"Polymorphisms of CCR5, IL-6, IFN-\u03b3 and IL-10 genes in Cuban HIV\/AIDS patients","volume":"224","author":"Hern\u00e1ndez Requejo","year":"2024","journal-title":"Rev. Clin. Esp."},{"key":"10.1016\/j.humimm.2025.111333_b0180","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1086\/423209","article-title":"Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1","volume":"190","author":"Liu","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.humimm.2025.111333_b0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000369016","article-title":"Genotyping of CCR5 gene, CCR2b and SDF1 variants related to HIV-1 infection in Gabonese subjects","volume":"58","author":"Mombo","year":"2015","journal-title":"Intervirology"},{"key":"10.1016\/j.humimm.2025.111333_b0190","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.humimm.2025.111333_b0195","doi-asserted-by":"crossref","first-page":"16483","DOI":"10.3390\/ijms160716483","article-title":"Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population","volume":"16","author":"Wang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.humimm.2025.111333_b0200","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/cells7120234","article-title":"Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast Carcinogenesis","volume":"7","author":"Das","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.humimm.2025.111333_b0205","first-page":"2149","article-title":"Nuclear Respiratory Factor-1 (NRF-1) Gene Expression in Chronic Kidney Disease Patients Undergoing Hemodialysis and Mitochondrial Oxidative Dysregulation","volume":"62","author":"Hashad","year":"2016","journal-title":"Clin.Lab.2"},{"key":"10.1016\/j.humimm.2025.111333_b0210","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1084\/jem.20180783","article-title":"N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1","volume":"215","author":"Yang","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.humimm.2025.111333_b0215","doi-asserted-by":"crossref","unstructured":"L. Yu B. Gong W. Duan C. Fan J. Zhang Z. Li X. Xue Y. Xu D. Meng B. Li M. Zhang null Bin Zhang, Z. Jin, S. Yu, Y. Yang, H. Wang, Melatonin ameliorates myocardial ischemia\/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1\u03b1-SIRT3 signaling Sci. Rep. 7 2017 41337 10.1038\/srep41337.","DOI":"10.1038\/srep41337"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925001041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925001041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:16:03Z","timestamp":1759400163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885925001041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0198885925001041"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111333","relation":{},"ISSN":["0198-8859"],"issn-type":[{"type":"print","value":"0198-8859"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic polymorphism contributes to efficacy and adverse reactions of tenofovir combination lamivudine-based highly active antiretroviral therapy in HIV-infected patients","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111333"}}