{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:47:21Z","timestamp":1791859641771,"version":"4.3.4"},"reference-count":98,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.humimm.2025.111340","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T12:36:03Z","timestamp":1752582963000},"page":"111340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nine neutrophil enzyme pathways can initiate hyperinflammatory or autoimmune diseases"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-9835","authenticated-orcid":false,"given":"Kevin","family":"Roe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0005","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.3390\/microorganisms11051262","article-title":"Markers of Epstein-Barr virus infection in patients with multiple sclerosis","volume":"11","author":"Debuysschere","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.humimm.2025.111340_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1307589","article-title":"Epstein-Barr virus infection as potential indicator of the occurrence and clinical presentation of systemic lupus erythematosus","volume":"14","author":"Banko","year":"2023","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.humimm.2025.111340_b0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.arcmed.2021.03.012","article-title":"Emerging roles of coronavirus in autoimmune diseases","volume":"52","author":"Zhou","year":"2021","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.humimm.2025.111340_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.751341","article-title":"Changes in MDA5 and TLR3 sensing of the same diabetogenic virus result in different autoimmune disease outcomes","volume":"12","author":"Lincez","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2025.111340_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.751337","article-title":"Virus infection is an instigator of intestinal dysbiosis leading to type 1 diabetes","volume":"12","author":"Morse","year":"2021","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.humimm.2025.111340_b0030","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/1753-0407.13187","article-title":"New-onset diabetes in \u201clong COVID\u201d","volume":"13","author":"Sathish","year":"2021","journal-title":"J. Diabetes"},{"key":"10.1016\/j.humimm.2025.111340_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102078","article-title":"Calculating the fraction of Kawasaki disease potentially attributable to seasonal pathogens: a time series analysis","volume":"61","author":"Valtuille","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.humimm.2025.111340_b0040","article-title":"Comparable bidirectional neutrophil immune dysregulation between Kawasaki disease and severe COVID-19","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.humimm.2025.111340_b0045","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41390-019-0710-3","article-title":"Enhanced formation of neutrophil extracellular traps in Kawasaki disease","volume":"87","author":"Yoshida","year":"2020","journal-title":"Pediatr. Res."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0050","first-page":"327","article-title":"Neutrophil extracellular traps formation and citrullinated histones 3 levels in patients with Kawasaki disease","volume":"20","author":"Hu","year":"2023","journal-title":"Iran. J. Immunol."},{"issue":"21","key":"10.1016\/j.humimm.2025.111340_b0055","doi-asserted-by":"crossref","first-page":"15805","DOI":"10.3390\/ijms242115805","article-title":"Role of neutrophil extracellular traps in health and disease pathophysiology: recent insights and advances","volume":"24","author":"Islam","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.humimm.2025.111340_b0060","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1530\/JME-20-0128","article-title":"NETosis contributes to the pathogenesis of diabetes and its complications","volume":"65","author":"Njeim","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.humimm.2025.111340_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.649693","article-title":"Neutrophils in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus: same foe different M.O","volume":"12","author":"Fresneda Alarcon","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0070","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.47363","article-title":"Temporal correlation between Kawasaki disease and infectious diseases in South Korea","volume":"5","author":"Kang","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"9","key":"10.1016\/j.humimm.2025.111340_b0075","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S2352-4642(20)30175-9","article-title":"Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis","volume":"4","author":"Ouldali","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"issue":"1","key":"10.1016\/j.humimm.2025.111340_b0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s42399-020-00690-6","article-title":"Emerging evidence on multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection: a systematic review with meta-analysis","volume":"3","author":"Sood","year":"2021","journal-title":"SN Compr. Clin. Med."},{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0085","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/20009666.2020.1787811","article-title":"Macrophage activation syndrome in a patient with systemic lupus erythematosus (SLE) and dual viremia","volume":"10","author":"Awasthi","year":"2020","journal-title":"J. Community Hosp. Intern. Med. Perspect."},{"issue":"8","key":"10.1016\/j.humimm.2025.111340_b0090","article-title":"COVID-19 and hyperinflammatory syndrome in children: Kawasaki disease with macrophage activation syndrome in disguise?","volume":"12","author":"Loomba","year":"2020","journal-title":"Cureus."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0095","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/art.43019","article-title":"Exploring the role of neutrophil extracellular traps in systemic lupus erythematosus: a clinical case study and comprehensive review","volume":"77","author":"Kaplan","year":"2025","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.humimm.2025.111340_b0100","doi-asserted-by":"crossref","first-page":"103399","DOI":"10.1016\/j.jaut.2025.103399","article-title":"Aberrant expansion of CD177+ neutrophils promotes endothelial dysfunction in systemic lupus erythematosus via neutrophil extracellular traps","volume":"152","author":"Xu","year":"2025","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.humimm.2025.111340_b0105","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.3390\/ijms26062789","article-title":"The crosstalk between NETs and the complement cascade: an overview in nephrological autoimmune disease","volume":"26","author":"Kajana","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.humimm.2025.111340_b0110","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41423-020-0402-2","article-title":"Functional exhaustion of antiviral lymphocytes in COVID-19 patients","volume":"17","author":"Zheng","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0115","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s13577-023-00862-1","article-title":"Hyperinflammatory disease and vasculitis-associated autoimmune disease pathogenesis by novel virulent pathogens inducing lymphocyte exhaustion and\/or suppression","volume":"36","author":"Roe","year":"2023","journal-title":"Hum. Cell"},{"issue":"21","key":"10.1016\/j.humimm.2025.111340_b0120","doi-asserted-by":"crossref","first-page":"11378","DOI":"10.3390\/ijms222111378","article-title":"Postoperative natural killer cell dysfunction: the prime suspect in the case of metastasis following curative cancer surgery","volume":"22","author":"Market","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113879","article-title":"LAG-3- and CXCR5-expressing CD4 T cells display progenitor-like properties during chronic visceral leishmaniasis","volume":"43","author":"Swaminathan","year":"2024","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.humimm.2025.111340_b0130","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/jcpt.13560","article-title":"Explanations for 10 of the most puzzling aspects of multisystem inflammatory syndrome and other Kawasaki-like diseases","volume":"47","author":"Roe","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"issue":"8","key":"10.1016\/j.humimm.2025.111340_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110399","article-title":"Follicular Tcells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice","volume":"38","author":"Cavazzoni","year":"2022","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.humimm.2025.111340_b0140","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.immuni.2020.11.006","article-title":"Germinal center and extrafollicular B cell responses in vaccination, immunity, and autoimmunity","volume":"53","author":"Elsner","year":"2020","journal-title":"Immunity"},{"issue":"14","key":"10.1016\/j.humimm.2025.111340_b0145","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1111\/febs.15803","article-title":"Roles of neutrophil granule proteins in orchestrating inflammation and immunity","volume":"289","author":"Othman","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.humimm.2025.111340_b0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2025.111340_b0155","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ni.2921","article-title":"Neutrophils at work","volume":"15","author":"Nauseef","year":"2014","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.humimm.2025.111340_b0160","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrneph.2016.71","article-title":"The role of neutrophils and NETosis in autoimmune and renal diseases","volume":"12","author":"Gupta","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"8","key":"10.1016\/j.humimm.2025.111340_b0165","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/cells8080790","article-title":"NK cell induced T cell anergy depends on GRAIL expression","volume":"8","author":"Galazka","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.humimm.2025.111340_b0170","doi-asserted-by":"crossref","first-page":"E2973","DOI":"10.1073\/pnas.1524924113","article-title":"Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation","volume":"113","author":"Gross","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2025.111340_b0175","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41423-020-0412-0","article-title":"Neutrophil chemoattractant receptors in health and disease: double-edged swords","volume":"17","author":"Metzemaekers","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0180","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000955","article-title":"Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression","volume":"4","author":"Rendeiro","year":"2020","journal-title":"Life Sci. Alliance"},{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0185","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/j.jinf.2020.03.001","article-title":"Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation","volume":"80","author":"Ye","year":"2020","journal-title":"J. Infect."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0190","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jaci.2021.10.015","article-title":"Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome","volume":"149","author":"Huang","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0195","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jaci.2022.09.006","article-title":"Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohort","volume":"150","author":"Rey-Jurado","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.humimm.2025.111340_b0200","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4049\/jimmunol.1400478","article-title":"Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via Fc\u03b3RIIIB and Mac-1","volume":"193","author":"Behnen","year":"2014","journal-title":"J. Immunol."},{"issue":"16","key":"10.1016\/j.humimm.2025.111340_b0205","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1182\/blood-2013-07-516484","article-title":"Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation","volume":"123","author":"Rossaint","year":"2014","journal-title":"Blood"},{"issue":"378","key":"10.1016\/j.humimm.2025.111340_b0210","article-title":"Neutrophil attachment via Mac-1 (\u03b1M\u03b22; CD11b\/CD18; CR3) integrins induces PAD4 deimination of profilin and histone H3","volume":"2023","author":"Neeli","year":"1890","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0215","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.4049\/jimmunol.180.3.1895","article-title":"Histone deimination as a response to inflammatory stimuli in neutrophils","volume":"180","author":"Neeli","year":"2008","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0220","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.devcel.2018.01.019","article-title":"Neutrophil extracellular traps: the biology of chromatin externalization","volume":"44","author":"Sollberger","year":"2018","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0225","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.3390\/ijms24031841","article-title":"Superoxide anion chemistry-its role at the core of the innate immunity","volume":"24","author":"Andr\u00e9s","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.humimm.2025.111340_b0230","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3390\/biom14101307","article-title":"How do ROS induce NETosis? Oxidative DNA damage, DNA repair, and chromatin decondensation","volume":"14","author":"Azzouz","year":"2024","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.humimm.2025.111340_b0235","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1182\/blood-2013-09-526707","article-title":"Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis","volume":"123","author":"Douda","year":"2014","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0240","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/cr.2010.150","article-title":"Neutrophil extracellular trap cell death requires both autophagy and superoxide generation","volume":"21","author":"Remijsen","year":"2011","journal-title":"Cell Res"},{"issue":"4","key":"10.1016\/j.humimm.2025.111340_b0245","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/biom14040416","article-title":"Composition and function of neutrophil extracellular traps","volume":"14","author":"Wang","year":"2024","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.humimm.2025.111340_b0250","doi-asserted-by":"crossref","first-page":"41749","DOI":"10.1038\/srep41749","article-title":"Transcriptional firing helps to drive NETosis","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.humimm.2025.111340_b0255","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1073\/pnas.1414055112","article-title":"SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx","volume":"112","author":"Douda","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0260","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/annrheumdis-2013-203844","article-title":"Citrullination of autoantigens implicates NETosis in the induction of autoimmunity","volume":"73","author":"Dwivedi","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"16","key":"10.1016\/j.humimm.2025.111340_b0265","first-page":"2784","article-title":"NETosis: how vital is it?","volume":"122","author":"Yipp","year":"2013","journal-title":"Blood J. Am. Soc. Hematol."},{"issue":"15","key":"10.1016\/j.humimm.2025.111340_b0270","first-page":"3118","article-title":"Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 \u03b1","volume":"120","author":"McInturff","year":"2012","journal-title":"Blood J. Am. Soc. Hematol."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0275","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J. Cell Biol."},{"issue":"21","key":"10.1016\/j.humimm.2025.111340_b0280","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1080\/15384101.2019.1662678","article-title":"Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-\u03baB signaling in macrophages","volume":"18","author":"An","year":"2019","journal-title":"Cell Cycle"},{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0285","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1128\/IAI.00050-12","article-title":"Afa\/Dr diffusely adhering Escherichia coli strain C1845 induces neutrophil extracellular traps that kill bacteria and damage human enterocyte-like cells","volume":"80","author":"Marin-Esteban","year":"2012","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.humimm.2025.111340_b0290","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.humimm.2025.111340_b0295","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7592851","article-title":"An overview of the intrinsic role of citrullination in autoimmune disorders","volume":"2019","author":"Alghamdi","year":"2019","journal-title":"J. Immunol. Res."},{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0300","first-page":"616","article-title":"Protein arginine deiminase 4 (PAD4): current understanding and future therapeutic potential","volume":"12","author":"Jones","year":"2009","journal-title":"Curr. Opin. Drug Discov. Devel."},{"issue":"1","key":"10.1016\/j.humimm.2025.111340_b0305","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00726-008-0210-y","article-title":"Arginine metabolism and nutrition in growth, health and disease","volume":"37","author":"Wu","year":"2009","journal-title":"Amino Acids"},{"issue":"6","key":"10.1016\/j.humimm.2025.111340_b0310","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.1959","article-title":"Netting neutrophils in autoimmune small-vessel vasculitis","volume":"15","author":"Kessenbrock","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.humimm.2025.111340_b0315","doi-asserted-by":"crossref","first-page":"73ra20","DOI":"10.1126\/scitranslmed.3001201","article-title":"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.humimm.2025.111340_b0320","doi-asserted-by":"crossref","first-page":"73ra19","DOI":"10.1126\/scitranslmed.3001180","article-title":"Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus","volume":"3","author":"Lande","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.humimm.2025.111340_b0325","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/all.12111","article-title":"Extracellular DNA traps in allergic, infectious, and autoimmune diseases","volume":"68","author":"Simon","year":"2013","journal-title":"Allergy"},{"issue":"21","key":"10.1016\/j.humimm.2025.111340_b0330","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.1073\/pnas.0909927107","article-title":"Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis","volume":"107","author":"Hakkim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0335","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3899\/jrheum.181232","article-title":"Neutrophil extracellular traps profiles in patients with incident systemic lupus erythematosus and lupus nephritis","volume":"47","author":"Bruschi","year":"2020","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.humimm.2025.111340_b0340","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.3389\/fimmu.2018.03033","article-title":"Differential ACPA binding to nuclear antigens reveals a PAD-independent pathway and a distinct subset of acetylation cross-reactive autoantibodies in rheumatoid arthritis","volume":"9","author":"Lloyd","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2025.111340_b0345","article-title":"The emerging role of neutrophil extracellular traps in the progression of rheumatoid arthritis","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.humimm.2025.111340_b0350","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.3390\/ijms221810106","article-title":"Efficient neutrophil activation requires two simultaneous activating stimuli","volume":"22","author":"Mol","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0355","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/annrheumdis-2018-213523","article-title":"Humanised effector-null Fc\u03b3RIIA antibody inhibits immune complex-mediated proinflammatory responses","volume":"78","author":"Chen","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.humimm.2025.111340_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109142","article-title":"Inhibitory affinity modulation of Fc\u03b3RIIA ligand binding by glycosphingolipids by inside-out signaling","volume":"35","author":"Okubo","year":"2021","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.humimm.2025.111340_b0365","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41431-021-00838-5","article-title":"Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease","volume":"29","author":"Hoggart","year":"2021","journal-title":"Eur. J. Hum. Genet."},{"issue":"10","key":"10.1016\/j.humimm.2025.111340_b0370","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/gtmb.2018.0042","article-title":"A case-control study on association of ulcerative colitis with FCGR2A gene polymorphisms in Chinese patients","volume":"22","author":"Xia","year":"2018","journal-title":"Genet. Test. Mol. Biomarkers"},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0375","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s10753-015-0275-1","article-title":"Fc gamma receptor IIA (CD32A) R131 polymorphism as a marker of genetic susceptibility to sepsis","volume":"39","author":"Beppler","year":"2016","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.humimm.2025.111340_b0380","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.12350","article-title":"Mouse and human FcR effector functions","volume":"268","author":"Bruhns","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.humimm.2025.111340_b0385","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3389\/fimmu.2019.00811","article-title":"Understanding Fc receptor involvement in inflammatory diseases: from mechanisms to new therapeutic tools","volume":"10","author":"Ben Mkaddem","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2025.111340_b0390","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3389\/fimmu.2019.01958","article-title":"Expression, role, and regulation of neutrophil Fc\u03b3 receptors","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.humimm.2025.111340_b0395","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1038\/s41467-018-07506-1","article-title":"Cis interaction between sialylated Fc\u03b3RIIA and the \u03b1I-domain of Mac-1 limits antibody-mediated neutrophil recruitment","volume":"9","author":"Saggu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.humimm.2025.111340_b0400","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.657393","article-title":"The antibody receptor fc gamma receptor IIIb induces calcium entry via transient receptor potential melastatin 2 in human neutrophils","volume":"12","author":"Alem\u00e1n","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.humimm.2025.111340_b0405","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/s41467-020-15088-0","article-title":"Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis","volume":"11","author":"Mutoh","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.humimm.2025.111340_b0410","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41419-021-03528-8","article-title":"Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions","volume":"12","author":"Karmakar","year":"2021","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0415","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4049\/jimmunol.1800300","article-title":"Lupus-associated immune complexes activate human neutrophils in an Fc\u03b3RIIA-dependent but TLR-independent response","volume":"202","author":"Bonegio","year":"2019","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.humimm.2025.111340_b0420","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/MOH.0000000000000423","article-title":"Hemolysis and immune regulation","volume":"25","author":"Zhong","year":"2018","journal-title":"Curr. Opin. Hematol."},{"issue":"Suppl 7","key":"10.1016\/j.humimm.2025.111340_b0425","doi-asserted-by":"crossref","first-page":"S529","DOI":"10.1093\/cid\/ciz825","article-title":"The role of iron and siderophores in infection, and the development of siderophore antibiotics","volume":"69","author":"Page","year":"2019","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.humimm.2025.111340_b0430","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1021\/acs.chemrev.0c01005","article-title":"Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics","volume":"121","author":"Klebba","year":"2021","journal-title":"Chem. Rev."},{"issue":"24","key":"10.1016\/j.humimm.2025.111340_b0435","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2013-10-529982","article-title":"Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease","volume":"123","author":"Chen","year":"2014","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.humimm.2025.111340_b0440","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1111\/trf.12700","article-title":"Heme-related molecules induce rapid production of neutrophil extracellular traps","volume":"54","author":"Kono","year":"2014","journal-title":"Transfusion"},{"key":"10.1016\/j.humimm.2025.111340_b0445","first-page":"147","article-title":"Quantitative analysis of hemin-induced neutrophil extracellular trap formation and effects of hydrogen peroxide on this phenomenon","volume":"11","author":"Ohbuchi","year":"2017","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.humimm.2025.111340_b0450","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fimmu.2018.00038","article-title":"Bioactive lipids and chronic inflammation: managing the fire within","volume":"9","author":"Chiurchi\u00f9","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2025.111340_b0455","doi-asserted-by":"crossref","unstructured":"M.F. Neurath, Resolution of inflammation: from basic concepts to clinical application, Seminars in Immunopathology Berlin\/Heidelberg, 41, Springer Berlin Heidelberg, 2019, pp. 627\u2013631, https:\/\/doi.org\/10.1007\/s00281-019-00771-2.","DOI":"10.1007\/s00281-019-00771-2"},{"issue":"4","key":"10.1016\/j.humimm.2025.111340_b0460","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0465","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/imcb.12206","article-title":"Efferocytosis: molecular mechanisms and pathophysiological perspectives","volume":"97","author":"Gheibi Hayat","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.humimm.2025.111340_b0470","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/549691","article-title":"PPAR\u03b3 and the innate immune system mediate the resolution of inflammation","author":"Croasdell","year":"2015","journal-title":"PPAR Res."},{"issue":"14","key":"10.1016\/j.humimm.2025.111340_b0475","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.3390\/diagnostics13142338","article-title":"Intravenous immunoglobulin in Kawasaki disease-evolution and pathogenic mechanisms","volume":"13","author":"Nadig","year":"2023","journal-title":"Diagnostics (Basel)."},{"issue":"5","key":"10.1016\/j.humimm.2025.111340_b0480","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/SLA.0000000000006196","article-title":"NETosis in surgery: pathophysiology, prevention, and treatment","volume":"279","author":"James","year":"2024","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.humimm.2025.111340_b0485","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1084\/jem.20160530","article-title":"Peptidylarginine deiminase 4 promotes age-related organ fibrosis","volume":"214","author":"Martinod","year":"2017","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.humimm.2025.111340_b0490","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/SHK.0000000000001476","article-title":"Removal of circulating neutrophil extracellular trap components with an immobilized polymyxin B filter: a preliminary study","volume":"54","author":"Gocho","year":"2020","journal-title":"Shock"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925001119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925001119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:17:45Z","timestamp":1759400265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885925001119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":98,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0198885925001119"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111340","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nine neutrophil enzyme pathways can initiate hyperinflammatory or autoimmune diseases","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111340"}}