{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:15:21Z","timestamp":1782836121663,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["401235\/2020-3"],"award-info":[{"award-number":["401235\/2020-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["153643\/2024-2 \\u2013 CNPQ 58\/2022"],"award-info":[{"award-number":["153643\/2024-2 \\u2013 CNPQ 58\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["153000\/2022-8 \\u2013 CNPQ 25\/2021"],"award-info":[{"award-number":["153000\/2022-8 \\u2013 CNPQ 25\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005288","name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa","doi-asserted-by":"publisher","award":["006\/2020"],"award-info":[{"award-number":["006\/2020"]}],"id":[{"id":"10.13039\/501100005288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005288","name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa","doi-asserted-by":"publisher","award":["005\/2020"],"award-info":[{"award-number":["005\/2020"]}],"id":[{"id":"10.13039\/501100005288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003760","name":"Secretaria de Estado de Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["09\/2021"],"award-info":[{"award-number":["09\/2021"]}],"id":[{"id":"10.13039\/501100003760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.humimm.2025.111341","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:48:12Z","timestamp":1751582892000},"page":"111341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gene expression profile of immune response markers associated with long COVID and its clinical aspects in a cohort from northern Brazil"],"prefix":"10.1016","volume":"86","author":[{"given":"Leonn Mendes","family":"Soares Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izailton","family":"de Souza e Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandrey Roberto","family":"dos Santos Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Ferreira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via P\u00f3voa","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Matheus","family":"Lima de Sarges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Henrique","family":"Damasceno Cantanhede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mioni Thieli Figueiredo Magalh\u00e3es","family":"de Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Luciana Soares","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"de Meira Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Nazar\u00e9 do Socorro","family":"de Almeida Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola Brasil","family":"Barbosa Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosilene","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle Maria","family":"Rachid Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia","family":"do Socorro Souza Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"de Oliveira Lameira Ver\u00edssimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara","family":"da Silva Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Freitas","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Pinheiro","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Abreu","family":"Lima Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iran Barros","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izaura Maria","family":"Vieira Cayres-Vallinoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Brasil-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juarez Ant\u00f4nio","family":"Sim\u00f5es Quaresma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Nazare","family":"Monteiro Rangel da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alice","family":"Freitas Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Jos\u00e9 Melo","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz F\u00e1bio","family":"Magno Falc\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Ros\u00e1rio Vallinoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.humimm.2025.111341_b0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"40","key":"10.1016\/j.humimm.2025.111341_b0010","article-title":"Long COVID challenges in Brazil: an unfinished agenda for the Brazilian Unified National Health System","volume":"19","author":"Ramos","year":"2024","journal-title":"Cad. Saude Publica"},{"issue":"10","key":"10.1016\/j.humimm.2025.111341_b0015","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/23744235.2021.1924397","article-title":"Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments","volume":"53","author":"Yong","year":"2021","journal-title":"Infect. Dis."},{"issue":"20","key":"10.1016\/j.humimm.2025.111341_b0020","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1016\/j.cell.2024.07.054","article-title":"Mechanisms of long COVID and the path toward therapeutics","volume":"187","author":"Peluso","year":"2024","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmii.2022.10.003","article-title":"Long COVID: an inevitable sequela of SARS-CoV-2 infection","volume":"56","author":"Lai","year":"2023","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"370","key":"10.1016\/j.humimm.2025.111341_b0030","article-title":"Management of post-acute covid-19 in primary care","volume":"11","author":"Greenhalgh","year":"2020","journal-title":"BMJ"},{"issue":"712","key":"10.1016\/j.humimm.2025.111341_b0035","doi-asserted-by":"crossref","first-page":"e815","DOI":"10.3399\/BJGP.2021.0265","article-title":"Recommendations for the recognition, diagnosis, and management of long COVID: a Delphi study","volume":"71","author":"Nurek","year":"2021","journal-title":"Br. J. Gen. Pract."},{"key":"10.1016\/j.humimm.2025.111341_b0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbi.2023.03.022","article-title":"COVID-19 vaccination for the prevention and treatment of long COVID: a systematic review and meta-analysis","volume":"111","author":"Ceban","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.humimm.2025.111341_b0045","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S1473-3099(23)00287-6","article-title":"Prevention of long COVID: progress and challenges","volume":"23","author":"Al-Aly","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.humimm.2025.111341_b0050","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00726-021-02991-z","article-title":"Human cell receptors: potential drug targets to combat COVID-19","volume":"53","author":"Raghav","year":"2021","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphs.2023.02.004","article-title":"Potential treatments of COVID-19: drug repurposing and therapeutic interventions","volume":"152","author":"Raghav","year":"2023","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.humimm.2025.111341_b0060","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41598-022-20773-9","article-title":"Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations","volume":"13","author":"Raghav","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2025.111341_b0065","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1515\/cclm-2021-1021","article-title":"The pathogenesis, epidemiology and biomarkers of susceptibility of pulmonary fibrosis in COVID-19 survivors","volume":"60","author":"Vianello","year":"2022","journal-title":"Clin. Chem. Lab. Med."},{"issue":"6","key":"10.1016\/j.humimm.2025.111341_b0070","article-title":"The IL-1\u03b2, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19","volume":"3","author":"Schulthei\u00df","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.humimm.2025.111341_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1174020","article-title":"Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers","volume":"14","author":"Damiano","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2025.111341_b0080","article-title":"Heart rate Variability and circulating inflammatory Markers in midlife","volume":"15","author":"Alen","year":"2021","journal-title":"Brain Behav Immun Health."},{"key":"10.1016\/j.humimm.2025.111341_b0085","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg7942","article-title":"Persistent complement dysregulation with signs of thromboinflammation in active long covid","volume":"383","author":"Cervia-Hasler","year":"2024","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.humimm.2025.111341_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/v15040885","article-title":"Thrombophilia and immune-related genetic markers in long COVID","volume":"15","author":"da Silva","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.humimm.2025.111341_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.922422","article-title":"Cytokine profiles associated with acute COVID-19 and long COVID-19 syndrome","volume":"12","author":"Queiroz","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0100","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1038\/s41598-024-55696-0","article-title":"Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-\u03b1","volume":"14","author":"Queiroz","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2025.111341_b0105","article-title":"Biomarkers in long COVID-19: a systematic review","volume":"10","author":"Lai","year":"2023","journal-title":"Front. Med. (Lausanne)"},{"issue":"4","key":"10.1016\/j.humimm.2025.111341_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/v16040650","article-title":"Association of the IFNG +874T\/A polymorphism with symptomatic COVID-19 susceptibility","volume":"16","author":"Sarges","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.humimm.2025.111341_b0115","unstructured":"World Health Organization, COVID-19 Clinical Management: Living Guidance, 25 January 2021, 2021, Available online: https:\/\/iris.who.int\/handle\/10665\/338882 (accessed on 23 March 2024)."},{"issue":"6","key":"10.1016\/j.humimm.2025.111341_b0120","first-page":"741","article-title":"Normalization of gene expression by quantitative RT-PCR in human cell line: comparison of 12 endogenous reference genes","volume":"28","author":"Adeola","year":"2018","journal-title":"Ethiop. J. Health Sci."},{"key":"10.1016\/j.humimm.2025.111341_b0125","unstructured":"R Core Team, R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, 2022, https:\/\/www.R-project.org\/."},{"key":"10.1016\/j.humimm.2025.111341_b0130","unstructured":"M. Ayres, J.R.M. Ayres, D.L. Ayres, et al., BioEstat 5.0: Aplica\u00e7\u00f5es Estat\u00edsticas nas \u00c1reas de Ci\u00eancias Biol\u00f3gicas e M\u00e9dicas, Sociedade Civil Mamirau\u00e1. Bras\u00edlia, CNPq, 2008."},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13073-023-01227-x","article-title":"SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile","volume":"15","author":"Zhang","year":"2023","journal-title":"Genome Med."},{"issue":"6585","key":"10.1016\/j.humimm.2025.111341_b0140","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.abm8108","article-title":"The immunology and immunopathology of COVID-19","volume":"375","author":"Merad","year":"2022","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.humimm.2025.111341_b0145","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s10517-022-05621-0","article-title":"Quantitative assay of SARS-CoV-2 RNA and level of proinflammatory protein gene transcripts in peripheral blood leukocytes after a novel coronavirus infection","volume":"173","author":"Topchieva","year":"2022","journal-title":"Bull. Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.humimm.2025.111341_b0150","article-title":"Regulatory T cells (Tregs) and COVID-19: unveiling the mechanisms, and therapeutic potentialities with a special focus on long COVID","volume":"11","author":"Dhawan","year":"2023","journal-title":"Vaccines (Basel)"},{"issue":"5","key":"10.1016\/j.humimm.2025.111341_b0155","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41418-024-01278-6","article-title":"Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality","volume":"31","author":"Albert","year":"2024","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.humimm.2025.111341_b0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12029-011-9252-6","article-title":"Tissue expression of the proteins fas and fas ligand in colorectal cancer and liver metastases","volume":"43","author":"Kykalos","year":"2012","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.humimm.2025.111341_b0165","unstructured":"F. Mollinedo, C. Gajate, FasL-independent activation of Fas, in: Madame Curie Bioscience Database (Internet), Landes Bioscience, Austin, TX, 2000\u20132013, Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6345\/."},{"issue":"2","key":"10.1016\/j.humimm.2025.111341_b0170","article-title":"SARS-CoV-2 modulation of RIG-I-MAVS signaling: potential mechanisms of impairment on host antiviral immunity and therapeutic approaches","volume":"1","author":"Wang","year":"2022","journal-title":"MedComm Futur. Med."},{"issue":"21","key":"10.1016\/j.humimm.2025.111341_b0175","doi-asserted-by":"crossref","first-page":"13344","DOI":"10.1074\/jbc.M115.653915","article-title":"Human DNA exonuclease TREX1 is also an Exoribonuclease that acts on single-stranded RNA","volume":"290","author":"Yuan","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.humimm.2025.111341_b0180","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.chom.2023.08.001","article-title":"Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection","volume":"31","author":"King","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13048-021-00787-z","article-title":"Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection","volume":"14","author":"Chaudhari","year":"2021","journal-title":"J. Ovarian Res."},{"issue":"7","key":"10.1016\/j.humimm.2025.111341_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/biom14070835","article-title":"Interplay between comorbidities and long COVID: challenges and multidisciplinary approaches","volume":"14","author":"Ashmawy","year":"2024","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010578","article-title":"Selected biomarkers of depression: what are the effects of cytokines and inflammation?","volume":"24","author":"Harsanyi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.humimm.2025.111341_b0200","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jpsychires.2022.10.045","article-title":"Psychiatric and neurological complications of long COVID","volume":"156","author":"Zawilska","year":"2022","journal-title":"J. Psychiatric Res."},{"key":"10.1016\/j.humimm.2025.111341_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111246","article-title":"Agomelatine effects on fat-enriched diet induced neuroinflammation and depression-like behavior in rats","volume":"135","author":"Rebai","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0210","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12640-021-00447-6","article-title":"Agomelatine exerts an anti-inflammatory effect by inhibiting microglial activation through TLR4\/NLRP3 pathway in pMCAO rats","volume":"40","author":"Chumboatong","year":"2022","journal-title":"Neurotox. Res."},{"issue":"2","key":"10.1016\/j.humimm.2025.111341_b0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s40267-022-00975-x","article-title":"Antidepressants with anti-inflammatory properties may be useful in long COVID depression","volume":"39","author":"Fenton","year":"2023","journal-title":"Drugs Ther. Perspect."},{"key":"10.1016\/j.humimm.2025.111341_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109646","article-title":"Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors\/SIRT1 signaling pathway","volume":"115","author":"Mahmoud","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.humimm.2025.111341_b0225","article-title":"Ocular symptoms in COVID-19 infection: a survey study","volume":"12 1","author":"McHarg","year":"2022","journal-title":"Res. Sq."},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0230","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s10194-022-01450-8","article-title":"Long COVID headache","volume":"23","author":"Tana","year":"2022","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0235","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s10194-022-01442-8","article-title":"P2X7R\/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine","volume":"23","author":"Wang","year":"2022","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0240","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/cc2950","article-title":"Bench-to-bedside review: apoptosis\/programmed cell death triggered by traumatic brain injury","volume":"9","author":"Zhang","year":"2005","journal-title":"Crit. Care"},{"key":"10.1016\/j.humimm.2025.111341_b0245","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01631","article-title":"NLRP3, NLRP12, and IFI16 inflammasomes induction and Caspase-1 activation triggered by virulent HSV-1 strains are associated with severe corneal inflammatory herpetic disease","volume":"10","author":"Coulon","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.humimm.2025.111341_b0250","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.jaci.2023.06.024","article-title":"RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent","volume":"152","author":"Navarro","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.humimm.2025.111341_b0255","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/1073858418760481","article-title":"Neural mechanisms of inflammation-induced fever","volume":"24","author":"Blomqvist","year":"2018","journal-title":"Neuroscientist"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0260","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1189\/jlb.4HI0714-338RR","article-title":"SAMHD1's protein expression profile in humans","volume":"98","author":"Schmidt","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.humimm.2025.111341_b0265","doi-asserted-by":"crossref","DOI":"10.1177\/17562848221118403","article-title":"Gastrointestinal manifestations of long COVID: a systematic review and meta-analysis","volume":"15","author":"Choudhury","year":"2022","journal-title":"Therap. Adv. Gastroenterol."},{"issue":"11","key":"10.1016\/j.humimm.2025.111341_b0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0250909","article-title":"Incidence of long-term post-acute sequelae of SARS-CoV-2 infection related to pain and other symptoms: a systematic review and meta-analysis","volume":"18","author":"Hoshijima","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2025.111341_b0275","article-title":"Spontaneous, persistent T cell-dependent IFN-\u03b3 release in patients who progress to long covid","volume":"10 8","author":"Krishna","year":"2024","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.humimm.2025.111341_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12060806","article-title":"Towards understanding long COVID: SARS-CoV-2 strikes the host cell nucleus","volume":"12","author":"Lafon-Hughes","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.humimm.2025.111341_b0285","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00325","article-title":"Regulating IRFs in IFN driven disease","volume":"10","author":"Jefferies","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.humimm.2025.111341_b0290","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0295","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1038\/s41467-022-34895-1","article-title":"Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity","volume":"13","author":"Smith","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.humimm.2025.111341_b0300","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon (corrected) gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"Honda","year":"2006","journal-title":"Immun"},{"issue":"1","key":"10.1016\/j.humimm.2025.111341_b0305","doi-asserted-by":"crossref","first-page":"21779","DOI":"10.1038\/s41598-022-26457-8","article-title":"COVID-19 plasma exosomes promote proinflammatory immune responses in peripheral blood mononuclear cells","volume":"12","author":"Chen","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925001120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885925001120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:54:17Z","timestamp":1777528457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885925001120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0198885925001120"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111341","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profile of immune response markers associated with long COVID and its clinical aspects in a cohort from northern Brazil","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2025.111341","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111341"}}