{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:55:04Z","timestamp":1781859304260,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007273","name":"Medical College, Weill Cornell Medicine","doi-asserted-by":"publisher","award":["R37 NIH MERIT AI051652"],"award-info":[{"award-number":["R37 NIH MERIT AI051652"]}],"id":[{"id":"10.13039\/100007273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R37AI151059"],"award-info":[{"award-number":["R37AI151059"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI164093"],"award-info":[{"award-number":["R21AI164093"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.humimm.2026.111687","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:40:39Z","timestamp":1771026039000},"page":"111687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1116-8243","authenticated-orcid":false,"given":"Andreas","family":"Stephanou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhav","family":"Mantri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8028-9618","authenticated-orcid":false,"given":"Divya","family":"Shankaranarayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila","family":"Lagman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chendong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-6209","authenticated-orcid":false,"given":"Thangamani","family":"Muthukumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Machaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwijn","family":"De Vlaminck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikkam","family":"Suthanthiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2026.111687_b0005","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/31960","article-title":"Calcium oscillations increase the efficiency and specificity of gene expression","volume":"392","author":"Dolmetsch","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2026.111687_b0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/341197a0","article-title":"Inositol phosphates and cell signalling","volume":"341","author":"Berridge","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2026.111687_b0015","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/physrev.00020.2014","article-title":"Store-Operated Calcium Channels","volume":"95","author":"Prakriya","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.humimm.2026.111687_b0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.immunol.021908.132550","article-title":"Molecular basis of calcium signaling in lymphocytes: STIM and ORAI","volume":"28","author":"Hogan","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0025","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMoa0900082","article-title":"STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity","volume":"360","author":"Picard","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.humimm.2026.111687_b0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.clim.2010.01.011","article-title":"Immunodeficiency due to mutations in ORAI1 and STIM1","volume":"135","author":"Feske","year":"2010","journal-title":"Clin. Immunol. Orlando Fla"},{"key":"10.1016\/j.humimm.2026.111687_b0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","article-title":"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2026.111687_b0040","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1101\/gad.11.7.824","article-title":"Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction","volume":"11","author":"Beals","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.humimm.2026.111687_b0045","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41467-017-00612-6","article-title":"NFATc1 controls the cytotoxicity of CD8+ T cells","volume":"8","author":"Klein-Hessling","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.humimm.2026.111687_b0050","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fimmu.2019.00184","article-title":"NFAT1 and NFAT2 Differentially Regulate CTL Differentiation upon Acute Viral Infection","volume":"10","author":"Xu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0055","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ni1549","article-title":"Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer","volume":"9","author":"Tone","year":"2008","journal-title":"Nat. Immunol."},{"issue":"179","key":"10.1016\/j.humimm.2026.111687_b0060","first-page":"3831","article-title":"Induction of the CTLA-4 Gene in Human Lymphocytes is Dependent on NFAT Binding the Proximal Promoter","volume":"1950","author":"Gibson","year":"2007","journal-title":"J. Immunol. Baltim. Md"},{"key":"10.1016\/j.humimm.2026.111687_b0065","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1113\/JP277856","article-title":"The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis","volume":"597","author":"Waldron","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.humimm.2026.111687_b0070","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqae017","article-title":"Combination of the CRAC Channel Inhibitor CM4620 and Galactose as a potential Therapy for Acute Pancreatitis","volume":"5","author":"Lewis","year":"2024","journal-title":"Function"},{"key":"10.1016\/j.humimm.2026.111687_b0075","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/MPA.0000000000001793","article-title":"Auxora for the Treatment of patients with Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor","volume":"50","author":"Bruen","year":"2021","journal-title":"Pancreas"},{"key":"10.1016\/j.humimm.2026.111687_b0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4161\/chan.25292","article-title":"Molecular pharmacology of store-operated CRAC channels","volume":"7","author":"Jairaman","year":"2013","journal-title":"Channels"},{"key":"10.1016\/j.humimm.2026.111687_b0085","article-title":"The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle","volume":"153","author":"Meizoso-Huesca","year":"2020","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.humimm.2026.111687_b0090","doi-asserted-by":"crossref","first-page":"10997","DOI":"10.1074\/jbc.M411797200","article-title":"A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2","volume":"280","author":"He","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.humimm.2026.111687_b0095","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.pupt.2007.09.003","article-title":"The suppressive effects of YM-58483\/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo","volume":"21","author":"Ohga","year":"2008","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.humimm.2026.111687_b0100","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.intimp.2008.08.016","article-title":"Characterization of YM-58483\/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo","volume":"8","author":"Ohga","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.humimm.2026.111687_b0105","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2007.01.012","article-title":"YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models","volume":"560","author":"Yoshino","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.humimm.2026.111687_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2024.111144","article-title":"Blockade of store-operated calcium entry by BTP2 preserves anti-inflammatory gene expression in human peripheral blood mononuclear cells","volume":"85","author":"Shankaranarayanan","year":"2024","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0115","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/s41467-021-21892-z","article-title":"Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis","volume":"12","author":"Mantri","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.humimm.2026.111687_b0120","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s44161-022-00138-1","article-title":"Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis","volume":"1","author":"Mantri","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.humimm.2026.111687_b0125","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8374328","article-title":"Altered Intracellular ATP Production by Activated CD4+ T-Cells in very Preterm infants","volume":"2016","author":"Aquilano","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.humimm.2026.111687_b0130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1034\/j.1399-0012.2003.00013.x","article-title":"Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management","volume":"17","author":"Kowalski","year":"2003","journal-title":"Clin. Transplant."},{"key":"10.1016\/j.humimm.2026.111687_b0135","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/JLB.3A1020-630RR","article-title":"Activation of human \u03b3\u03b4 T cells and NK cells by Staphylococcal enterotoxins requires both monocytes and conventional T cells","volume":"111","author":"Mata Forsberg","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.humimm.2026.111687_b0140","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.4049\/jimmunol.2300731","article-title":"NK Cell\u2013Monocyte Cross-talk Underlies NK Cell Activation in Severe COVID-19","volume":"212","author":"Lee","year":"2024","journal-title":"J. Immunol. Author Choice"},{"key":"10.1016\/j.humimm.2026.111687_b0145","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fimmu.2012.00403","article-title":"Consequences of the crosstalk between monocytes\/macrophages and natural killer cells","volume":"3","author":"Michel","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.636720","article-title":"Single Cell Analysis of Blood Mononuclear Cells Stimulated through either LPS or Anti-CD3 and Anti-CD28","volume":"12","author":"Lawlor","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0155","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1479-5876-8-104","article-title":"Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation","volume":"8","author":"Li","year":"2010","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.humimm.2026.111687_b0160","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.immuni.2017.09.003","article-title":"Store-Operated Ca2+ Entry Controls Clonal expansion of T Cells through Metabolic Reprogramming","volume":"47","author":"Vaeth","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2026.111687_b0165","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.it.2020.06.012","article-title":"CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity","volume":"41","author":"Vaeth","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0170","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1074\/jbc.M309297200","article-title":"Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2","volume":"279","author":"Zitt","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.humimm.2026.111687_b0175","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202215687","article-title":"Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease","volume":"14","author":"Letizia","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.humimm.2026.111687_b0180","doi-asserted-by":"crossref","unstructured":"Lyu, H. et al. Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs. eLife 12, RP88874.","DOI":"10.7554\/eLife.88874"},{"key":"10.1016\/j.humimm.2026.111687_b0185","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1632","article-title":"NFAT proteins: key regulators of T-cell development and function","volume":"5","author":"Macian","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0190","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.humimm.2026.111687_b0195","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2006.05.042","article-title":"FOXP3 controls regulatory T cell function through cooperation with NFAT","volume":"126","author":"Wu","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2026.111687_b0200","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.immuni.2014.10.012","article-title":"Continuous T cell receptor signals maintain a functional regulatory T cell pool","volume":"41","author":"Vahl","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2026.111687_b0205","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/TP.0000000000004896","article-title":"RNA-sequencing of Human Kidney Allografts and Delineation of T-Cell Genes, Gene Sets, and Pathways Associated with Acute T Cell-mediated rejection","volume":"108","author":"Mueller","year":"2024","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2026.111687_b0210","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa051907","article-title":"Messenger RNA for FOXP3 in the urine of renal-allograft recipients","volume":"353","author":"Muthukumar","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.humimm.2026.111687_b0215","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cei.12981","article-title":"Operational tolerance in kidney transplantation and associated biomarkers","volume":"189","author":"Massart","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.humimm.2026.111687_b0220","doi-asserted-by":"crossref","unstructured":"Chawla, L. S. et al. Inhibition of Calcium Release-Activated Calcium Channels to Treat Acute Kidney Injury: Design and Rationale of the KOURAGE Study a Randomized Trial. Am. J. Nephrol. https:\/\/doi.org\/10.1159\/000546863 (2025) doi:10.1159\/000546863.","DOI":"10.1159\/000546863"},{"key":"10.1016\/j.humimm.2026.111687_b0225","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinforma. Oxf. Engl."},{"key":"10.1016\/j.humimm.2026.111687_b0230","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"Suppl 1","key":"10.1016\/j.humimm.2026.111687_b0235","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1093\/bioinformatics\/18.suppl_1.S96","article-title":"Variance stabilization applied to microarray data calibration and to the quantification of differential expression","volume":"18","author":"Huber","year":"2002","journal-title":"Bioinforma. Oxf. Engl."},{"key":"10.1016\/j.humimm.2026.111687_b0240","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/01621459.1988.10478610","article-title":"Estimating Transformations for Regression via Additivity and Variance Stabilization","volume":"83","author":"Tibshirani","year":"1988","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.humimm.2026.111687_b0245","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/bioinformatics\/bty895","article-title":"Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences","volume":"35","author":"Zhu","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.humimm.2026.111687_b0250","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.humimm.2026.111687_b0255","doi-asserted-by":"crossref","DOI":"10.1126\/science.abl5197","article-title":"Cross-tissue immune cell analysis reveals tissue-specific features in humans","volume":"376","author":"Dom\u00ednguez Conde","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.humimm.2026.111687_b0260","article-title":"PyDESeq2: a python package for bulk RNA-seq differential expression analysis","volume":"39","author":"Muzellec","year":"2023","journal-title":"Bioinforma. Oxf. Engl."},{"key":"10.1016\/j.humimm.2026.111687_b0265","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.humimm.2026.111687_b0270","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"GSEApy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.humimm.2026.111687_b0275","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2026.111687_b0280","unstructured":"The Gene Ontology Consortium et al. The Gene Ontology knowledgebase in 2023. Genetics 224, iyad031 (2023)."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885926000339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885926000339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:25:45Z","timestamp":1781857545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885926000339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0198885926000339"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2026.111687","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2026.111687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.","name":"copyright","label":"Copyright"}],"article-number":"111687"}}