{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:07:35Z","timestamp":1779340055381,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.humimm.2026.111709","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T08:29:24Z","timestamp":1772872164000},"page":"111709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of IL4 and IL17A genetic polymorphisms with COVID-19 severity in a southern Brazilian population"],"prefix":"10.1016","volume":"87","author":[{"given":"Manuela Nunes","family":"Drehmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-4952","authenticated-orcid":false,"given":"Gabriel Vaisam","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Delacanal","family":"Lazzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano Santos","family":"Pinto Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius de Albuquerque","family":"Sortica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia Gon\u00e7alves","family":"Possuelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia Rosane de","family":"Moura Valim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Souza da","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izza","family":"Gambin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8394-1559","authenticated-orcid":false,"given":"Julia Pasqualini","family":"Genro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara Costa","family":"Netto Muniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-9820","authenticated-orcid":false,"given":"Juliana Dal-Ri","family":"Lindenau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2026.111709_b0005","doi-asserted-by":"crossref","unstructured":"T.K. Boehmer, J. DeVies, E. Caruso, K.L. van Santen, S. Tang, C.L. Black, K.P. Hartnett, A. Kite-Powell, S. Dietz, M. Lozier, A. V. Gundlapalli, Changing Age Distribution of the COVID-19 Pandemic \u2014 United States, May\u2013August 2020, MMWR Morb. Mortal. Wkly. Rep. 69 (2020) 1404\u20131409. Doi: 10.15585\/mmwr.mm6939e1.","DOI":"10.15585\/mmwr.mm6939e1"},{"key":"10.1016\/j.humimm.2026.111709_b0010","article-title":"Hospital outcomes for young adults with COVID-19","volume":"8","author":"Williams","year":"2024","journal-title":"Glob. Epidemiol."},{"key":"10.1016\/j.humimm.2026.111709_b0015","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hep4.1790","article-title":"COVID\u201019 and the Uncovering of Health Care Disparities in the United States, United Kingdom and Canada: Call to Action","volume":"5","author":"Ala","year":"2021","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.humimm.2026.111709_b0020","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3390\/medicina58020144","article-title":"Cytokine storm in COVID-19: Immunopathogenesis and Therapy","volume":"58","author":"Zanza","year":"2022","journal-title":"Medicina (b Aires)."},{"key":"10.1016\/j.humimm.2026.111709_b0025","doi-asserted-by":"crossref","unstructured":"L. Karcioglu Batur, N. Hekim, Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID\u20102019) in 23 countries, J. Med. Virol. 93 (2021) 5853\u20135863. Doi: 10.1002\/jmv.27127.","DOI":"10.1002\/jmv.27127"},{"key":"10.1016\/j.humimm.2026.111709_b0030","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s44197-024-00204-w","article-title":"Impacts of Inflammatory Cytokines Variants on Systemic Inflammatory Profile and COVID-19 Severity","volume":"14","author":"Deng","year":"2024","journal-title":"J. Epidemiol. Glob. Health"},{"key":"10.1016\/j.humimm.2026.111709_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00888","article-title":"Tuning the Cytokine responses: an Update on Interleukin (IL)-4 and IL-13 Receptor Complexes","volume":"9","author":"Junttila","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2026.111709_b0040","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3390\/ijms23031112","article-title":"Cytokine Receptors\u2014Regulators of Antimycobacterial Immune Response","volume":"23","author":"Druszczy\u0144ska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.humimm.2026.111709_b0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/gene.2016.47","article-title":"Functionality and opposite roles of two interleukin 4 haplotypes in immune cells","volume":"18","author":"Anovazzi","year":"2017","journal-title":"Genes Immun."},{"key":"10.1016\/j.humimm.2026.111709_b0050","doi-asserted-by":"crossref","first-page":"892","DOI":"10.4049\/jimmunol.2000554","article-title":"A Case for Targeting Th17 Cells and IL-17A in SARS-CoV-2 Infections","volume":"205","author":"Orlov","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2026.111709_b0055","first-page":"L6","article-title":"IL-17 in the lung: the good, the bad, and the ugly, American Journal of Physiology-Lung Cellular and Molecular","volume":"314","author":"Gurczynski","year":"2018","journal-title":"Physiology"},{"key":"10.1016\/j.humimm.2026.111709_b0060","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/CCM.0000000000001409","article-title":"Interleukin-17A is Associated with Alveolar Inflammation and Poor Outcomes in Acute respiratory Distress Syndrome","volume":"44","author":"Mikacenic","year":"2016","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.humimm.2026.111709_b0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/sji.12408","article-title":"Blockade of Interleukin\u201017 Restrains the Development of Acute Lung Injury","volume":"83","author":"Li","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.humimm.2026.111709_b0070","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","article-title":"Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-\u03b1 and Granulocyte Colony-Stimulating factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis","volume":"175","author":"McAllister","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2026.111709_b0075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1465-9921-11-177","article-title":"Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients","volume":"11","author":"Decraene","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.humimm.2026.111709_b0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jim.2016.04.008","article-title":"Positive fungal quantitative PCR and Th17 cytokine detection in bronchoalveolar lavage fluids: Complementary biomarkers of hypersensitivity pneumonitis?","volume":"434","author":"Bellanger","year":"2016","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.humimm.2026.111709_b0085","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1067\/mai.2003.1557","article-title":"Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-\u03b2, IL-11, IL-17, and type I and type III collagen expression","volume":"111","author":"Chakir","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.humimm.2026.111709_b0090","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jtho.2017.04.017","article-title":"Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade","volume":"12","author":"Akbay","year":"2017","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.humimm.2026.111709_b0095","first-page":"1","article-title":"Genetic polymorphisms of IL17A , TLR4 and P2RX7 and associations with the risk of chronic obstructive pulmonary disease, Mutation Research\/Genetic Toxicology and Environmenta","volume":"829\u2013830","author":"Dai","year":"2018","journal-title":"Mutagenesis"},{"key":"10.1016\/j.humimm.2026.111709_b0100","doi-asserted-by":"crossref","first-page":"40666","DOI":"10.1038\/srep40666","article-title":"The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina","volume":"7","author":"Rolandelli","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2026.111709_b0105","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/CM9.0000000000000819","article-title":"Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)","volume":"133","author":"Wei","year":"2020","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.humimm.2026.111709_b0110","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.humimm.2026.111709_b0115","doi-asserted-by":"crossref","unstructured":"L.M. Rossen, A.M. Branum, F.B. Ahmad, P. Sutton, R.N. Anderson, Excess Deaths Associated with COVID-19, by Age and Race and Ethnicity \u2014 United States, January 26\u2013October 3, 2020, MMWR Morb. Mortal. Wkly. Rep. 69 (2020) 1522\u20131527. Doi: 10.15585\/mmwr.mm6942e2.","DOI":"10.15585\/mmwr.mm6942e2"},{"key":"10.1016\/j.humimm.2026.111709_b0120","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s10654-020-00698-1","article-title":"Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications","volume":"35","author":"Levin","year":"2020","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.humimm.2026.111709_b0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis","volume":"94","author":"Yang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.humimm.2026.111709_b0130","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1186\/s12879-021-06536-3","article-title":"Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients","volume":"21","author":"Dessie","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.humimm.2026.111709_b0135","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/23744235.2020.1772992","article-title":"Time course of anosmia and dysgeusia in patients with mild SARS-CoV-2 infection","volume":"52","author":"Levinson","year":"2020","journal-title":"Infect. Dis."},{"key":"10.1016\/j.humimm.2026.111709_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/2755246","article-title":"Associations between Serum Interleukins (IL-1\u03b2, IL-2, IL-4, IL-6, IL-8, and IL-10) and Disease Severity of COVID-19: a Systematic Review and Meta-Analysis","volume":"2022","author":"Chang","year":"2022","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.humimm.2026.111709_b0145","doi-asserted-by":"crossref","DOI":"10.12703\/r\/10-71","article-title":"Recent advances in understanding the role of IL-4 signaling","volume":"10","author":"Keegan","year":"2021","journal-title":"Fac. Rev."},{"key":"10.1016\/j.humimm.2026.111709_b0150","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.molimm.2009.10.025","article-title":"The interleukin-4 \u221234TT and \u2212590TT genotype is correlated with increased expression and protein production in aggressive periodontitis","volume":"47","author":"Gonzales","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.humimm.2026.111709_b0155","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12985-022-01814-1","article-title":"COVID-19 infection: an overview on cytokine storm and related interventions","volume":"19","author":"Montazersaheb","year":"2022","journal-title":"Virol. J."},{"key":"10.1016\/j.humimm.2026.111709_b0160","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2026.111709_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026229","article-title":"A Genetic Variant in the IL-17 Promoter is Functionally Associated with Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation","volume":"6","author":"Espinoza","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2026.111709_b0170","doi-asserted-by":"crossref","first-page":"52762","DOI":"10.1074\/jbc.M405764200","article-title":"Crucial Role for Nuclear factor of Activated T Cells in T Cell Receptor-mediated Regulation of Human Interleukin-17","volume":"279","author":"Liu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.humimm.2026.111709_b0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12985-019-1187-8","article-title":"Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A\/H1N1 and B in an iranian population","volume":"16","author":"Keshavarz","year":"2019","journal-title":"Virol. J."},{"key":"10.1016\/j.humimm.2026.111709_b0180","first-page":"286","article-title":"Polymorphisms in the IL-17 Gene (rs2275913 and rs763780) are Associated with Hepatitis B Virus Infection in the Han Chinese Population, Genet. Test. Mol","volume":"21","author":"Ren","year":"2017","journal-title":"Biomarkers"},{"key":"10.1016\/j.humimm.2026.111709_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156445","article-title":"Impact of IL-6 rs1800795 and IL-17A rs2275913 gene polymorphisms on the COVID-19 prognosis and susceptibility in a sample of iranian patients","volume":"174","author":"Khafaei","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.humimm.2026.111709_b0190","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1038\/s41598-020-61965-5","article-title":"Genetic polymorphisms of IL17A associated with Chagas disease: results from a meta-analysis in Latin American populations","volume":"10","author":"Strauss","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2026.111709_b0195","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1016\/j.jinf.2020.05.072","article-title":"Interleukin-17: a potential therapeutic target in COVID-19","volume":"81","author":"Mendoza","year":"2020","journal-title":"J. Infect."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885926000558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885926000558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:15:35Z","timestamp":1779336935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885926000558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0198885926000558"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2026.111709","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of IL4 and IL17A genetic polymorphisms with COVID-19 severity in a southern Brazilian population","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2026.111709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.","name":"copyright","label":"Copyright"}],"article-number":"111709"}}