{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:27:29Z","timestamp":1771550849924,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.humpath.2006.09.003","type":"journal-article","created":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T12:58:14Z","timestamp":1168520294000},"page":"400-409","source":"Crossref","is-referenced-by-count":40,"title":["FOXG1 is overexpressed in hepatoblastoma"],"prefix":"10.1016","volume":"38","author":[{"given":"Adekunle Michael","family":"Adesina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yummy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preethi","family":"Guanaratne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Pulliam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Lopez-Terrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Margolin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton","family":"Finegold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2006.09.003_bib1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0959-8049(99)00049-0","article-title":"Liver tumours","volume":"35","author":"Perilongo","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.humpath.2006.09.003_bib2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1440-1827.1996.tb03581.x","article-title":"Hepatoblastoma in an adult associated with c-met protooncogene imbalance","volume":"46","author":"Kuniyasu","year":"1996","journal-title":"Pathol Int"},{"key":"10.1016\/j.humpath.2006.09.003_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3346\/jkms.1997.12.4.369","article-title":"Mixed hepatoblastoma in an adult\u2014a case report and literature review","volume":"12","author":"Ahn","year":"1997","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.humpath.2006.09.003_bib4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/00000478-199711000-00015","article-title":"Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma","volume":"21","author":"Parada","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2006.09.003_bib5","series-title":"Principles and practice of pediatric oncology","first-page":"887","article-title":"Tumors of the liver","author":"Mueller","year":"2006"},{"key":"10.1016\/j.humpath.2006.09.003_bib6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/mpo.10176","article-title":"Hepatoblastoma and low birth weight: a trend or chance observation?","volume":"39","author":"Feusner","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.humpath.2006.09.003_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/gcc.20227","article-title":"Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21","volume":"44","author":"Tomlinson","year":"2005","journal-title":"Genes, Chromosomes Cancer"},{"key":"10.1016\/j.humpath.2006.09.003_bib8","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S0046-8177(03)00351-4","article-title":"Comparative genomic hybridization analysis of hepatoblastoma reveals high frequency of X-chromosome gains and similarities between epithelial and stromal components","volume":"34","author":"Terracciano","year":"2003","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2006.09.003_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ydbio.2005.04.005","article-title":"FOXG1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis","volume":"283","author":"Martynoga","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.humpath.2006.09.003_bib10","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1523\/JNEUROSCI.4804-04.2005","article-title":"FOXG1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium","volume":"25","author":"Muzio","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.humpath.2006.09.003_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.1090674","article-title":"FOXG1 suppresses early cortical cell fate","volume":"303","author":"Hanachima","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.humpath.2006.09.003_bib12","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1128\/MCB.20.17.6201-6211.2000","article-title":"BF-1 interferes with transforming growth factor \u03b2 signaling by associating with smad partners","volume":"20","author":"Dou","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.humpath.2006.09.003_bib13","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1242\/dev.125.24.4889","article-title":"XBF-1, a winged helix transcription factor with dual activity has a role in positioning neurogenesis in Xenopus competent ectoderm","volume":"125","author":"Bourguignon","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.humpath.2006.09.003_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/neu.10287","article-title":"Excess FOXG1 causes overgrowth of the neural tube","volume":"57","author":"Ahlgren","year":"2003","journal-title":"J Neurobiol"},{"key":"10.1016\/j.humpath.2006.09.003_bib15","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S1097-2765(04)00213-8","article-title":"Fox O: linking new signaling pathways","volume":"14","author":"Arden","year":"2004","journal-title":"Mol Cell"},{"key":"10.1016\/j.humpath.2006.09.003_bib16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0046-8177(83)80005-7","article-title":"Primary hepatic tumors of childhood","volume":"14","author":"Weinberg","year":"1983","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2006.09.003_bib17","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/30.4.e15","article-title":"Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation","volume":"30","author":"Yang","year":"2002","journal-title":"Nuclei Acid Res"},{"key":"10.1016\/j.humpath.2006.09.003_bib18","series-title":"Data analysis tools for microarrays","first-page":"309","article-title":"Data pre-processing and normalization","author":"Draghici","year":"2003"},{"key":"10.1016\/j.humpath.2006.09.003_bib19","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2006.09.003_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/gcc.2870110309","article-title":"Trisomy 2, trisomy 20, and del(17p) as sole chromosomal abnormalities in three cases of hepatoblastoma","volume":"11","author":"Tonk","year":"1994","journal-title":"Genes Chromosome Cancer"},{"key":"10.1016\/j.humpath.2006.09.003_bib21","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0165-4608(00)00323-X","article-title":"Trisomy 1q, 2, and 20 in a case of hepatoblastoma: possible significance of 2q35-q37 and 1q12-q21 rearrangements","volume":"123","author":"Yeh","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.humpath.2006.09.003_bib22","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1349-7006.2001.tb01172.x","article-title":"Frequent increase of DNA copy number in the 2q24 chromosomal region and its association with a poor clinical outcome in hepatoblastoma: cytogenetic and comparative genomic hybridization analysis","volume":"92","author":"Kumon","year":"2001","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.humpath.2006.09.003_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0165-4608(99)00203-4","article-title":"Cytogenetic characterization of childhood hepatoblastoma","volume":"119","author":"Ma","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.humpath.2006.09.003_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0165-4608(99)00033-3","article-title":"Karyotypic analyses of hepatoblastoma. Report of two cases and review of the literature suggesting chromosomal loci responsible for the pathogenesis of this disease","volume":"114","author":"Nagata","year":"1999","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.humpath.2006.09.003_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/(SICI)1096-911X(200003)34:3<165::AID-MPO1>3.0.CO;2-T","article-title":"Cytogenetics of hepatoblastoma: further characterization of 1q rearrangements by fluorescence in situ hybridization: an international collaborative study","volume":"34","author":"Parada","year":"2000","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.humpath.2006.09.003_bib26","first-page":"86","article-title":"Trisomy 2 and 19, and tetrasomy 1q and 14 in hepatoblastoma","volume":"115","author":"Park","year":"1999","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.humpath.2006.09.003_bib27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1098-2264(199708)19:4<291::AID-GCC13>3.0.CO;2-J","article-title":"The first recurring chromosome translocation in hepatoblastoma: der(4)t(1;4)(q12;q34)","volume":"19","author":"Schneider","year":"1997","journal-title":"Genes Chromosome Cancer"},{"key":"10.1016\/j.humpath.2006.09.003_bib28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/mpo.10180","article-title":"Genetic alterations in hepatoblastoma and hepatocellular carcinoma: common and distinctive aspects","volume":"39","author":"Buendia","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.humpath.2006.09.003_bib29","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1096\/fasebj.9.15.8529831","article-title":"Role of growth factors and cytokines in hepatic regeneration","volume":"9","author":"Fausto","year":"1995","journal-title":"FASEB J"},{"key":"10.1016\/j.humpath.2006.09.003_bib30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1053\/jhep.2000.9145","article-title":"Regulatory mechanisms for transforming growth factor beta as an autocrine inhibitor in human hepatocellular carcinoma: implications for roles of smads in its growth","volume":"32","author":"Matsuzaki","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.humpath.2006.09.003_bib31","first-page":"760","article-title":"Transforming growth factor-beta 1 (TGF-\u03b21) and TGF-\u03b21 receptors in normal, cirrhotic, and neoplastic human livers","volume":"21","author":"Bedossa","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.humpath.2006.09.003_bib32","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/1097-0142(19940501)73:9<2275::AID-CNCR2820730907>3.0.CO;2-T","article-title":"Plasma transforming growth factor-\u03b21 in patients with hepatocellular carcinoma","volume":"73","author":"Shirai","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2006.09.003_bib33","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","article-title":"Wnt signaling and cancer","volume":"14","author":"Polakis","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.humpath.2006.09.003_bib34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s003830000576","article-title":"High frequency of beta-catenin mutations in hepatoblastoma","volume":"17","author":"Udatsu","year":"2001","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.humpath.2006.09.003_bib35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1386-6346(02)00264-4","article-title":"Sequence variants of the Axin gene in hepatoblastoma","volume":"25","author":"Miao","year":"2003","journal-title":"Hepatol Res"},{"key":"10.1016\/j.humpath.2006.09.003_bib36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<399::AID-GCC14>3.0.CO;2-X","article-title":"Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma","volume":"25","author":"Blaker","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.humpath.2006.09.003_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3835(99)00433-4","article-title":"Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma","volume":"152","author":"Jeng","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2006.09.003_bib38","first-page":"269","article-title":"Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene","volume":"59","author":"Koch","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2006.09.003_bib39","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.onc.1203356","article-title":"Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas","volume":"19","author":"Wei","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2006.09.003_bib40","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1126\/science.1071549","article-title":"The promise and perils of Wnt signaling through beta-catenin","volume":"296","author":"Moon","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humpath.2006.09.003_bib41","first-page":"1452","article-title":"Transforming growth factor \u03b2 and cell cycle regulation","volume":"55","author":"Alexandrow","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2006.09.003_bib42","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1128\/MCB.19.9.5913","article-title":"Myc downregulation by transforming growth factor b required for activation of the p15Ink4b G1 arrest pathway","volume":"19","author":"Warner","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.humpath.2006.09.003_bib43","first-page":"307","article-title":"Somatic mutations in the kinase domain of the Met\/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas","volume":"59","author":"Park","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2006.09.003_bib44","first-page":"2064","article-title":"Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes","volume":"62","author":"Monga","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2006.09.003_bib45","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1073\/pnas.92.11.5067","article-title":"Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex","volume":"92","author":"Jou","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.humpath.2006.09.003_bib46","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/mpo.10175","article-title":"Stem-like cells in hepatoblastoma","volume":"39","author":"Ruck","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.humpath.2006.09.003_bib47","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1210\/er.21.2.115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"Manolagas","year":"2000","journal-title":"Endocr Rev"},{"key":"10.1016\/j.humpath.2006.09.003_bib48","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1242\/jcs.114.11.2085","article-title":"Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation","volume":"114","author":"Spinella-Jaegle","year":"2001","journal-title":"J Cell Sci"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817706005648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817706005648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T10:04:22Z","timestamp":1683713062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817706005648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0046817706005648"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2006.09.003","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}