{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:54:28Z","timestamp":1763765668163},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.humpath.2007.02.009","type":"journal-article","created":{"date-parts":[[2007,6,11]],"date-time":"2007-06-11T13:04:30Z","timestamp":1181567070000},"page":"1402-1411","source":"Crossref","is-referenced-by-count":38,"title":["Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates"],"prefix":"10.1016","volume":"38","author":[{"given":"Knut","family":"Engels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Oeschger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin-Leo","family":"Hansmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hillebrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Kriener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2007.02.009_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s004280050440","article-title":"Guidelines for subtyping small B-cell lymphomas in bone marrow biopsies","volume":"435","author":"Henrique","year":"1999","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2007.02.009_bib2","series-title":"Bone marrow pathology","author":"Bain","year":"1996"},{"key":"10.1016\/j.humpath.2007.02.009_bib3","series-title":"Integrative hematopathology","first-page":"403","article-title":"Bone marrow pathology","author":"Foucar","year":"1995"},{"key":"10.1016\/j.humpath.2007.02.009_bib4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/jcp.52.4.294","article-title":"Focal lymphoid aggregates (nodules) in bone marrow biopsies: differentiation between benign hyperplasia and malignant lymphoma\u2014a practical guideline","volume":"52","author":"Thiele","year":"1999","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib5","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/jcp.53.11.835","article-title":"Evaluation of B cell lymphoid infiltrates in bone marrow biopsies by morphology, immunohistochemistry, and molecular analysis","volume":"53","author":"Maes","year":"2000","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/03009740310003884","article-title":"Analysis of B-cell clonality in the hepatic tissue of patients with Sjogren's syndrome","volume":"32","author":"Tokuno","year":"2003","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.humpath.2007.02.009_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/ar68","article-title":"Clonal expansion is a characteristic feature of the B-cell repertoire of patients with rheumatoid arthritis","volume":"2","author":"Itoh","year":"1999","journal-title":"Arthritis Res"},{"key":"10.1016\/j.humpath.2007.02.009_bib8","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1006\/bcmd.2001.0442","article-title":"The dual association between lymphoma and autoimmunity","volume":"27","author":"Ehrenfeld","year":"2001","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.humpath.2007.02.009_bib9","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/art.10939","article-title":"Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives","volume":"48","author":"Ekstrom","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humpath.2007.02.009_bib10","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00002281-200405000-00014","article-title":"Rheumatoid arthritis and malignant lymphomas","volume":"16","author":"Baecklund","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.humpath.2007.02.009_bib11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/jcp.43.5.429","article-title":"Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimens","volume":"43","author":"McCarthy","year":"1990","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0002-9440(10)65132-2","article-title":"Detection of immunoglobulin kappa light chain rearrangements by polymerase chain reaction. An improved method for detecting clonal B-cell lymphoproliferative disorders","volume":"155","author":"Gong","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1053\/hupa.2000.8445","article-title":"PCR analysis of IgH-gene rearrangements in small lymphoid infiltrates microdissected from sections of paraffin-embedded bone marrow biopsy specimens","volume":"31","author":"Kremer","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00189923","article-title":"PCR-based assays for the detection of monoclonality in non-Hodgkin's lymphoma: application to formalin-fixed, paraffin-embedded tissue and decalcified bone marrow samples","volume":"73","author":"Weirich","year":"1995","journal-title":"J Mol Med"},{"key":"10.1016\/j.humpath.2007.02.009_bib15","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/ajcp\/102.6.850","article-title":"Detection of monoclonal B-cell populations in decalcified, plastic-embedded bone marrow biopsies with the polymerase chain reaction","volume":"102","author":"Fend","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib16","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2007.02.009_bib17","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/gut.2005.080523","article-title":"Wotherspoon criteria combined with B cell clonality analysis by advanced polymerase chain reaction technology discriminates covert gastric marginal zone lymphoma from chronic gastritis","volume":"55","author":"Hummel","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2007.02.009_bib18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/10428190500305380","article-title":"Evaluation of B-cell clonality in archival skin biopsy samples of cutaneous B-cell lymphoma by immunoglobulin heavy chain gene polymerase chain reaction","volume":"47","author":"Lukowsky","year":"2006","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2007.02.009_bib19","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S1525-1578(10)60591-0","article-title":"Application of BIOMED-2 primers in fixed and decalcified bone marrow biopsies: analysis of immunoglobulin H receptor rearrangements in B-cell non-Hodgkin's lymphomas","volume":"7","author":"Lassmann","year":"2005","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.humpath.2007.02.009_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2141.1989.tb04286.x","article-title":"In situ immunophenotyping of lymphocytes in human bone marrow: an immunohistochemical study","volume":"71","author":"Horny","year":"1989","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2007.02.009_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s002920050071","article-title":"Histological processing of iliac crest biopsies based on decalcification and paraffin embedding with reference to osteolytic and hematologic diagnosis","volume":"16","author":"Schaefer","year":"1995","journal-title":"Pathologe"},{"key":"10.1016\/j.humpath.2007.02.009_bib22","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/path.2134","article-title":"Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker","volume":"211","author":"Engels","year":"2007","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/mp.53.4.194","article-title":"Limitations of clonality analysis of B cell proliferations using CDR3 polymerase chain reaction","volume":"53","author":"Hoeve","year":"2000","journal-title":"Mol Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/10428190009148856","article-title":"The use of archival bone marrow specimens in detecting B-cell non-Hodgkin's lymphomas using polymerase chain reaction methods","volume":"36","author":"Nagasaka","year":"2000","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2007.02.009_bib25","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/00000478-199709000-00009","article-title":"Correlation of PCR-detected clonal gene rearrangements with bone marrow morphology in patients with B-lineage lymphomas","volume":"21","author":"Coad","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib26","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1309\/NPQXQV82Q0R8VBKT","article-title":"Contribution of IgH-PCR to the evaluation of B-cell lymphoma involvement in paraffin-embedded bone marrow biopsy specimens","volume":"119","author":"Braunschweig","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib27","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/jcp.52.7.521","article-title":"Reactive and neoplastic lymphocytes in human bone marrow: morphological, immunohistological, and molecular biological investigations on biopsy specimens","volume":"52","author":"Kr\u00f6ber","year":"1999","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/(SICI)1096-8652(199811)59:3<252::AID-AJH14>3.0.CO;2-C","article-title":"Multiple lymphoid nodules in bone marrow have the same clonality as underlying myelodysplastic syndrome recognized with fluorescent in situ hybridization technique","volume":"59","author":"Mongkonsritragoon","year":"1998","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2007.02.009_bib29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1046\/j.1365-2141.1998.00797.x","article-title":"Patients with high-risk myelodysplastic syndrome can have polyclonal or clonal haemopoiesis in complete haematological remission","volume":"102","author":"Delforge","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2007.02.009_bib30","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1002\/j.1460-2075.1993.tb06189.x","article-title":"Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections","volume":"12","author":"K\u00fcppers","year":"1993","journal-title":"Embo J"},{"key":"10.1016\/j.humpath.2007.02.009_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00019606-200009000-00002","article-title":"Clonal proliferation of B lymphocytes in the germinal centers of human reactive lymph nodes: possibility of overdiagnosis of B cell clonal proliferation","volume":"9","author":"Iijima","year":"2000","journal-title":"Diagn Mol Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib32","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.162.5.3053","article-title":"Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis","volume":"162","author":"Kim","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2007.02.009_bib33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1073\/pnas.93.1.221","article-title":"Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis","volume":"93","author":"Schr\u00f6der","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2007.02.009_bib34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/03009740310000346","article-title":"Clonal analysis of B cells in the synovial membrane of patients with rheumatoid arthritis","volume":"32","author":"Shiokawa","year":"2003","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.humpath.2007.02.009_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/ar68","article-title":"Clonal expression is a characteristic feature of the B-cell repetoire of patients with rheumatoid arthritis","volume":"2","author":"Itoh","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1016\/j.humpath.2007.02.009_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/08916939908993856","article-title":"The B lymphocyte in rheumatoid arthritis: recirculation of B lymphocytes between different joints and blood","volume":"31","author":"Voswinkel","year":"1999","journal-title":"Autoimmunity"},{"key":"10.1016\/j.humpath.2007.02.009_bib37","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1309\/6UGDU03VVD0L98LQ","article-title":"Characterization of incidentally identified minute clonal B-lymphocyte populations in peripheral blood and bone marrow","volume":"122","author":"Chen","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2007.02.009_bib38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1182\/blood.V100.2.635","article-title":"Monoclonal B lymphocytes with the characteristics of \u201cindolent\u201d chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts","volume":"100","author":"Rawstron","year":"2002","journal-title":"Blood"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707000974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707000974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T10:24:55Z","timestamp":1683887095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817707000974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0046817707000974"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2007.02.009","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}