{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:03Z","timestamp":1790856603268,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.humpath.2007.05.021","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T13:16:46Z","timestamp":1190985406000},"page":"102-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":120,"title":["Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis"],"prefix":"10.1016","volume":"39","author":[{"given":"Rosalyn","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ji","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith S.K.","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Csiszar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre A.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth B.","family":"Rand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E.","family":"Furth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca G.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2007.05.021_bib1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1083\/jcb.130.2.393","article-title":"Identification and characterization of a fibroblast marker: FSP1","volume":"130","author":"Strutz","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1016\/j.humpath.2007.05.021_bib2","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1038\/sj.onc.1208927","article-title":"TGF-beta and epithelial-to-mesenchymal transitions","volume":"24","author":"Zavadil","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2007.05.021_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","article-title":"Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention","volume":"15","author":"Liu","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2007.05.021_bib4","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/j.1600-6143.2005.00843.x","article-title":"Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis","volume":"5","author":"Vongwiwatana","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2007.05.021_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"Iwano","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2007.05.021_bib6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0002-9440(10)62351-6","article-title":"Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis","volume":"166","author":"Willis","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2007.05.021_bib7","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1016\/j.yexcr.2006.05.017","article-title":"Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: role of EGF receptor ligands","volume":"312","author":"Del Castillo","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.humpath.2007.05.021_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1128\/MCB.26.2.654-667.2006","article-title":"Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation","volume":"26","author":"Ju","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.humpath.2007.05.021_bib9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0168-8278(99)80292-X","article-title":"Effects of growth and differentiation factors on the epithelial-mesenchymal transition in cultured neonatal rat hepatocytes","volume":"31","author":"Pagan","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.humpath.2007.05.021_bib10","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.2353\/ajpath.2006.050747","article-title":"Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation","volume":"168","author":"Xia","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2007.05.021_bib11","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/hep.21624","article-title":"Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis","volume":"45","author":"Robertson","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.humpath.2007.05.021_bib12","doi-asserted-by":"crossref","first-page":"G575","DOI":"10.1152\/ajpgi.00102.2006","article-title":"Evidence for epithelial-mesenchymal transitions in adult liver cells","volume":"291","author":"Sicklick","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.humpath.2007.05.021_bib13","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0889-8553(03)00049-9","article-title":"Biliary atresia","volume":"32","author":"Haber","year":"2003","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.humpath.2007.05.021_bib14","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/hep.20547","article-title":"Outcome in adulthood of biliary atresia: a study of 63 patients who survived for over 20 years with their native liver","volume":"41","author":"Lykavieris","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.humpath.2007.05.021_bib15","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1158\/0008-5472.CAN-05-4609","article-title":"Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice","volume":"66","author":"Farazi","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2007.05.021_bib16","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2007.05.021_bib17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI29544","article-title":"A proximal activator of transcription in epithelial-mesenchymal transition","volume":"117","author":"Venkov","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2007.05.021_bib18","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1111\/j.1523-1755.2005.00358.x","article-title":"Antibodies against macrophages that overlap in specificity with fibroblasts","volume":"67","author":"Inoue","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.humpath.2007.05.021_bib19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00418-005-0788-z","article-title":"Characterization of renal interstitial fibroblast-specific protein 1\/S100A4-positive cells in healthy and inflamed rodent kidneys","volume":"123","author":"Le Hir","year":"2005","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.humpath.2007.05.021_bib20","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1074\/jbc.M106497200","article-title":"Xaa-Arg-Gly triplets in the collagen triple helix are dominant binding sites for the molecular chaperone HSP47","volume":"277","author":"Koide","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2007.05.021_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0065-1281(96)80019-5","article-title":"Ultrastructural sinusoidal changes in extrahepatic cholestasis. Light and electron microscopic immunohistochemical localization of collagen type III and type IV","volume":"98","author":"Gulubova","year":"1996","journal-title":"Acta Histochem"},{"key":"10.1016\/j.humpath.2007.05.021_bib22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s004180050126","article-title":"Heterogeneity of liver cells expressing procollagen types I and IV in vivo","volume":"107","author":"Herbst","year":"1997","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.humpath.2007.05.021_bib23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0022-3468(93)90343-J","article-title":"Increased deposition and serum level of type IV collagen in patients with extrahepatic biliary atresia","volume":"28","author":"Shirahase","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.humpath.2007.05.021_bib24","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1038\/sj.emboj.7600781","article-title":"A molecular role for lysyl oxidase\u2013like 2 enzyme in snail regulation and tumor progression","volume":"24","author":"Peinado","year":"2005","journal-title":"Embo J"},{"key":"10.1016\/j.humpath.2007.05.021_bib25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/labinvest.3700513","article-title":"Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries","volume":"87","author":"Beaussier","year":"2007","journal-title":"Lab Invest"},{"key":"10.1016\/j.humpath.2007.05.021_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/hep.21792","article-title":"TGF-beta and substrate stiffness regulate portal fibroblast activation in culture","author":"Li","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.humpath.2007.05.021_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1172\/JCI0216377","article-title":"Renal interstitial fibrosis: remembrance of things past?","volume":"110","author":"Herzlinger","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2007.05.021_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH657>3.0.CO;2-J","article-title":"In situ expression of fibrogenic growth factors and their receptors in biliary atresia: comparison between early and late stages","volume":"192","author":"Faiz Kabir Uddin Ahmed","year":"2000","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2007.05.021_bib29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0168-8278(99)80221-9","article-title":"Expression of collagens type I and IV, osteonectin and transforming growth factor beta-1 (TGFbeta1) in biliary atresia and paucity of intrahepatic bile ducts during infancy","volume":"31","author":"Lamireau","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.humpath.2007.05.021_bib30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jpedsurg.2004.01.030","article-title":"Identification of transforming growth factors actively transcribed during the progress of liver fibrosis in biliary atresia","volume":"39","author":"Lee","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.humpath.2007.05.021_bib31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0016-5085(95)90019-5","article-title":"Growth factor and procollagen type I gene expression in human liver disease","volume":"108","author":"Malizia","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humpath.2007.05.021_bib32","first-page":"1221","article-title":"Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease","volume":"139","author":"Milani","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2007.05.021_bib33","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)65595-2","article-title":"Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia","volume":"153","author":"Ramm","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2007.05.021_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-5793(04)00037-7","article-title":"Autocrine release of TGF-beta by portal fibroblasts regulates cell growth","volume":"559","author":"Wells","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.humpath.2007.05.021_bib35","doi-asserted-by":"crossref","first-page":"G845","DOI":"10.1152\/ajpgi.2000.279.5.G845","article-title":"Fibrogenesis. V. TGF-beta signaling pathways","volume":"279","author":"Wells","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.humpath.2007.05.021_bib36","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0092-8674(93)90368-Z","article-title":"Betaglycan presents ligand to the TGF beta signaling receptor","volume":"73","author":"Lopez-Casillas","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2007.05.021_bib37","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1128\/MCB.23.12.4371-4385.2003","article-title":"Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor\u2013deficient embryos","volume":"23","author":"Stenvers","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.humpath.2007.05.021_bib38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00428-005-0001-8","article-title":"Transforming growth factor-beta1 mediated up-regulation of lysyl oxidase in the kidneys of hereditary nephrotic mouse with chronic renal fibrosis","volume":"447","author":"Goto","year":"2005","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2007.05.021_bib39","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/(SICI)1097-4644(19970601)65:3<395::AID-JCB9>3.0.CO;2-N","article-title":"Transcriptional and post-transcriptional control of lysyl oxidase expression in vascular smooth muscle cells: effects of TGF-beta 1 and serum deprivation","volume":"65","author":"Gacheru","year":"1997","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.humpath.2007.05.021_bib40","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.4161\/cc.4.12.2224","article-title":"Switching on-off Snail: LOXL2 versus GSK3beta","volume":"4","author":"Peinado","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.humpath.2007.05.021_bib41","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.01907","article-title":"The Snail genes as inducers of cell movement and survival: implications in development and cancer","volume":"132","author":"Barrallo-Gimeno","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.humpath.2007.05.021_bib42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.matbio.2006.09.004","article-title":"Intracellular localization of the matrix enzyme lysyl oxidase in polarized epithelial cells","volume":"26","author":"Jansen","year":"2007","journal-title":"Matrix Biol"},{"key":"10.1016\/j.humpath.2007.05.021_bib43","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.humpath.2007.05.021_bib44","doi-asserted-by":"crossref","first-page":"C282","DOI":"10.1152\/ajpcell.00306.2005","article-title":"Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice","volume":"290","author":"Saika","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.humpath.2007.05.021_bib45","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1681\/ASN.V13196","article-title":"Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis","volume":"13","author":"Yang","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2007.05.021_bib46","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/5593","article-title":"Hepatocyte growth factor gene therapy of liver cirrhosis in rats","volume":"5","author":"Ueki","year":"1999","journal-title":"Nat Med"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707002985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707002985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:31:57Z","timestamp":1758645117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817707002985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0046817707002985"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2007.05.021","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2007.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}