{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:15:01Z","timestamp":1791152101025,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.humpath.2007.11.012","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T04:24:08Z","timestamp":1210739048000},"page":"1050-1058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":159,"title":["Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma\/chronic lymphocytic leukemia"],"prefix":"10.1016","volume":"39","author":[{"given":"Luc","family":"Xerri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Chetaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacer","family":"Seriari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Attias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Guillaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Arnoulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Olive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2007.11.012_bib1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.immunol.23.021704.115611","article-title":"The B7 family revisited","volume":"23","author":"Greenwald","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.humpath.2007.11.012_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/blood-2004-04-1596","article-title":"The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation","volume":"105","author":"Riley","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2007.11.012_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1615\/CritRevImmunol.v24.i4.10","article-title":"Negative regulation of T-cell function by PD1","volume":"24","author":"Zha","year":"2004","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.humpath.2007.11.012_bib4","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.4049\/jimmunol.175.11.7372","article-title":"Programmed death\u20131 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes","volume":"175","author":"Keir","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2007.11.012_bib5","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4049\/jimmunol.170.3.1257","article-title":"Blockade of programmed death\u20131 ligands on dendritic cells enhances T cell activation and cytokine production","volume":"170","author":"Brown","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2007.11.012_bib6","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1084\/jem.20051776","article-title":"Tissue expression of PD-L1 mediates peripheral T cell tolerance","volume":"203","author":"Keir","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.humpath.2007.11.012_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/08916930500124072","article-title":"PD1\/PD-L pathway and autoimmunity","volume":"38","author":"Okazaki","year":"2005","journal-title":"Autoimmunity"},{"key":"10.1016\/j.humpath.2007.11.012_bib8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"Barber","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2007.11.012_bib9","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1084\/jem.20061800","article-title":"Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade","volume":"203","author":"Freeman","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.humpath.2007.11.012_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4049\/jimmunol.173.1.68","article-title":"T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1\/Th2 effector cells that provide help for B cells","volume":"173","author":"Chtanova","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2007.11.012_bib11","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/01.pas.0000209855.28282.ce","article-title":"Programmed death-1 (PD-1) is a marker of germinal center\u2013associated T cells and angioimmunoblastic T-cell lymphoma","volume":"30","author":"Dorfman","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2007.11.012_bib12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-2478(02)00088-3","article-title":"Microanatomical localization of PD-1 in human tonsils","volume":"83","author":"Iwai","year":"2002","journal-title":"Immunol Lett"},{"key":"10.1016\/j.humpath.2007.11.012_bib13","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1182\/blood-2005-08-3376","article-title":"Intratumoral CD4+CD25+ regulatory T-cell\u2013mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma","volume":"107","author":"Yang","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2007.11.012_bib14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/eji.1830160605","article-title":"Anti-interleukin 2 receptor monoclonal antibodies. Respective role of epitope mapping and monoclonal antibody-receptor interactions in their antagonist effects on interleukin 2\u2013dependent T cell growth","volume":"16","author":"Olive","year":"1986","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humpath.2007.11.012_bib15","series-title":"Pathology and genetics of tumours of haematopoietic and lymphoid tissues","first-page":"189","year":"2001"},{"key":"10.1016\/j.humpath.2007.11.012_bib16","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/sj.onc.1209178","article-title":"Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas","volume":"25","author":"Ballester","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2007.11.012_bib17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<182::AID-PATH918>3.0.CO;2-I","article-title":"In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from human lymphomas","volume":"183","author":"Xerri","year":"1997","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2007.11.012_bib18","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1084\/jem.182.5.1265","article-title":"Fas ligation induces apoptosis of CD40 activated human B-lymphocytes","volume":"182","author":"Garrone","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.humpath.2007.11.012_bib19","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1182\/blood-2003-11-3890","article-title":"CD38 on B-cell chronic lymphocytic leukemia cells has higher expression in lymph nodes than in peripheral blood or bone marrow","volume":"103","author":"Jaksic","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2007.11.012_bib20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.humpath.2005.09.029","article-title":"The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"37","author":"Soma","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2007.11.012_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00262-004-0593-x","article-title":"Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy","volume":"54","author":"Blank","year":"2005","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.humpath.2007.11.012_bib22","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1158\/0008-5472.1089.65.3","article-title":"Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity","volume":"65","author":"Hirano","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2007.11.012_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/intimm\/dxh194","article-title":"PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells","volume":"17","author":"Iwai","year":"2005","journal-title":"Int Immunol"},{"key":"10.1016\/j.humpath.2007.11.012_bib24","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1002\/ijc.21795","article-title":"HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma","volume":"118","author":"Geng","year":"2006","journal-title":"Int J Cancer"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707006557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707006557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:32:03Z","timestamp":1758645123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817707006557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0046817707006557"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2007.11.012","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma\/chronic lymphocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2007.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}