{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:16:39Z","timestamp":1783721799877,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.humpath.2007.11.018","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T15:08:26Z","timestamp":1211382506000},"page":"1153-1161","source":"Crossref","is-referenced-by-count":79,"title":["Expression of cell cycle\u2013related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm"],"prefix":"10.1016","volume":"39","author":[{"given":"Yoshitsugu","family":"Nakanishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoh","family":"Zen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Itatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2007.11.018_bib1","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","article-title":"Cancer cell cycles","volume":"274","author":"Sherr","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.humpath.2007.11.018_bib2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1126\/science.2683075","article-title":"G1 events and regulation of cell proliferation","volume":"246","author":"Pardee","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.humpath.2007.11.018_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0092-8674(92)90360-O","article-title":"Identification and properties of an atypical catalytic subunit (p34PSK-J3\/cdk) for mammalian D type G1 cyclins","volume":"71","author":"Matsushima","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2007.11.018_bib4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/366704a0","article-title":"A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D\/CDK4","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2007.11.018_bib5","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/369574a0","article-title":"The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA","volume":"369","author":"Waga","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2007.11.018_bib6","first-page":"1169","article-title":"WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis","volume":"54","author":"el-Deiry","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2007.11.018_bib7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.271.5247.350","article-title":"dDPC4, a candidate tumor suppressor gene at human chromosome 18q21.1","volume":"271","author":"Hahn","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.humpath.2007.11.018_bib8","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/383832a0","article-title":"Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways","volume":"383","author":"Lagna","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2007.11.018_bib9","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s005340070002","article-title":"Precancerous lesions of intrahepatic cholangiocarcinoma","volume":"7","author":"Shimonishi","year":"2000","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.humpath.2007.11.018_bib10","first-page":"851","article-title":"Biliary papillary neoplasm of the liver","volume":"17","author":"Nakanuma","year":"2002","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00534-002-0729-3","article-title":"Anatomic and molecular pathology of intrahepatic cholangiocarcinoma","volume":"10","author":"Nakanuma","year":"2003","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.humpath.2007.11.018_bib12","series-title":"World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system","first-page":"173","article-title":"Intrahepatic cholangiocarcinoma","author":"Nakanuma","year":"2000"},{"key":"10.1016\/j.humpath.2007.11.018_bib13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1053\/jhep.2001.28199","article-title":"Intraductal papillary neoplasia of the liver associated with hepatolithiasis","volume":"34","author":"Chen","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.humpath.2007.11.018_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jhep.2005.09.025","volume":"44","author":"Zen","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.humpath.2007.11.018_bib15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1053\/hupa.2002.124030","article-title":"Increasing expression of gastrointestinal phenotypes and p53 along with histologic progression of intraductal papillary neoplasia of the liver","volume":"33","author":"Shimonishi","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1097-0029(19970915)38:6<552::AID-JEMT2>3.0.CO;2-H","article-title":"Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply","volume":"38","author":"Nakanuma","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.humpath.2007.11.018_bib17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/modpathol.3800788","article-title":"Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria","volume":"20","author":"Zen","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib18","series-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System","first-page":"237","article-title":"Intraductal papillary-mucinous neoplasms of the pancreas","author":"Longnecker","year":"2000"},{"key":"10.1016\/j.humpath.2007.11.018_bib19","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s00428-005-0039-7","article-title":"Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study","volume":"447","author":"Furukawa","year":"2005","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2007.11.018_bib20","first-page":"8830","article-title":"Overexpression of p21(WAF1\/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia","volume":"61","author":"Biankin","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2007.11.018_bib21","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/01.pas.0000131556.22382.3c","article-title":"Pancreatic intraepithelial neoplasia in association with intraductal papillary mucinous neoplasms of the pancreas: implications for disease progression and recurrence","volume":"28","author":"Biankin","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.humpath.2004.08.014","article-title":"Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis","volume":"35","author":"Ishikawa","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib23","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.21387","article-title":"Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas","volume":"44","author":"Zen","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.humpath.2007.11.018_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00000478-200403000-00005","article-title":"Pathologic features of mucin-producing bile duct tumors: two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms","volume":"28","author":"Shibahara","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib25","first-page":"2527","article-title":"DPC4 gene in various tumor types","volume":"56","author":"Schutte","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2007.11.018_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00019606-199704000-00003","article-title":"Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma","volume":"6","author":"Moskaluk","year":"1997","journal-title":"Diagn Mol Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0002-9440(10)64703-7","article-title":"Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation","volume":"156","author":"Wilentz","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib28","first-page":"2002","article-title":"Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression","volume":"60","author":"Wilentz","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2007.11.018_bib29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0002-9440(10)64589-0","article-title":"Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas","volume":"157","author":"Iacobuzio-Donahue","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib30","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/00000478-200107000-00014","article-title":"The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma","volume":"25","author":"Luttges","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2007.11.018_bib31","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gut.50.6.861","article-title":"Aberrant p16(INK4A) and DPC4\/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma","volume":"50","author":"Biankin","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2007.11.018_bib32","first-page":"1124","article-title":"Mutations of the DPC4\/Smad4 gene in biliary tract carcinoma","volume":"58","author":"Hahn","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2007.11.018_bib33","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/1097-0142(20010401)91:7<1332::AID-CNCR1136>3.0.CO;2-4","article-title":"Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts","volume":"91","author":"Argani","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2007.11.018_bib34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0046-8177(03)00337-X","article-title":"Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract","volume":"34","author":"Abraham","year":"2003","journal-title":"Hum Pathol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707006879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817707006879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T07:52:05Z","timestamp":1545983525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817707006879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0046817707006879"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2007.11.018","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}