{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:15:00Z","timestamp":1791152100598,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.humpath.2009.03.025","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T04:16:35Z","timestamp":1250741795000},"page":"1715-1722","source":"Crossref","is-referenced-by-count":130,"title":["Increased programmed death-1+ tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival"],"prefix":"10.1016","volume":"40","author":[{"given":"Simone","family":"Muenst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Hoeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Dirnhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2009.03.025_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000095558","article-title":"Pathobiology of classical Hodgkin lymphoma","volume":"73","author":"Tzankov","year":"2006","journal-title":"Pathobiology"},{"key":"10.1016\/j.humpath.2009.03.025_bib2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1080\/10428190500220654","article-title":"Tumor-infiltrating cells as a prognostic factor in Hodgkin's lymphoma: a quantitative tissue microarray study in a large retrospective cohort of 267 patients","volume":"46","author":"Alvaro-Naranjo","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2009.03.025_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF02893504","article-title":"Retrospective analysis of the prognostic role of tissue eosinophil and mast cells in Hodgkin's lymphoma","volume":"13","author":"Keresztes","year":"2007","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.humpath.2009.03.025_bib4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1365-2141.2002.03768.x","article-title":"Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma","volume":"119","author":"Molin","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2009.03.025_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3324\/haematol.11702","article-title":"Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma","volume":"93","author":"Tzankov","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2009.03.025_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/85330","article-title":"PD-L2 is a second ligand for PD-1 and inhibits T cell activation","volume":"2","author":"Latchman","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humpath.2009.03.025_bib7","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/01.pas.0000209855.28282.ce","article-title":"Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma","volume":"30","author":"Dorfman","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2009.03.025_bib8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ni1165","article-title":"Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4","volume":"6","author":"Probst","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humpath.2009.03.025_bib9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3324\/haematol.10864","article-title":"Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma","volume":"92","author":"Roncador","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2009.03.025_bib10","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.humpath.2007.11.012","article-title":"Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma\/chronic lymphocytic leukemia","volume":"39","author":"Xerri","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2009.03.025_bib11","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1182\/blood-2007-05-085159","article-title":"PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma","volume":"111","author":"Yamamoto","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.03.025_bib12","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/modpathol.3800276","article-title":"Rare expression of T-cell markers in classical Hodgkin's lymphoma","volume":"18","author":"Tzankov","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2009.03.025_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/PAI.0b013e3181845ef4","article-title":"Diagnostic utility of the B-cell lineage markers CD20, CD79a, PAX5, and CD19 in paraffin-embedded tissues from lymphoid neoplasms","volume":"17","author":"Adams","year":"2009","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.humpath.2009.03.025_bib14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/modpathol.2008.207","article-title":"Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas","volume":"22","author":"Meier","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2009.03.025_bib15","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1182\/blood-2006-05-024109","article-title":"Hodgkin lymphoma and immunodeficiency in persons with HIV\/AIDS","volume":"108","author":"Biggar","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.03.025_bib16","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1182\/blood.V89.4.1376","article-title":"Activated cytotoxic T cells as prognostic marker in Hodgkin's disease","volume":"89","author":"Oudejans","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.03.025_bib17","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1172\/JCI200422325","article-title":"Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B-cell responses","volume":"114","author":"Lim","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2009.03.025_bib18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1182\/blood-2006-02-002774","article-title":"Regulatory T cells in cancer","volume":"108","author":"Beyer","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.03.025_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0952-7915(03)00107-9","article-title":"Granzyme B: pro-apoptotic, antiviral and antitumor functions","volume":"15","author":"Trapani","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.humpath.2009.03.025_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/scbi.2000.0327","article-title":"Interaction between host T cells and Reed-Sternberg cells in Hodgkin lymphomas","volume":"10","author":"Poppema","year":"2000","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.humpath.2009.03.025_bib21","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.4049\/jimmunol.166.6.3789","article-title":"IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo","volume":"166","author":"Hara","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2009.03.025_bib22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10875-008-9254-8","article-title":"Peripherally induced Treg: mode, stability, and role in specific tolerance","volume":"28","author":"Apostolou","year":"2008","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.humpath.2009.03.025_bib23","doi-asserted-by":"crossref","first-page":"834","DOI":"10.4049\/jimmunol.172.2.834","article-title":"TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice","volume":"172","author":"Nakamura","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2009.03.025_bib24","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/01.tp.0000256293.90270.e8","article-title":"Involvement of the programmed death-1\/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-cell activity to suppress alloimmune responses","volume":"83","author":"Kitazawa","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.humpath.2009.03.025_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.med.56.082103.104549","article-title":"Effective cancer therapy through immunomodulation","volume":"57","author":"Waldmann","year":"2006","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.humpath.2009.03.025_bib26","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1084\/jem.20080809","article-title":"Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis","volume":"205","author":"Brune","year":"2008","journal-title":"J Exp Med"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817709001725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817709001725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T11:35:14Z","timestamp":1590060914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817709001725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0046817709001725"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2009.03.025","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}