{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:18:04Z","timestamp":1791249484442,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.humpath.2009.07.022","type":"journal-article","created":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T12:26:46Z","timestamp":1260361606000},"page":"271-280","source":"Crossref","is-referenced-by-count":38,"title":["CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas"],"prefix":"10.1016","volume":"41","author":[{"given":"Robert F.","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Tibshirani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June H.","family":"Myklebust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinmoy","family":"Sanyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dita","family":"Gratzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Shun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasodha","family":"Natkunam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2009.07.022_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri1548","article-title":"The tetraspanin web modulates immune-signaling complexes","volume":"5","author":"Levy","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humpath.2009.07.022_bib2","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.4049\/jimmunol.171.8.4062","article-title":"The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment","volume":"171","author":"Shoham","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2009.07.022_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1074-7613(00)80418-5","article-title":"The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity","volume":"6","author":"Tedder","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.humpath.2009.07.022_bib4","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.282.5390.938","article-title":"Binding of hepatitis C virus to CD81","volume":"282","author":"Pileri","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.humpath.2009.07.022_bib5","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1080\/1042819031000076972","article-title":"Hepatitis C virus (HCV) and lymphomagenesis","volume":"44","author":"Weng","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2009.07.022_bib6","doi-asserted-by":"crossref","first-page":"18544","DOI":"10.1073\/pnas.0509402102","article-title":"Activation of na\u00efve B lymphocytes via CD81, a pathogenic mechanism for hepatitis C virus\u2013associated B lymphocyte disorders","volume":"102","author":"Rosa","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.humpath.2009.07.022_bib7","doi-asserted-by":"crossref","first-page":"8079","DOI":"10.1128\/JVI.79.13.8079-8089.2005","article-title":"Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells","volume":"79","author":"Machida","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.humpath.2009.07.022_bib8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4049\/jimmunol.181.1.174","article-title":"Coligation of the hepatitis C virus receptor CD81 with CD28 primes na\u00efve T lymphocytes to acquire type 2 effector function","volume":"181","author":"Serra","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2009.07.022_bib9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2009.07.022_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nm0102-68","article-title":"Diffuse large B cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning","volume":"8","author":"Shipp","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.humpath.2009.07.022_bib11","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1182\/blood-2004-07-2947","article-title":"Molecular profiling of diffuse large B cell lymphoma identifies robust subtypes including one characterized by host inflammatory response","volume":"105","author":"Monti","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.07.022_bib12","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa012914","article-title":"Lymphoma\/Leukemia Molecular Profiling Project. The use of molecular profiling to predict survival after chemotherapy for diffuse large B cell lymphoma","volume":"346","author":"Rosenwald","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2009.07.022_bib13","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJMoa032520","article-title":"Prediction of survival in diffuse large-B cell lymphoma based on the expression of six genes","volume":"350","author":"Lossos","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2009.07.022_bib14","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1182\/blood-2008-02-136374","article-title":"Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP","volume":"111","author":"Malumbres","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.07.022_bib15","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1182\/blood-2006-08-039024","article-title":"The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B cell lymphomas","volume":"109","author":"Natkunam","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.07.022_bib16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1200\/JCO.2007.13.0690","article-title":"LMO2 protein expression predicts survival in patients with diffuse large B cell lymphoma treated with anthracycline-based chemotherapy with and without rituximab","volume":"26","author":"Natkunam","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2009.07.022_bib17","doi-asserted-by":"crossref","first-page":"E108","DOI":"10.1371\/journal.pbio.0020108","article-title":"Semi-supervised methods to predict patient survival from gene expression data","volume":"2","author":"Bair","year":"2004","journal-title":"PLoS Biol"},{"key":"10.1016\/j.humpath.2009.07.022_bib18","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa055351","article-title":"Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling","volume":"354","author":"Hummel","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2009.07.022_bib19","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1200\/JCO.2005.02.4786","article-title":"Prognostic biomarkers in diffuse large B cell lymphoma","volume":"24","author":"Lossos","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2009.07.022_bib20","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissue","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.humpath.2009.07.022_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/1097-0215(20000720)89:4<313::AID-IJC1>3.0.CO;2-D","article-title":"Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B cell non-Hodgkin's lymphoma","volume":"89","author":"Stokke","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2009.07.022_bib22","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1182\/blood-2004-08-3112","article-title":"Expression of the human germinal center\u2013associated lymphoma (HGAL) protein, a new marker of germinal center B cell derivation","volume":"105","author":"Natkunam","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.07.022_bib23","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH665>3.0.CO;2-O","article-title":"Double immunofluorescence labelling of routinely processed paraffin sections","volume":"191","author":"Mason","year":"2000","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2009.07.022_bib24","doi-asserted-by":"crossref","first-page":"D871","DOI":"10.1093\/nar\/gkm861","article-title":"The Stanford tissue microarray database","volume":"36","author":"Marinelli","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.humpath.2009.07.022_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2009.07.022_bib26","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/modpathol.3880373","article-title":"Analysis of MUM1\/IRF4 protein expression using tissue microarrays and immunohistochemistry","volume":"14","author":"Natkunam","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2009.07.022_bib27","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.4049\/jimmunol.169.12.6691","article-title":"Cutting edge: dynamic redistribution of tetraspanin CD81 at the central zone of the immune synapse in both T lymphocytes and APC","volume":"15","author":"Mittelbrunn","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2009.07.022_bib28","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1136\/jcp.2007.051870","article-title":"Hepatitis C virus and lymphoma","volume":"60","author":"Viswanatha","year":"2007","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2009.07.022_bib29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJMoa011795","article-title":"CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large B cell lymphoma","volume":"346","author":"Coiffier","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2009.07.022_bib30","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1200\/JCO.2005.05.1003","article-title":"Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B cell lymphoma","volume":"24","author":"Habermann","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2009.07.022_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1470-2045(06)70664-7","article-title":"CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large B cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) group","volume":"7","author":"Pfreundschuh","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.humpath.2009.07.022_bib32","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1200\/JCO.2005.09.137","article-title":"Introduction of combined CHOP plus rituximab therapy dramatically improved outcome of diffuse large B cell lymphoma in British Columbia","volume":"23","author":"Sehn","year":"2005","journal-title":"J Clin Oncol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817709002858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817709002858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T18:59:04Z","timestamp":1544813944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817709002858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0046817709002858"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2009.07.022","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}