{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:31:08Z","timestamp":1785259868380,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.humpath.2010.04.005","type":"journal-article","created":{"date-parts":[[2010,7,25]],"date-time":"2010-07-25T09:14:45Z","timestamp":1280049285000},"page":"1486-1494","source":"Crossref","is-referenced-by-count":30,"title":["The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms"],"prefix":"10.1016","volume":"41","author":[{"given":"David M.","family":"Dorfman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Hornick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliakbar","family":"Shahsafaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon J.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2010.04.005_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-065X.2009.00772.x","article-title":"The costimulatory role of TIM molecules","volume":"229","author":"Rodriguez-Manzanet","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1016\/j.humpath.2010.04.005_bib2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2007.11.011","article-title":"TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells","volume":"27","author":"Kobayashi","year":"2007","journal-title":"Immunity"},{"issue":"18","key":"10.1016\/j.humpath.2010.04.005_bib3","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1128\/JVI.00639-09","article-title":"Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+T cells","volume":"83","author":"Golden-Mason","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.humpath.2010.04.005_bib4","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1182\/blood-2008-10-185884","article-title":"Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation","volume":"113","author":"Nakayama","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2010.04.005_bib5","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.4049\/jimmunol.0903059","article-title":"TIM-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells","volume":"184","author":"DeKruyff","year":"2010","journal-title":"J Immunol"},{"issue":"5853","key":"10.1016\/j.humpath.2010.04.005_bib6","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.1148536","article-title":"Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells","volume":"318","author":"Anderson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.humpath.2010.04.005_bib7","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.humpath.2010.04.005_bib8","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0002-9440(10)64287-3","article-title":"Loss of expression of the WNT\/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor (TCF-1) in a subset of peripheral T cell lymphomas","volume":"162","author":"Dorfman","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2010.04.005_bib9","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/01.pas.0000209855.28282.ce","article-title":"Programmed death-1 (PD-1) is a marker of germinal center-associated T cell and angioimmunoblastic T-cell lymphoma","volume":"30","author":"Dorfman","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2010.04.005_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/pbc.20246","article-title":"Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses","volume":"45","author":"Weitzman","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.humpath.2010.04.005_bib11","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1056\/NEJMcpc0804623","article-title":"Case records of the Massachusetts General Hospital (Case 25-2008: a 43-year-old man with fatigue and lesion sin the pituitary and cerebellum","volume":"359","author":"Mills","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2010.04.005_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4049\/jimmunol.177.1.280","article-title":"Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts","volume":"177","author":"Munoz-Fernandez","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2010.04.005_bib13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/PAS.0b013e31815b212b","article-title":"Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders","volume":"32","author":"Lau","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2010.04.005_bib14","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/01.pas.0000131541.95394.23","article-title":"Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy","volume":"28","author":"Hornick","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2010.04.005_bib15","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1309\/7P8U659JBJCV6EEU","article-title":"Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors","volume":"128","author":"Yu","year":"2007","journal-title":"Am J Clin Pathol"},{"issue":"9","key":"10.1016\/j.humpath.2010.04.005_bib16","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1002\/eji.200939274","article-title":"TIM-3 is expressed on activated human CD4+T cells and regulates TH1 and TH17 cytokines","volume":"39","author":"Hastings","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humpath.2010.04.005_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/83210","article-title":"Bipotential B-macrophage progenitors are present in adult bone marrow","volume":"2","author":"Montecino-Rodriguez","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humpath.2010.04.005_bib18","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1182\/blood-2004-07-2839","article-title":"Identification of a human B-cell\/myeloid common progenitor by the absence of CXCR4","volume":"105","author":"Hou","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2010.04.005_bib19","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1182\/blood-2007-11-124792","article-title":"Clonally related follicular lymphomas and histiocytic\/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone","volume":"111","author":"Feldman","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2010.04.005_bib20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S1470-2045(04)01428-7","article-title":"Histiocytic sarcoma after acute lymphoblastic leukemia: a common clonal origin","volume":"5","author":"Feldman","year":"2004","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.humpath.2010.04.005_bib21","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0145-2126(02)00009-7","article-title":"Identical gene rearrangement of immunoglobulin heavy chain gene in neoplastic Langerhans cells and B-lymphocytes: evidence for a common precursor","volume":"26","author":"Magni","year":"2002","journal-title":"Leuk Res"},{"key":"10.1016\/j.humpath.2010.04.005_bib22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(04)00419-2","article-title":"Stepwise reprogramming of B cell into macrophages","volume":"117","author":"Xie","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2010.04.005_bib23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature06159","article-title":"Conversion of mature B cells into T cell by dedifferentiation to uncommitted progenitors","volume":"449","author":"Colbaleda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2010.04.005_bib24","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/sj.leu.2402602","article-title":"Interferon-alpha induces dendritic cell differentiation of CML mononuclear cells in vitro and in vivo","volume":"16","author":"Paquette","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2010.04.005_bib25","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0002-9440(10)63882-5","article-title":"Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms","volume":"162","author":"Marafioti","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2010.04.005_bib26","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1309\/AQQ2DVM75DVY0PWP","article-title":"T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disorders","volume":"122","author":"Dorfman","year":"2004","journal-title":"Am J Clin Pathol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817710001218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817710001218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T06:28:13Z","timestamp":1544336893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817710001218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0046817710001218"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2010.04.005","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}