{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:10:33Z","timestamp":1761743433906},"reference-count":33,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.humpath.2010.04.017","type":"journal-article","created":{"date-parts":[[2010,11,14]],"date-time":"2010-11-14T04:16:53Z","timestamp":1289708213000},"page":"1735-1741","source":"Crossref","is-referenced-by-count":18,"title":["The epidermal growth factor receptor pathway in relation to pelvic lymph node metastasis and survival in early-stage cervical cancer"],"prefix":"10.1016","volume":"41","author":[{"given":"Jasper J.H.","family":"Eijsink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maartje G.","family":"Noordhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaske A.","family":"ten Hoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Kok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Hollema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geertruida H.","family":"de Bock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans W.","family":"Nijman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Schuuring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Bea A.","family":"Wisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ate G.J.","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2010.04.017_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0090-8258(89)90598-2","article-title":"Determinants of increased risk for recurrence in patients undergoing radical hysterectomy for stage IB and IIA carcinoma of the cervix","volume":"33","author":"Fuller","year":"1989","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.humpath.2010.04.017_bib2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/1097-0142(19850715)56:2<262::AID-CNCR2820560210>3.0.CO;2-A","article-title":"Combined radiation therapy and extra-fascial hysterectomy in the treatment of stage IB barrel-shaped cervical cancer","volume":"56","author":"Gallion","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2010.04.017_bib3","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1002\/1097-0142(19841215)54:12<3072::AID-CNCR2820541244>3.0.CO;2-E","article-title":"Stage Ib, IIa, and IIb cervix cancer, postsurgical staging, and prognosis","volume":"54","author":"Matsuyama","year":"1984","journal-title":"Cancer"},{"issue":"10 Suppl","key":"10.1016\/j.humpath.2010.04.017_bib4","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1002\/1097-0142(19951115)76:10+<1978::AID-CNCR2820761313>3.0.CO;2-K","article-title":"Prognostic factors of early stage cervical cancer treated by radical hysterectomy","volume":"76","author":"Sevin","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2010.04.017_bib5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ygyno.2003.11.020","article-title":"Is lymph vascular space involvement an independent prognostic factor in early cervical cancer?","volume":"92","author":"Creasman","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.humpath.2010.04.017_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10147-007-0661-2","article-title":"Up-to-date management of lymph node metastasis and the role of tailored lymphadenectomy in cervical cancer","volume":"12","author":"Sakuragi","year":"2007","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.humpath.2010.04.017_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.humpath.2010.04.017_bib8","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/carcin\/bgm052","article-title":"PTEN, more than the AKT pathway","volume":"28","author":"Blanco-Aparicio","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.humpath.2010.04.017_bib9","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1200\/JCO.2004.02.141","article-title":"The biology and clinical relevance of the PTEN tumor suppressor pathway","volume":"22","author":"Sansal","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2010.04.017_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jcp.46.2.149","article-title":"Prognostic value of epidermal growth factor receptor expression in cervical carcinoma","volume":"46","author":"Hale","year":"1993","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2010.04.017_bib11","first-page":"577","article-title":"Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis","volume":"5","author":"Kersemaekers","year":"1999","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2010.04.017_bib12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/(SICI)1097-0142(19960801)78:3<433::AID-CNCR9>3.0.CO;2-K","article-title":"Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study","volume":"78","author":"Kristensen","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2010.04.017_bib13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jso.20493","article-title":"Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma","volume":"93","author":"Lee","year":"2006","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.humpath.2010.04.017_bib14","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1136\/jcp.2005.036038","article-title":"Loss of MSH2 protein expression is a risk factor in early stage cervical cancer","volume":"60","author":"Nijhuis","year":"2007","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2010.04.017_bib15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.bjc.6604471","article-title":"The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer","volume":"99","author":"de Graeff","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2010.04.017_bib16","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ygyno.2004.03.013","article-title":"Epigenetic and genetic alternation of PTEN in cervical neoplasm","volume":"93","author":"Cheung","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.humpath.2010.04.017_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0014-4827(03)00002-8","article-title":"Trafficking of the ErbB receptors and its influence on signaling","volume":"284","author":"Wiley","year":"2003","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.humpath.2010.04.017_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/PGP.0b013e3181817b2a","article-title":"Validation of tissue microarray technology in vulvar cancer","volume":"28","author":"Fons","year":"2009","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2010.04.017_bib19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ng.356","article-title":"Braf(V600E) cooperates with Pten loss to induce metastatic melanoma","volume":"41","author":"Dankort","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2010.04.017_bib20","first-page":"856","article-title":"Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival","author":"Sawai","year":"2008","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.humpath.2010.04.017_bib21","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.273.22.13375","article-title":"The tumor suppressor, PTEN\/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate","volume":"273","author":"Maehama","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2010.04.017_bib22","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/ijc.21461","article-title":"Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation","volume":"118","author":"Bertelsen","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2010.04.017_bib23","first-page":"57","article-title":"Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy","volume":"16","author":"Faried","year":"2006","journal-title":"Oncol Rep"},{"key":"10.1016\/j.humpath.2010.04.017_bib24","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1038\/sj.bjc.6603180","article-title":"Increased expression of pAKT is associated with radiation resistance in cervical cancer","volume":"94","author":"Kim","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2010.04.017_bib25","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/436792a","article-title":"Colorectal cancer: mutations in a signalling pathway","volume":"436","author":"Parsons","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2010.04.017_bib26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-kinase AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.humpath.2010.04.017_bib27","article-title":"An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation","author":"Talotta","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2010.04.017_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1158\/0008-5472.CAN-07-2488","article-title":"MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN","volume":"68","author":"Yang","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2010.04.017_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/gyno.1999.5659","article-title":"Mutation analysis of the putative tumor suppressor gene PTEN\/MMAC1 in cervical cancer","volume":"76","author":"Su","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.humpath.2010.04.017_bib30","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1158\/1078-0432.CCR-07-1231","article-title":"Altered MicroRNA expression in cervical carcinomas","volume":"14","author":"Lee","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2010.04.017_bib31","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1158\/0008-5472.CAN-06-0561","article-title":"Patterns of known and novel small RNAs in human cervical cancer","volume":"67","author":"Lui","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2010.04.017_bib32","doi-asserted-by":"crossref","first-page":"10314","DOI":"10.1073\/pnas.171076798","article-title":"Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP\/mTOR","volume":"98","author":"Neshat","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2010.04.017_bib33","doi-asserted-by":"crossref","first-page":"10320","DOI":"10.1073\/pnas.171060098","article-title":"An inhibitor of mTOR reduces neoplasia and normalizes p70\/S6 kinase activity in Pten+\/\u2212 mice","volume":"98","author":"Podsypanina","year":"2001","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817710001905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817710001905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T04:25:22Z","timestamp":1559795122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817710001905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0046817710001905"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2010.04.017","relation":{},"ISSN":["0046-8177"],"issn-type":[{"type":"print","value":"0046-8177"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}