{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:47:25Z","timestamp":1791298045799,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.humpath.2010.05.016","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T04:35:24Z","timestamp":1288067724000},"page":"75-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells"],"prefix":"10.1016","volume":"42","author":[{"given":"Arnaud","family":"Berthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Jim\u00e9nez-S\u00e1inz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Rogl\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Ripoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cervera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2010.05.016_bb0005","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/01.wco.0000186841.43505.e6","article-title":"How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease","volume":"18","author":"Cookson","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.humpath.2010.05.016_bb0010","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molmed.2006.09.007","article-title":"Understanding the molecular causes of Parkinson's disease","volume":"12","author":"Wood-Kaczmar","year":"2006","journal-title":"Trends Mol Med"},{"issue":"Suppl 3","key":"10.1016\/j.humpath.2010.05.016_bb0015","doi-asserted-by":"crossref","first-page":"S233","DOI":"10.1016\/S1353-8020(08)70008-7","article-title":"Genetics of parkinsonism","volume":"13","author":"Bonifati","year":"2007","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.humpath.2010.05.016_bb0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3835(03)00443-9","article-title":"BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential","volume":"201","author":"Nakajima","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2010.05.016_bb0025","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/sj.onc.1204608","article-title":"Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway","volume":"20","author":"Unoki","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2010.05.016_bb0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1471-4159.2008.05249.x","article-title":"Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)","volume":"105","author":"Mills","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.humpath.2010.05.016_bb0035","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson's disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.humpath.2010.05.016_bb0040","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1093\/hmg\/ddi377","article-title":"Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism","volume":"14","author":"Silvestri","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.humpath.2010.05.016_bb0045","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.1073\/pnas.0802814105","article-title":"The kinase domain of mitochondrial PINK1 faces the cytoplasm","volume":"105","author":"Zhou","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2010.05.016_bb0050","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1073\/pnas.0705363105","article-title":"Cytoplasmic PINK1 activity protects neurons from dopaminergic neurotoxin MPTP","volume":"105","author":"Haque","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2010.05.016_bb0055","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/brain\/awl114","article-title":"PINK1 protein in normal human brain and Parkinson's disease","volume":"129","author":"Gandhi","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.humpath.2010.05.016_bb0060","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0959-8049(00)00366-X","article-title":"Heterogeneous lack of expression of the tumor suppressor PTEN protein in human neoplastic tissues","volume":"37","author":"Torres","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.humpath.2010.05.016_bb0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ijc.10269","article-title":"C-myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells","volume":"99","author":"Venditti","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2010.05.016_bb0070","doi-asserted-by":"crossref","first-page":"e4756","DOI":"10.1371\/journal.pone.0004756","article-title":"Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells","volume":"4","author":"Gegg","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2010.05.016_bb0075","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1021\/bi8019178","article-title":"PINK1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking","volume":"48","author":"Weihofen","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.humpath.2010.05.016_bb0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2007.09.056","article-title":"Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease","volume":"1184","author":"Blackinton","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.humpath.2010.05.016_bb0085","series-title":"An atlas of ultrastructure","first-page":"84","author":"Rhodin","year":"1963"},{"key":"10.1016\/j.humpath.2010.05.016_bb0090","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1002\/pmic.200400952","article-title":"Lipid raft proteome reveals ATP synthase complex in the cell surface","volume":"4","author":"Bae","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.humpath.2010.05.016_bb0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mito.2006.10.001","article-title":"The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: an immunocytochemical study","volume":"6","author":"Yonally","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1016\/j.humpath.2010.05.016_bb0100","doi-asserted-by":"crossref","first-page":"34025","DOI":"10.1074\/jbc.M505143200","article-title":"Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations","volume":"280","author":"Petit","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2010.05.016_bb0105","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1073\/pnas.0901104106","article-title":"FOXO3a-dependent regulation of PINK1 (Park6) mediates survival signaling in response to cytokine deprivation","volume":"106","author":"Mei","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2010.05.016_bb0110","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.nbd.2007.07.010","article-title":"PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c","volume":"28","author":"Wang","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.humpath.2010.05.016_bb0115","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1471-4159.2008.05398.x","article-title":"Characterization of PINK1 processing, stability, and subcellular localization","volume":"106","author":"Lin","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.humpath.2010.05.016_bb0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1242\/jcs.031682","article-title":"Control of mitochondrial apoptosis by the Bcl-2 family","volume":"122","author":"Brunelle","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.humpath.2010.05.016_bb0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcancer.2008.12.001","article-title":"Mitochondrial dynamics and cancer","volume":"19","author":"Grandemange","year":"2009","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.humpath.2010.05.016_bb0130","doi-asserted-by":"crossref","first-page":"e5701","DOI":"10.1371\/journal.pone.0005701","article-title":"Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1","volume":"4","author":"Sandebring","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2010.05.016_bb0135","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1073\/pnas.0711845105","article-title":"PINK1 regulates mitochondrial dynamics through interaction with the fission\/fusion machinery","volume":"105","author":"Yang","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2010.05.016_bb0140","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2007.08.028","article-title":"Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network","volume":"131","author":"Kang","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2010.05.016_bb0145","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1371\/journal.pbio.0050172","article-title":"PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1","volume":"5","author":"Pridgeon","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1016\/j.humpath.2010.05.016_bb0150","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/hmg\/ddm334","article-title":"PINK1 Parkinson mutations, the Cdc37\/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1","volume":"17","author":"Weihofen","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.humpath.2010.05.016_bb0155","first-page":"2656","article-title":"Antiproliferative and antiapoptotic effects of crel may occur within the same cells via the up-regulation of manganese superoxide dismutase","volume":"61","author":"Bernard","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2010.05.016_bb0160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/B:MCBI.0000049134.69131.89","article-title":"Telser. Role of oxygen radicals in DNA damage and cancer incidence","volume":"266","author":"Valko","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.humpath.2010.05.016_bb0165","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.dnarep.2008.03.005","article-title":"The role of the DNA damage response in neuronal development, organization and maintenance","volume":"7","author":"Barzilai","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.humpath.2010.05.016_bb0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.mam.2010.02.008","article-title":"The causes of cancer revisited: \u201cMitochondrial malignancy\u201d and ROS-induced oncogenic transformation\u2014why mitochondria are targets for cancer therapy","volume":"31","author":"Ralph","year":"2010","journal-title":"Mol Aspects Med"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817710002261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817710002261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:32:46Z","timestamp":1758645166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817710002261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0046817710002261"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2010.05.016","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2010.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}