{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:47:22Z","timestamp":1759333642217,"version":"3.38.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.humpath.2011.05.008","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T01:23:59Z","timestamp":1313544239000},"page":"381-389","source":"Crossref","is-referenced-by-count":23,"title":["Neuropilin-2: a novel biomarker for malignant melanoma?"],"prefix":"10.1016","volume":"43","author":[{"given":"Erica C.","family":"Rushing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan J.","family":"Stine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Eller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Naif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarika","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Westra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim A.","family":"Jungbluth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus J.","family":"Busam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Mahalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhoda M.","family":"Alani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2011.05.008_bb0005","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1600-0749.2006.00356.x","article-title":"Molecular markers of circulating melanoma cells","volume":"20","author":"Medic","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.humpath.2011.05.008_bb0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1053\/j.seminoncol.2007.09.009","article-title":"Angiogenesis in melanoma","volume":"34","author":"Mahabeleshwar","year":"2007","journal-title":"Semin Oncol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/jcp.2005.028431","article-title":"Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study","volume":"59","author":"Massi","year":"2006","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0020","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/modpathol.3800410","article-title":"Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes","volume":"18","author":"Dadras","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0025","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.0303-6987.2004.00249.x","article-title":"Lymphatic vessel density is significantly increased in melanoma","volume":"31","author":"Giorgadze","year":"2004","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0030","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.0022-202X.2004.23460.x","article-title":"Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling","volume":"123","author":"Graells","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0035","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0002-9440(10)64328-3","article-title":"Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival","volume":"162","author":"Dadras","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0040","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/path.2182","article-title":"Neuropilins in physiological and pathological angiogenesis","volume":"212","author":"Staton","year":"2007","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0045","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.yexcr.2005.11.024","article-title":"Neuropilins in neoplasms: expression, regulation, and function","volume":"312","author":"Bielenberg","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.humpath.2011.05.008_bb0050","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1182\/blood-2005-11-4447","article-title":"Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration","volume":"108","author":"Favier","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2011.05.008_bb0055","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2008.01.029","article-title":"Blocking neuropilin-2 function inhibits tumor cell metastasis","volume":"13","author":"Caunt","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.humpath.2011.05.008_bb0060","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10555-007-9097-4","article-title":"Targeting endothelial and tumor cells with semaphorins","volume":"26","author":"Bielenberg","year":"2007","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.humpath.2011.05.008_bb0065","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00268-004-7818-1","article-title":"Roles of neuropilins in neuronal development, angiogenesis, and cancers","volume":"29","author":"Chen","year":"2005","journal-title":"World J Surg"},{"key":"10.1016\/j.humpath.2011.05.008_bb0070","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1158\/1535-7163.MCT-05-0538","article-title":"The role of neuropilins in cancer","volume":"5","author":"Ellis","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.humpath.2011.05.008_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2004.12.047","article-title":"The neuropilins and their role in tumorigenesis and tumor progression","volume":"231","author":"Guttmann-Raviv","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2011.05.008_bb0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-4615-0119-0_3","article-title":"The role of neuropilin in vascular and tumor biology","volume":"515","author":"Klagsbrun","year":"2002","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0085","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0002-9440(10)63679-6","article-title":"Gene discovery in bladder cancer progression using cDNA microarrays","volume":"163","author":"Sanchez-Carbayo","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0090","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1172\/JCI21378","article-title":"Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype","volume":"114","author":"Bielenberg","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2011.05.008_bb0095","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/pros.20095","article-title":"Trefoil factor 3 overexpression in prostatic carcinoma: prognostic importance using tissue microarrays","volume":"61","author":"Faith","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.humpath.2011.05.008_bb0100","first-page":"856","article-title":"FrIDA: An open source framework for image dataset analysis","volume":"132","author":"Cornish","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2011.05.008_bb0105","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"A language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J Comput Graph Stat"},{"key":"10.1016\/j.humpath.2011.05.008_bb0110","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1242\/dev.129.20.4797","article-title":"Abnormal lymphatic vessel development in neuropilin 2 mutant mice","volume":"129","author":"Yuan","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.humpath.2011.05.008_bb0115","doi-asserted-by":"crossref","unstructured":"Dadras SS, Detmar M. Angiogenesis and lymphangiogenesis of skin cancers. Hematol Oncol Clin North Am 2004; 18:1059-70.","DOI":"10.1016\/j.hoc.2004.06.009"},{"key":"10.1016\/j.humpath.2011.05.008_bb0120","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/cncr.10936","article-title":"Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma","volume":"95","author":"Kawakami","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2011.05.008_bb0125","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/path.1367","article-title":"Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines","volume":"200","author":"Lantuejoul","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0130","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1097\/01.pas.0000141391.91677.a4","article-title":"Cutaneous desmoplastic melanoma: reappraisal of morphologic heterogeneity and prognostic factors","volume":"28","author":"Busam","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/path.1179","article-title":"Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours","volume":"198","author":"Cohen","year":"2002","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2011.05.008_bb0140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0925-4773(02)00305-2","article-title":"Ontogeny of semaphorins 3A and 3F and their receptors neuropilins 1 and 2 in the kidney","volume":"2","author":"Villegas","year":"2002","journal-title":"Gene Expr Patterns"},{"key":"10.1016\/j.humpath.2011.05.008_bb0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2119\/2006-00024.Man","article-title":"Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis","volume":"12","author":"Man","year":"2006","journal-title":"Mol Med"},{"key":"10.1016\/j.humpath.2011.05.008_bb0150","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/ijc.25571","article-title":"Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay","volume":"128","author":"Rappu","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2011.05.008_bb0155","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1158\/0008-5472.CAN-10-1875","article-title":"Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stroma interaction","volume":"71","author":"Stine","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2011.05.008_bb0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/geno.2000.6381","article-title":"Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms","volume":"70","author":"Rossignol","year":"2000","journal-title":"Genomics"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817711002176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817711002176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T20:51:24Z","timestamp":1741467084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817711002176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0046817711002176"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2011.05.008","relation":{},"ISSN":["0046-8177"],"issn-type":[{"type":"print","value":"0046-8177"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}