{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:05:48Z","timestamp":1784894748149,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.humpath.2011.06.013","type":"journal-article","created":{"date-parts":[[2011,9,18]],"date-time":"2011-09-18T11:55:32Z","timestamp":1316346932000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["A clinical, pathologic, and molecular study of p53 and murine double minute 2 in penile carcinogenesis and its relation to prognosis"],"prefix":"10.1016","volume":"43","author":[{"given":"Rafael Malagoli","family":"Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianna Alves","family":"Ign\u00e1cio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Jord\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirce Maria","family":"Carraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Lisboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia C\u00e2ndido","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Werneck","family":"da Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio","family":"Cubilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Cardoso","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2011.06.013_bb0005","doi-asserted-by":"crossref","first-page":"243","DOI":"10.32635\/2176-9745.RBC.2005v51n3.1952","article-title":"Carcinoma epiderm\u00f3ide do p\u00eanis: considera\u00e7\u00f5es epidemiol\u00f3gicas, histopatol\u00f3gicas, influ\u00eancia viral e tratamento cir\u00fargico","volume":"51","author":"Peclat de Paula","year":"2005","journal-title":"Rev Bras Cancerol"},{"key":"10.1016\/j.humpath.2011.06.013_bb0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/00365590050509913","article-title":"Etiology of squamous cell carcinoma of the penis","volume":"205","author":"Dillner","year":"2000","journal-title":"Scand J Urol Nephrol Suppl"},{"key":"10.1016\/j.humpath.2011.06.013_bb0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1200\/JCO.2005.03.139","article-title":"Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non\u2013small-cell lung cancer","volume":"23","author":"Wang","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2011.06.013_bb0020","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1096\/fj.99-1078rev","article-title":"p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect","volume":"14","author":"Blagosklonny","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.humpath.2011.06.013_bb0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/S1516-84842002000200004","article-title":"A import\u00e2ncia do gene p53 na carcinog\u00eanese humana","volume":"24","author":"Fett-Conte","year":"2002","journal-title":"Rev Bras Hematol Hemoter"},{"key":"10.1016\/j.humpath.2011.06.013_bb0030","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1535-7163.MCT-04-0342","article-title":"p53 \u03b1-Helix mimetics antagonize p53\/MDM2 interaction and activate p53","volume":"4","author":"Chen","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.humpath.2011.06.013_bb0035","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/(SICI)1097-0215(19970822)74:4<407::AID-IJC8>3.0.CO;2-Z","article-title":"Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer","volume":"74","author":"Dong","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2011.06.013_bb0040","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000030404","article-title":"Surgical treatment of penile carcinoma: our experience from 1976 to 1997","volume":"62","author":"Ficarra","year":"1999","journal-title":"Urol Int"},{"key":"10.1016\/j.humpath.2011.06.013_bb0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0022-5347(05)64836-7","article-title":"p53 as a new prognostic factor for lymph node metastasis in penile carcinoma: analysis of 82 patients treated with amputation and bilateral lymphadenectomy","volume":"168","author":"Lopes","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.humpath.2011.06.013_bb0050","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/carcin\/23.4.541","article-title":"p53-MDM2\u2014the affair that never ends","volume":"23","author":"Alarcon-Vargas","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.humpath.2011.06.013_bb0055","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1093\/emboj\/19.19.5135","article-title":"MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis","volume":"19","author":"Ganguli","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.humpath.2011.06.013_bb0060","first-page":"101","article-title":"Immunohistochemical expression of Mdm2 and p53 in penile verrucous carcinoma","volume":"33","author":"Ouban","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.humpath.2011.06.013_bb0065","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/sj.onc.1201646","article-title":"High prognostic significance of Mdm2\/p53 co-overexpression in soft tissue sarcomas of the extremities","volume":"16","author":"W\u00fcrl","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2011.06.013_bb0070","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1200\/JCO.2000.18.7.1465","article-title":"p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series","volume":"18","author":"Cabelguenne","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2011.06.013_bb0075","first-page":"1217","article-title":"Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors","volume":"57","author":"Cordon-Cardo","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2011.06.013_bb0080","doi-asserted-by":"crossref","first-page":"14106","DOI":"10.1073\/pnas.93.24.14106","article-title":"The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2A","volume":"93","author":"Jones","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2011.06.013_bb0085","doi-asserted-by":"crossref","unstructured":"Jones S, Hancock A, Vogel H, Donehower L. Over-expression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A 1998; 95:15608-12.","DOI":"10.1073\/pnas.95.26.15608"},{"key":"10.1016\/j.humpath.2011.06.013_bb0090","doi-asserted-by":"crossref","first-page":"11250","DOI":"10.1073\/pnas.210171597","article-title":"Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study","volume":"97","author":"Lev Bar-Or","year":"2000","journal-title":"Proc Nat Acad Sci U S A"},{"key":"10.1016\/j.humpath.2011.06.013_bb0095","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1073\/pnas.98.4.1619","article-title":"A TSG101\/MDM2 regulatory loop modulates MDM2 degradation and MDM2\/p53 feedback control","volume":"98","author":"Li","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2011.06.013_bb0100","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1479-5876-7-110","article-title":"Correlation between expression of p53, p21\/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma","volume":"7","author":"Zhang","year":"2009","journal-title":"J Transl Med"},{"key":"10.1016\/j.humpath.2011.06.013_bb0105","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1159\/000011918","article-title":"Expression of p53 and vascular endothelial growth factor associated with tumor angiogenesis and prognosis in gastric cancer","volume":"55","author":"Maeda","year":"1998","journal-title":"Oncology"},{"key":"10.1016\/j.humpath.2011.06.013_bb0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1039\/B911416E","article-title":"Transcriptional control of the proliferation cluster by the tumor suppressor p53","volume":"6","author":"Brosh","year":"2010","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.humpath.2011.06.013_bb0115","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrc2723","article-title":"The first 30 years of p53: growing ever more complex","volume":"9","author":"Levine","year":"2009","journal-title":"Nat Rev Cancer"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817711002851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817711002851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:33:08Z","timestamp":1758645188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817711002851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0046817711002851"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2011.06.013","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A clinical, pathologic, and molecular study of p53 and murine double minute 2 in penile carcinogenesis and its relation to prognosis","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2011.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}