{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:41:34Z","timestamp":1791355294856,"version":"4.3.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.humpath.2012.01.011","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T11:32:18Z","timestamp":1336563138000},"page":"1866-1874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Abnormal expression of transcription factor activator protein-2\u03b1 in pathologic placentas"],"prefix":"10.1016","volume":"43","author":[{"given":"Rachel M.","family":"Sheridan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Stanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Handwerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2012.01.011_bb0005","series-title":"Pathology of the human placenta","first-page":"42","article-title":"Early development of the human placenta","author":"Benirschke","year":"2006"},{"key":"10.1016\/j.humpath.2012.01.011_bb0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00198951","article-title":"The development of the human placental villous tree","volume":"181","author":"Castellucci","year":"1990","journal-title":"Anat Embryol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0015","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.placenta.2005.01.015","article-title":"How to make a placenta: mechanisms of trophoblast cell differentiation in mice\u2014a review","volume":"26A","author":"Cross","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.humpath.2012.01.011_bb0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/path.1610","article-title":"Altered cell kinetics in cultured placental villous explants in pregnancies complicated by pre-eclampsia and intrauterine growth restriction","volume":"204","author":"Crocker","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1477-7827-5-6","article-title":"Control of human trophoblastic function","volume":"5","author":"Lunghi","year":"2007","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0030","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/S0024-3205(01)01299-1","article-title":"Differential expression of AP-2gamma and AP-2alpha during human trophoblast differentiation","volume":"69","author":"Richardson","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.humpath.2012.01.011_bb0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1152\/physiolgenomics.2001.6.2.105","article-title":"Microarray analysis of trophoblast differentiation: gene expression reprogramming in key gene function categories","volume":"6","author":"Aronow","year":"2001","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.humpath.2012.01.011_bb0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physiolgenomics.00181.2003","article-title":"Critical role for transcription factor AP-2alpha in human trophoblast differentiation","volume":"18","author":"Cheng","year":"2004","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.humpath.2012.01.011_bb0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0303-7207(99)00209-9","article-title":"Activator protein-2 regulates human placental lactogen gene expression","volume":"160","author":"Richardson","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0050","doi-asserted-by":"crossref","first-page":"15405","DOI":"10.1074\/jbc.272.24.15405","article-title":"Regulation of the human chorionic gonadotropin alpha and beta subunit promoters by AP-2","volume":"72","author":"Johnson","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2012.01.011_bb0055","doi-asserted-by":"crossref","first-page":"25064","DOI":"10.1074\/jbc.270.42.25064","article-title":"Regulation of placenta-specific expression of the aromatase cytochrome P-450 gene. Involvement of the trophoblast-specific element binding protein","volume":"270","author":"Yamada","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2012.01.011_bb0060","doi-asserted-by":"crossref","first-page":"14003","DOI":"10.1016\/S0021-9258(19)85201-8","article-title":"Characterization of upstream activation elements essential for the expression of germ cell alkaline phosphatase in human choriocarcinoma cells","volume":"268","author":"Wada","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2012.01.011_bb0065","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1210\/endo.138.8.5329","article-title":"The proximal promoter region of the gene encoding human 17beta-hydroxysteroid dehydrogenase type 1 contains GATA, AP-2, and Sp1 response elements: analysis of promoter function in choriocarcinoma cells","volume":"138","author":"Piao","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.humpath.2012.01.011_bb0070","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1210\/en.2008-1645","article-title":"AP-2 impairs the invasion of a human extravillous trophoblast cell line","volume":"150","author":"Kotani","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.humpath.2012.01.011_bb0075","series-title":"Williams obstetrics","year":"2010"},{"key":"10.1016\/j.humpath.2012.01.011_bb0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0002-9378(78)90373-3","article-title":"Classification of obstetric diabetes","volume":"130","author":"White","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0029-7844(95)00386-X","article-title":"A United States national reference for fetal growth","volume":"87","author":"Alexander","year":"1997","journal-title":"Obstet & Gynecol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0090","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/j.placenta.2007.09.003","article-title":"Placental pathology: a systematic approach with clinical correlations","volume":"22","author":"Redline","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.humpath.2012.01.011_bb0095","article-title":"Utility of diagnosing various histological patterns of diffuse chronic hypoxic placental injury","author":"Stanek","year":"2011","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0100","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0143-4004(97)90000-X","article-title":"Oxygen and placental villous development origins of fetal hypoxia","volume":"18","author":"Kingdom","year":"1997","journal-title":"Placenta"},{"key":"10.1016\/j.humpath.2012.01.011_bb0105","series-title":"Placental pathology","author":"Kraus","year":"2004"},{"key":"10.1016\/j.humpath.2012.01.011_bb0110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1113\/jphysiol.2006.104968","article-title":"Placental adaptive responses and fetal programming","volume":"572","author":"Myatt","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0115","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.107.107607","article-title":"Placental origins of preeclampsia. Challenging the current hypothesis","volume":"51","author":"Huppertz","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.humpath.2012.01.011_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1469-7580.2008.00994.x","article-title":"A stereological perspective on placental morphology in normal and complicated pregnancies","volume":"215","author":"Mayhew","year":"2009","journal-title":"J Anat"},{"key":"10.1016\/j.humpath.2012.01.011_bb0125","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.placenta.2006.02.011","article-title":"The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffuse conductances","volume":"28","author":"Mayhew","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.humpath.2012.01.011_bb0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/107155769800500607","article-title":"Cellular proliferation in the placenta in normal human pregnancy and pregnancy complicated by intrauterine growth restriction","volume":"5","author":"Smith","year":"1998","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.humpath.2012.01.011_bb0135","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF02899568","article-title":"Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies","volume":"60","author":"Arnoldt","year":"1991","journal-title":"Virchow Arch B Cell Pathol Incl Mol Pathol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0140","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension","volume":"277","author":"Genbacev","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.humpath.2012.01.011_bb0145","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","author":"Roberts","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.humpath.2012.01.011_bb0150","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1471-0528.2004.00071.x","article-title":"Is pre-eclampsia more than one disease?","volume":"111","author":"Vatten","year":"2004","journal-title":"BJOG"},{"key":"10.1016\/j.humpath.2012.01.011_bb0155","first-page":"118","article-title":"Term preeclampsia is associated with minimal histopathological placental features regardless of clinical severity","volume":"25","author":"Sebire","year":"2005","journal-title":"J Obstet Gynecol"},{"key":"10.1016\/j.humpath.2012.01.011_bb0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.placenta.2008.09.015","article-title":"Altered global gene expression in first trimester placentas of women destined to develop preeclampsia","volume":"30","author":"Founds","year":"2009","journal-title":"Placenta"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712000317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712000317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:33:49Z","timestamp":1758645229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817712000317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0046817712000317"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2012.01.011","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abnormal expression of transcription factor activator protein-2\u03b1 in pathologic placentas","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2012.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}