{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:42:39Z","timestamp":1761972159650,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.humpath.2012.01.024","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T14:46:48Z","timestamp":1345128408000},"page":"2308-2317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Loss of heterozygosity at chromosomes 1p35-pter, 4q, and 18q and protein expression differences between adenocarcinomas of the distal stomach and gastric cardia"],"prefix":"10.1016","volume":"43","author":[{"given":"Yan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2012.01.024_bb0005","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.humpath.2012.01.024_bb0010","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/ijc.24290","article-title":"Recent patterns in gastric cancer: a global overview","volume":"125","author":"Bertuccio","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2012.01.024_bb0015","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1053\/j.seminoncol.2004.04.021","article-title":"Epidemiology of upper gastrointestinal malignancies","volume":"31","author":"Crew","year":"2004","journal-title":"Semin Oncol"},{"key":"10.1016\/j.humpath.2012.01.024_bb0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/CEJ.0b013e3282b6fd97","article-title":"Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China","volume":"17","author":"He","year":"2008","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.humpath.2012.01.024_bb0025","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2008.04.013","article-title":"A rising trend of gastric cardia cancer in Gansu Province of China","volume":"269","author":"Zhou","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2012.01.024_bb0030","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1007\/s00268-005-0582-z","article-title":"Distinct recurrence pattern and outcome of adenocarcinoma of the gastric cardia in comparison with carcinoma of other regions of the stomach","volume":"30","author":"Saito","year":"2006","journal-title":"World J Surg"},{"key":"10.1016\/j.humpath.2012.01.024_bb0035","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.bjc.6603583","article-title":"Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach","volume":"96","author":"Tajima","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2012.01.024_bb0040","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0002-9440(10)64666-4","article-title":"Molecular cytogenetic evaluation of gastric cardia adenocarcinoma and precursor lesions","volume":"158","author":"van Dekken","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2012.01.024_bb0045","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/bjc.1997.578","article-title":"Allelotype analysis of adenocarcinoma of the gastric cardia","volume":"76","author":"Gleeson","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2012.01.024_bb0050","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/bjc.1996.76","article-title":"Deletion mapping on chromosome 1p in well-differentiated gastric cancer","volume":"73","author":"Ezaki","year":"1996","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2012.01.024_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1062>3.0.CO;2-R","article-title":"Correlation of histologic subtypes and replication error phenotype with comparative genomic hybridization in gastric cancer","volume":"30","author":"Wu","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.humpath.2012.01.024_bb0060","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0092-8674(02)00690-6","article-title":"Causal relationship between the loss of RUNX3 expression and gastric cancer","volume":"109","author":"Li","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2012.01.024_bb0065","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/ijc.24541","article-title":"Reduced expression and homozygous deletion of annexin A10 in gastric carcinoma","volume":"125","author":"Kim","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2012.01.024_bb0070","first-page":"4221","article-title":"Inactivation of Smad4 in gastric carcinomas","volume":"57","author":"Powell","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2012.01.024_bb0075","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/jcp.51.8.593","article-title":"Loss of heterozygosity and loss of expression of the DCC gene in gastric cancer","volume":"51","author":"Fang","year":"1998","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2012.01.024_bb0080","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1046\/j.1365-2168.1998.00940.x","article-title":"Classification of adenocarcinoma of the oesophagogastric junction","volume":"85","author":"Siewert","year":"1998","journal-title":"Br J Surg"},{"year":"2009","series-title":"AJCC cancer staging manual","key":"10.1016\/j.humpath.2012.01.024_bb0085"},{"key":"10.1016\/j.humpath.2012.01.024_bb0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0959-437X(03)00007-8","article-title":"RUNX transcription factors as key targets of TGF-beta superfamily signaling","volume":"13","author":"Ito","year":"2003","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.humpath.2012.01.024_bb0095","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/jcb.23047","article-title":"RUNX3 in oncogenic and anti-oncogenic signaling in gastrointestinal cancers","volume":"112","author":"Ito","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.humpath.2012.01.024_bb0100","first-page":"315","article-title":"Molecular pathology of RUNX3 in human carcinogenesis","volume":"1796","author":"Subramaniam","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.humpath.2012.01.024_bb0105","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1038\/onc.2010.88","article-title":"RUNX3 is multifunctional in carcinogenesis of multiple solid tumors","volume":"29","author":"Chuang","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2012.01.024_bb0110","doi-asserted-by":"crossref","first-page":"9006","DOI":"10.1158\/0008-5472.CAN-07-1320","article-title":"FBXW7\/hCDC4 is a general tumor suppressor in human cancer","volume":"67","author":"Akhoondi","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2012.01.024_bb0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature09732","article-title":"SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction","volume":"471","author":"Inuzuka","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2012.01.024_bb0120","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/elps.200700093","article-title":"Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods","volume":"28","author":"Yamamoto","year":"2007","journal-title":"Electrophoresis"},{"key":"10.1016\/j.humpath.2012.01.024_bb0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.bjc.6605429","article-title":"Collagen and calcium-binding EGF domains 1 is frequently inactivated in ovarian cancer by aberrant promoter hypermethylation and modulates cell migration and survival","volume":"102","author":"Barton","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2012.01.024_bb0130","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/ng.484","article-title":"Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans","volume":"41","author":"Alders","year":"2009","journal-title":"Nat Genet"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712001384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712001384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:33:32Z","timestamp":1758645212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817712001384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0046817712001384"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2012.01.024","relation":{},"ISSN":["0046-8177"],"issn-type":[{"type":"print","value":"0046-8177"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of heterozygosity at chromosomes 1p35-pter, 4q, and 18q and protein expression differences between adenocarcinomas of the distal stomach and gastric cardia","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2012.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}