{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:47:15Z","timestamp":1790063235015,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.humpath.2012.05.021","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T20:30:24Z","timestamp":1347913824000},"page":"336-345","source":"Crossref","is-referenced-by-count":24,"title":["The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration"],"prefix":"10.1016","volume":"44","author":[{"given":"Upeka","family":"Senanayake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Leuschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heimo","family":"Strohmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Hadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Hoefler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Guertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2012.05.021_bb0005","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/mpo.2950210305","article-title":"Epidemiology of Wilms tumor","volume":"21","author":"Breslow","year":"1993","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/01913128709048329","article-title":"Ultrastructure and histogenesis of the renal tumors of childhood: an overview","volume":"11","author":"Mierau","year":"1987","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0015","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1681\/ASN.V134977","article-title":"Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development","volume":"13","author":"Dekel","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0020","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00849241","article-title":"Early organogenesis of the kidney","volume":"1","author":"Saxen","year":"1987","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0025","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.cellbio.22.010305.104340","article-title":"The cellular basis of kidney development","volume":"22","author":"Dressler","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1523-1755.2002.00164.x","article-title":"Stem cells in the kidney","volume":"61","author":"Al-Awqati","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.humpath.2012.05.021_bb0035","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1634\/stemcells.2007-0322","article-title":"Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes","volume":"26","author":"Metsuyanim","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.humpath.2012.05.021_bb0040","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/(SICI)1096-8628(19981002)79:4<260::AID-AJMG6>3.0.CO;2-Q","article-title":"Wilms tumor genetics","volume":"79","author":"Huff","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.humpath.2012.05.021_bb0045","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1038\/cddis.2011.105","article-title":"Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms tumor onset","volume":"2","author":"Maschietto","year":"2011","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.humpath.2012.05.021_bb0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/pbc.24025","article-title":"SIX1 protein expression selectively identifies blastemal elements in Wilms tumor","volume":"59","author":"Sehic","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.humpath.2012.05.021_bb0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.stem.2008.05.020","article-title":"Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development","volume":"3","author":"Kobayashi","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.humpath.2012.05.021_bb0060","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1038\/sj.emboj.7601381","article-title":"Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney","volume":"25","author":"Self","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.humpath.2012.05.021_bb0065","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.semnephrol.2009.03.009","article-title":"Cell and molecular biology of kidney development","volume":"29","author":"Reidy","year":"2009","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0070","first-page":"875","article-title":"Kidneys and urinary tract","volume":"Vol. 2","author":"Bernstein","year":"1997"},{"key":"10.1016\/j.humpath.2012.05.021_bb0075","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1681\/ASN.2006111282","article-title":"Six2 and BMP4 mutations associate with anomalous kidney development","volume":"19","author":"Weber","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0080","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00428-006-0225-2","article-title":"Genetic clonality is a feature unifying nephroblastomas regardless of the variety of morphological subtypes","volume":"449","author":"Guertl","year":"2006","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2012.05.021_bb0085","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/978-1-59745-522-0_23","article-title":"Methylight","volume":"507","author":"Campan","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0090","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1158\/0008-5472.CAN-10-0622","article-title":"Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis","volume":"70","author":"Balaguer","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2012.05.021_bb0095","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1128\/MCB.00465-07","article-title":"A Hox-Eya-Pax complex regulates early kidney developmental gene expression","volume":"27","author":"Gong","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0100","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/sj.ki.5002784","article-title":"Stem cells in the embryonic kidney","volume":"73","author":"Nishinkamura","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.humpath.2012.05.021_bb0105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.devcel.2005.05.016","article-title":"Wnt9b plays a central role in the regulation of in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system","volume":"9","author":"Carroll","year":"2005","journal-title":"Dev Cell"},{"key":"10.1016\/j.humpath.2012.05.021_bb0110","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/onc.2008.455","article-title":"Canonical WNT signalling determines lineage specificity in Wilms Tumour","volume":"28","author":"Fuzukawa","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2012.05.021_bb0115","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1158\/1078-0432.CCR-09-2890","article-title":"Children's Cancer and Leukaemia Group; SIOP Wilms' Tumour Biology Group. Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilm's tumor","volume":"16","author":"Williams","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2012.05.021_bb0120","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1158\/1078-0432.CCR-09-0312","article-title":"Subsets of very low risk Wilms tumor show distinctive gene expression, histologic and clinical features","volume":"15","author":"Sredni","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2012.05.021_bb0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000155210","article-title":"Molecular profiling of isolated histological components of Wilms tumor implicates a common role for the Wnt signaling pathway in kidney and tumor development","volume":"75","author":"Maschietto","year":"2008","journal-title":"Oncology"},{"key":"10.1016\/j.humpath.2012.05.021_bb0130","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0002-9440(10)61166-2","article-title":"Gene expression in Wilms tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition","volume":"160","author":"Li","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0135","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1111\/j.1582-4934.2008.00607.x","article-title":"Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem\/progenitor cell population","volume":"13","author":"Pode-Shakked","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.humpath.2012.05.021_bb0140","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/A:1011167924230","article-title":"Clinical impact of histologic subtypes in localized non-anaplastic nephroblastoma treated according to the trial and study SIOP-9\/GPOH","volume":"12","author":"Weirich","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0145","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000326769","article-title":"Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas","volume":"78","author":"Guertl","year":"2011","journal-title":"Pathobiology"},{"key":"10.1016\/j.humpath.2012.05.021_bb0150","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s00467-007-0466-6","article-title":"Expression profiles of congenital renal dysplasia reveal new insights into renal development and disease","volume":"22","author":"Jain","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0155","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1096-911X(199611)27:5<440::AID-MPO9>3.0.CO;2-M","article-title":"Pax-2, kidney development and oncogenesis","volume":"27","author":"Dressler","year":"1996","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0160","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00428-002-0685-y","article-title":"Genetic progression of renal cell carcinoma","volume":"441","author":"Moch","year":"2002","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2012.05.021_bb0165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/jcp.21736","article-title":"Differences amid bone marrow and cord blood hematopoietic stem\/progenitor cell division kinetics","volume":"220","author":"DaSilva","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.humpath.2012.05.021_bb0170","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0092-8674(00)81867-X","article-title":"Regulatory mechanisms in stem cell biology","volume":"88","author":"Morrison","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2012.05.021_bb0175","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1038\/onc.2010.557","article-title":"Lim-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma","volume":"30","author":"Dormoy","year":"2010","journal-title":"Oncogene"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712001979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712001979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T09:06:09Z","timestamp":1643447169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817712001979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0046817712001979"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2012.05.021","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}