{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:59:42Z","timestamp":1769025582844,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.humpath.2012.07.005","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T08:01:42Z","timestamp":1350374502000},"page":"598-605","source":"Crossref","is-referenced-by-count":25,"title":["Chronic lymphocytic leukemia with t(14;18)(q32;q21)"],"prefix":"10.1016","volume":"44","author":[{"given":"Guilin","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley E.","family":"Banks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel L.","family":"Sargent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne V.","family":"Abruzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2012.07.005_bb0005","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1056\/NEJM199510193331606","article-title":"Chronic lymphocytic leukemia","volume":"333","author":"Rozman","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0010","first-page":"1640","article-title":"The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"8","author":"Matutes","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2012.07.005_bb0015","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","article-title":"Genomic aberrations and survival in chronic lymphocytic leukemia","volume":"343","author":"Dohner","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0020","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1056\/NEJM199009133231105","article-title":"Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities","volume":"323","author":"Juliusson","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0025","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/01.GIM.0000105741.57923.08","article-title":"A set of commercially available fluorescent in-situ hybridization probes efficiently detects cytogenetic abnormalities in patients with chronic lymphocytic leukemia","volume":"6","author":"Goorha","year":"2004","journal-title":"Genet Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0030","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cancergencyto.2009.08.021","article-title":"Genetic and immunophenotypic profile of IGH@ rearrangement detected by fluorescence in situ hybridization in 149 cases of B-cell chronic lymphocytic leukemia","volume":"196","author":"Lu","year":"2010","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.humpath.2012.07.005_bb0035","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1182\/blood-2005-05-2093","article-title":"Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia","volume":"107","author":"Mayr","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0040","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1309\/AJCPOEFP3SLX6HXJ","article-title":"Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features","volume":"135","author":"Huh","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2141.2008.07227.x","article-title":"Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis","volume":"142","author":"Cavazzini","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0050","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJM198211113072002","article-title":"Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma","volume":"307","author":"Yunis","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0055","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.5858\/2002-126-1543-CLLWTA","article-title":"Chronic lymphocytic leukemia with t(14;18) and trisomy 12","volume":"126","author":"Sen","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0060","doi-asserted-by":"crossref","first-page":"410","DOI":"10.5858\/2005-129-410-DOQIBC","article-title":"Detection of t(14;18)(q32;q21) in B-cell chronic lymphocytic leukemia","volume":"129","author":"Kern","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0925-5710(97)00110-2","article-title":"Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia","volume":"67","author":"Kojima","year":"1998","journal-title":"Int J Hematol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0070","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1365-2141.1992.tb03006.x","article-title":"t(14;18) and bcl-2 gene rearrangement in a B-chronic lymphocytic leukaemia","volume":"81","author":"Jonveaux","year":"1992","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0075","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1038\/sj.leu.2404935","article-title":"Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping","volume":"21","author":"Haferlach","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2012.07.005_bb0080","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/leu.2009.44","article-title":"Translocation t(14;18) is not associated with inferior outcome in chronic lymphocytic leukemia","volume":"23","author":"Put","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2012.07.005_bb0085","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2141.2012.09178.x","article-title":"In non-follicular lymphoproliferative disorders, IGH\/BCL2-fusion is not restricted to chronic lymphocytic leukaemia","volume":"158","author":"Baseggio","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0090","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ajcp\/108.4.378","article-title":"Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)","volume":"108","author":"Moreau","year":"1997","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0095","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/modpathol.3800145","article-title":"Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma","volume":"17","author":"Admirand","year":"2004","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0100","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1172\/JCI3009","article-title":"Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors","volume":"102","author":"Fais","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2012.07.005_bb0105","series-title":"An international system for human cytogenetics nomenclature","year":"2009"},{"key":"10.1016\/j.humpath.2012.07.005_bb0110","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1182\/blood-2005-12-051458","article-title":"Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia","volume":"109","author":"Wierda","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0115","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1182\/blood.V81.10.2702.2702","article-title":"Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia","volume":"81","author":"Escudier","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1046\/j.1365-2141.1996.d01-1478.x","article-title":"Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients","volume":"92","author":"Matutes","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0125","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2169\/internalmedicine.50.4339","article-title":"CD5-positive follicular lymphoma: a case report and literature review","volume":"50","author":"Sekiguchi","year":"2011","journal-title":"Intern Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0130","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2141.2007.06868.x","article-title":"MicroRNAs in the pathogeny of chronic lymphocytic leukaemia","volume":"139","author":"Nicoloso","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0135","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0140","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0145","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1200\/JCO.2005.03.7184","article-title":"Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia","volume":"24","author":"Krober","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2012.07.005_bb0150","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1182\/blood.V100.4.1410.h81602001410_1410_1416","article-title":"V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia","volume":"100","author":"Krober","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0155","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1182\/blood.V95.9.2922.009k38_2922_2929","article-title":"Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load","volume":"95","author":"Aarts","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0160","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood.V78.6.1561.1561","article-title":"Ig VH gene expression among human follicular lymphomas","volume":"78","author":"Bahler","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2012.07.005_bb0165","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJMoa023143","article-title":"ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia","volume":"348","author":"Crespo","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2012.07.005_bb0170","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0165-4608(85)90152-9","article-title":"Abnormal\/normal metaphase ratio and prognosis in chronic B-lymphocytic leukemia","volume":"18","author":"Juliusson","year":"1985","journal-title":"Cancer Genet Cytogenet"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712002456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817712002456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T08:22:10Z","timestamp":1643530930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817712002456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0046817712002456"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2012.07.005","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}