{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:09:50Z","timestamp":1793905790989,"version":"4.8.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070536"],"award-info":[{"award-number":["81070536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.humpath.2013.10.001","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T23:31:32Z","timestamp":1382052692000},"page":"372-381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["EphB2 promotes cervical cancer progression by inducing epithelial-mesenchymal transition"],"prefix":"10.1016","volume":"45","author":[{"given":"Qing","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yane","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2013.10.001_bb0005","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.humpath.2013.10.001_bb0010","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.devcel.2008.05.009","article-title":"Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis","volume":"14","author":"Yang","year":"2008","journal-title":"Dev Cell"},{"key":"10.1016\/j.humpath.2013.10.001_bb0015","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2013.10.001_bb0020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrc2620","article-title":"Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits","volume":"9","author":"Polyak","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.humpath.2013.10.001_bb0025","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/neuonc\/nor102","article-title":"Role of Eph\/ephrin tyrosine kinase in malignant glioma","volume":"13","author":"Nakada","year":"2011","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.humpath.2013.10.001_bb0030","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrm856","article-title":"Mechanisms and functions of Eph and ephrin signalling","volume":"3","author":"Kullander","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.humpath.2013.10.001_bb0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)01015-2","article-title":"Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB\/ephrinB","volume":"111","author":"Batlle","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2013.10.001_bb0040","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0002-9440(10)62998-7","article-title":"EphB2\/R-Ras signaling regulates glioma cell adhesion, growth, and invasion","volume":"167","author":"Nakada","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2013.10.001_bb0045","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1158\/0008-5472.CAN-08-3232","article-title":"Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression","volume":"69","author":"Kumar","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2013.10.001_bb0050","doi-asserted-by":"crossref","first-page":"15418","DOI":"10.1073\/pnas.0707210104","article-title":"Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors","volume":"104","author":"Kosinski","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2013.10.001_bb0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijgo.2009.02.009","article-title":"Revised FIGO staging for carcinoma of the cervix","volume":"105","author":"Pecorelli","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.humpath.2013.10.001_bb0060","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1158\/0008-5472.CAN-07-1486","article-title":"Identification of tumorsphere- and tumor-initiating cells in HER2\/Neu-induced mammary tumors","volume":"67","author":"Liu","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2013.10.001_bb0065","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2013.10.001_bb0070","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1073\/pnas.96.24.13813","article-title":"An Eph receptor regulates integrin activity through R-Ras","volume":"96","author":"Zou","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2013.10.001_bb0075","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1158\/0008-5472.CAN-03-3667","article-title":"The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells","volume":"64","author":"Nakada","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2013.10.001_bb0080","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/gcc.20418","article-title":"Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes","volume":"46","author":"Narayan","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.humpath.2013.10.001_bb0085","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2013.10.001_bb0090","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1172\/JCI38019","article-title":"Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease","volume":"119","author":"Acloque","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2013.10.001_bb0095","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ygyno.2011.09.003","article-title":"Correlation of TWIST2 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma","volume":"124","author":"Li","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.humpath.2013.10.001_bb0100","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3892\/ijo.2013.1852","article-title":"Low-dose radiation-induced epithelial-mesenchymal transition through NF-kappaB in cervical cancer cells","volume":"42","author":"Yan","year":"2013","journal-title":"Int J Oncol"},{"key":"10.1016\/j.humpath.2013.10.001_bb0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/bjc.2012.570","article-title":"Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix","volume":"108","author":"Mayer","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2013.10.001_bb0110","doi-asserted-by":"crossref","first-page":"e65189","DOI":"10.1371\/journal.pone.0065189","article-title":"Overexpression of p16(INK4a) in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human papillomavirus infection","volume":"8","author":"Steinestel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2013.10.001_bb0115","doi-asserted-by":"crossref","first-page":"e52310","DOI":"10.1371\/journal.pone.0052310","article-title":"Up-regulated miR155 reverses the epithelial-mesenchymal transition induced by EGF and increases chemo-sensitivity to cisplatin in human Caski cervical cancer cells","volume":"7","author":"Lei","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2013.10.001_bb0120","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2012.02.008","article-title":"Slug and Sox9 cooperatively determine the mammary stem cell state","volume":"148","author":"Guo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2013.10.001_bb0125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2407-12-48","article-title":"Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance","volume":"12","author":"Lopez","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.humpath.2013.10.001_bb0130","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1158\/0008-5472.CAN-11-3132","article-title":"Pten loss and RAS\/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem\/progenitor cells","volume":"72","author":"Mulholland","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2013.10.001_bb0135","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/jcp.24162","article-title":"Activated K-Ras and INK4a\/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype","volume":"228","author":"Wang","year":"2013","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.humpath.2013.10.001_bb0140","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1101\/gad.210427.112","article-title":"Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression","volume":"27","author":"Wong","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.humpath.2013.10.001_bb0145","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/carcin\/bgq199","article-title":"The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras","volume":"31","author":"Santibanez","year":"2010","journal-title":"Carcinogenesis"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817713004164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817713004164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:33:50Z","timestamp":1758645230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817713004164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0046817713004164"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2013.10.001","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EphB2 promotes cervical cancer progression by inducing epithelial-mesenchymal transition","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2013.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}