{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:11:43Z","timestamp":1790514703641,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.humpath.2014.08.014","type":"journal-article","created":{"date-parts":[[2014,9,7]],"date-time":"2014-09-07T08:08:16Z","timestamp":1410077296000},"page":"2471-2479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The detection of SRSF2 mutations in routinely processed bone marrow biopsies is useful in the diagnosis of chronic myelomonocytic leukemia"],"prefix":"10.1016","volume":"45","author":[{"given":"Birgit","family":"Federmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Abele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-7246","authenticated-orcid":false,"given":"David Santiago","family":"Rosero Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wichard","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Boiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Kanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Quintanilla-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Orazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bonzheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2014.08.014_bb0005","series-title":"WHO classification of tumours of hematopoietic and lymphoid tissues","first-page":"220","article-title":"Chronic myelomonocytic leukaemia","author":"Orazi","year":"2008"},{"key":"10.1016\/j.humpath.2014.08.014_bb0010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/ajh.23203","article-title":"Chronic myelomonocytic leukemia: 2012 update on diagnosis, risk stratification, and management","volume":"87","author":"Parikh","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0015","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/modpathol.3800707","article-title":"Chronic myelomonocytic leukemia: the role of bone marrow biopsy immunohistology","volume":"19","author":"Orazi","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0020","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/leu.2008.119","article-title":"The myelodysplastic\/myeloproliferative neoplasms: myeloproliferative diseases with dysplastic features","volume":"22","author":"Orazi","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2014.08.014_bb0025","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1365-2559.2012.04175.x","article-title":"The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias","volume":"60","author":"Rollins-Raval","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2014.08.014_bb0030","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2141.1994.tb06734.x","article-title":"The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia. Proposals by the French-American-British Cooperative Leukaemia Group","volume":"87","author":"Bennett","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0035","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.18632\/oncotarget.749","article-title":"Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia","volume":"3","author":"Chesnais","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.humpath.2014.08.014_bb0040","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/leu.2013.100","article-title":"An evolutionary perspective on chronic myelomonocytic leukemia","volume":"27","author":"Itzykson","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2014.08.014_bb0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature10496","article-title":"Frequent pathway mutations of splicing machinery in myelodysplasia","volume":"478","author":"Yoshida","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2014.08.014_bb0050","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1200\/JCO.2012.47.3314","article-title":"Prognostic score including gene mutations in chronic myelomonocytic leukemia","volume":"31","author":"Itzykson","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0055","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1182\/blood-2012-01-404863","article-title":"SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)","volume":"120","author":"Meggendorfer","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0060","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1182\/blood-2012-05-429696","article-title":"SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival","volume":"120","author":"Lasho","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0065","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/leu.2013.119","article-title":"Mutations and prognosis in primary myelofibrosis","volume":"27","author":"Vannucchi","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2014.08.014_bb0070","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2353\/jmoldx.2006.050128","article-title":"Detection of the activating JAK2 V617F mutation in paraffin-embedded trephine bone marrow biopsies of patients with chronic myeloproliferative diseases","volume":"8","author":"Horn","year":"2006","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.humpath.2014.08.014_bb0075","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2014.08.014_bb0080","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.humpath.2012.07.010","article-title":"Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR","volume":"44","author":"Bosmuller","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0085","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/modpathol.2012.165","article-title":"Development of monocytosis in patients with primary myelofibrosis indicates an accelerated phase of the disease","volume":"26","author":"Boiocchi","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0090","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1200\/JCO.2006.09.2403","article-title":"Revised response criteria for malignant lymphoma","volume":"25","author":"Cheson","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0095","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00428-009-0726-x","article-title":"The detection of CD14 and CD16 in paraffin-embedded bone marrow biopsies is useful for the diagnosis of chronic myelomonocytic leukemia","volume":"454","author":"Qubaja","year":"2009","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2014.08.014_bb0100","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2141.2008.07117.x","article-title":"Bone marrow trephine morphology and immunohistochemical findings in chronic myelomonocytic leukaemia","volume":"141","author":"Ngo","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/ajh.23373","article-title":"Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance","volume":"88","author":"Patnaik","year":"2013","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0110","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1182\/blood-2012-02-412296","article-title":"The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution","volume":"120","author":"Wu","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0115","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/path.2677","article-title":"Variable presence of KITD816V in clonal haematological non-mast cell lineage diseases associated with systemic mastocytosis (SM-AHNMD)","volume":"220","author":"Sotlar","year":"2010","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0120","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1182\/blood-2009-02-205237","article-title":"Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors","volume":"113","author":"Lim","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0125","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1182\/blood-2013-04-496448","article-title":"Comprehensive mutational profiling in advanced systemic mastocytosis","volume":"122","author":"Schwaab","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0130","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3324\/haematol.2013.095133","article-title":"SRSF2-P95 hotspot mutation is highly associated with advanced forms of mastocytosis and mutations in epigenetic regulator genes","volume":"99","author":"Hanssens","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2014.08.014_bb0135","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1136\/jcp.2009.065904","article-title":"JAK2V617F activating mutation is associated with the myeloproliferative type of chronic myelomonocytic leukaemia","volume":"62","author":"Pich","year":"2009","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2014.08.014_bb0140","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1182\/blood-2005-03-1183","article-title":"The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both \u201catypical\" myeloproliferative disorders and myelodysplastic syndromes","volume":"106","author":"Steensma","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0145","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1182\/blood-2005-05-1898","article-title":"The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia","volume":"106","author":"Levine","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0150","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1182\/blood-2005-05-1800","article-title":"JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia","volume":"106","author":"Jelinek","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.08.014_bb0155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3324\/haematol.2013.091454","article-title":"Array comparative genomic hybridization and sequencing of 23 genes in 80 patients with myelofibrosis at chronic or acute phase","volume":"99","author":"Brecqueville","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2014.08.014_bb0160","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1182\/blood-2012-11-467662","article-title":"SRSF2 mutation is present in the hypercellular and prefibrotic stage of primary myelofibrosis","volume":"121","author":"Lehmann","year":"2013","journal-title":"Blood"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681771400358X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681771400358X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T20:30:45Z","timestamp":1538253045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004681771400358X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S004681771400358X"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2014.08.014","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The detection of SRSF2 mutations in routinely processed bone marrow biopsies is useful in the diagnosis of chronic myelomonocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2014.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}