{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:44:03Z","timestamp":1790253843577,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.humpath.2014.10.015","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T20:00:36Z","timestamp":1415044836000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["BAP1 and BRAFV600E expression in benign and malignant melanocytic proliferations"],"prefix":"10.1016","volume":"46","author":[{"given":"Adriano","family":"Piris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Martin C.","family":"Mihm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai P.","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2014.10.015_bb0005","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1136\/jmedgenet-2011-100156","article-title":"Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers","volume":"48","author":"Abdel-Rahman","year":"2011","journal-title":"J Med Genet"},{"key":"10.1016\/j.humpath.2014.10.015_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/1479-5876-10-179","article-title":"BAP1 cancer syndrome: malignant mesotheliomas, uveal and cutaneous melanoma, and MBAITs","volume":"30","author":"Carbone","year":"2012","journal-title":"J Transl Med"},{"key":"10.1016\/j.humpath.2014.10.015_bb0015","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/pcmr.12006","article-title":"A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma","volume":"25","author":"Wadt","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.humpath.2014.10.015_bb0020","doi-asserted-by":"crossref","first-page":"e35295","DOI":"10.1371\/journal.pone.0035295","article-title":"Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families","volume":"7","author":"Njauw","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2014.10.015_bb0025","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ng.910","article-title":"Germline mutations in BAP1 predispose to melanocytic tumors","volume":"43","author":"Wiesner","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2014.10.015_bb0030","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/ng.912","article-title":"Germline BAP1 mutations predispose to malignant mesothelioma","volume":"28","author":"Testa","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2014.10.015_bb0035","doi-asserted-by":"crossref","first-page":"e337","DOI":"10.1200\/JCO.2011.41.2965","article-title":"Toward an improved definition of the tumor spectrum associated with BAP1 germline mutations","volume":"30","author":"Wiesner","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0040","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/cup.12133","article-title":"Clumped perinuclear BAP1 expression is a frequent finding in sporadic epithelioid Spitz tumors","volume":"40","author":"Gammon","year":"2013","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/PAS.0b013e318263648c","article-title":"Combined BRAFV600E-positive melanocytic lesions with large epithelioid cells lacking BAP1 expression and conventional nevomelanocytes","volume":"37","author":"Busam","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0050","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/PAS.0000000000000209","article-title":"Ambiguous melanocytic tumors with loss of 3p21","volume":"38","author":"Yeh","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0055","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/PAS.0b013e3182498be5","article-title":"A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression","volume":"36","author":"Wiesner","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0060","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/PAT.0b013e3283653818","article-title":"BAP1 expression cutaneous melanoma: a pilot study","volume":"45","author":"Murali","year":"2013","journal-title":"Pathology"},{"issue":"5","key":"10.1016\/j.humpath.2014.10.015_bb0065","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0046-8177(99)90193-4","article-title":"Atypical Spitz nevi\/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome","volume":"30","author":"Barnhill","year":"1999","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0070","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/archderm.135.3.282","article-title":"Spitz tumor in children. A grading system for risk stratification","volume":"135","author":"Spatz","year":"1999","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0075","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/PAS.0b013e31821375ea","article-title":"Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases","volume":"35","author":"Phadke","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/PAS.0b013e31826485c0","article-title":"Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma","volume":"37","author":"Long","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0085","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.humpath.2013.06.018","article-title":"Comparison of 2 monoclonal antibodies for immunohistochemical detection of BRAF V600E mutation in malignant melanoma, pulmonary carcinoma, gastrointestinal carcinoma, thyroid carcinoma, and gliomas","volume":"44","author":"Routhier","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0090","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/sj.onc.1201861","article-title":"BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression","volume":"16","author":"Jensen","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2014.10.015_bb0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.1999.tb09414.x","article-title":"BAP1, a candidate tumor suppressor protein that interacts with BRCA1","volume":"886","author":"Jensen","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.humpath.2014.10.015_bb0100","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1194472","article-title":"Frequent mutation of BAP1 in metastasizing uveal melanomas","volume":"330","author":"Harbour","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.humpath.2014.10.015_bb0105","first-page":"1018","article-title":"BAP1 loss defines a new class of renal cell carcinoma","volume":"43","author":"Pena-Llopis","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2014.10.015_bb0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaad.2013.10.032","article-title":"Histopathologic clues for the diagnosis of Wiesner nevus","volume":"70","author":"Llamas-Velasco","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0115","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.0303-6987.2003.00179.x","article-title":"The T1796A mutation of the BRAF gene is absent in Spitz nevi","volume":"31","author":"Palmedo","year":"2004","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.humpath.2014.10.015_bb0120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng1054","article-title":"High frequency of BRAF mutations in nevi","volume":"33","author":"Pollock","year":"2003","journal-title":"Nat Genet"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817714004420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817714004420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T20:09:28Z","timestamp":1565986168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817714004420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0046817714004420"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2014.10.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725271985.793508856","asserted-by":"object"}]},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BAP1 and BRAFV600E expression in benign and malignant melanocytic proliferations","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2014.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}