{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:43:44Z","timestamp":1789559024742,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.humpath.2014.10.021","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T23:44:14Z","timestamp":1416181454000},"page":"260-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients"],"prefix":"10.1016","volume":"46","author":[{"given":"Julia Turbiner","family":"Geyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivakumar","family":"Subramaniyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Elemento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan O.","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Orazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2014.10.021_bb0005","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.humpath.2014.10.021_bb0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.beha.2011.02.006","article-title":"Transformation of follicular lymphoma","volume":"24","author":"Lossos","year":"2011","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0015","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.humpath.2005.01.004","article-title":"Transformation of follicular lymphoma to Burkitt-like lymphoma within a single lymph node","volume":"36","author":"Mukhopadhyay","year":"2005","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3960\/jslrt.52.113","article-title":"Double-hit lymphoma with a feature of follicular lymphoma concurrent with clonally related B lymphoblastic leukemia: a preference of transformation for the bone marrow","volume":"52","author":"Kishimoto","year":"2012","journal-title":"J Clin Exp Hematop"},{"key":"10.1016\/j.humpath.2014.10.021_bb0025","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/modpathol.2011.147","article-title":"B-cell lymphomas with MYC\/8q24 rearrangements and IGH@BCL2\/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome","volume":"25","author":"Li","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/PAS.0b013e3181cd3aeb","article-title":"B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma","volume":"34","author":"Snuderl","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/gcc.2870020211","article-title":"Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11)","volume":"2","author":"Thangavelu","year":"1990","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.humpath.2014.10.021_bb0040","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/PAS.0b013e31826cb1d1","article-title":"Plasmablastic transformation of low-grade B-cell lymphomas: report on 6 cases","volume":"37","author":"Martinez","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0045","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1309\/AJCPWY1SGJ9IEAOR","article-title":"Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement","volume":"134","author":"Ouansafi","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0050","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJM198805263182106","article-title":"Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma","volume":"318","author":"De Jong","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2014.10.021_bb0055","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF01698379","article-title":"Translocation (14;18) and (8;22) in three patients with acute leukemia\/lymphoma following centrocytic\/centroblastic non-Hodgkin's lymphoma","volume":"63","author":"Fiedler","year":"1991","journal-title":"Ann Hematol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0060","first-page":"431","article-title":"Pre-B-cell leukemia with a t(8;14) and a t(14;18) translocation is preceded by follicular lymphoma","volume":"2","author":"Gauwerky","year":"1988","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2014.10.021_bb0065","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1309\/Y2YD-UNA2-C95R-AVM3","article-title":"Precursor B-lymphoblastic transformation of grade I follicle center lymphoma","volume":"113","author":"Kroft","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0070","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5858\/2004-128-210-FLWABT","article-title":"Follicular lymphoma with a Burkitt translocation\u2014predictor of an aggressive clinical course: a case report and review of the literature","volume":"128","author":"Voorhees","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2014.10.021_bb0075","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1309\/NKK3FEX2BE5L7EKB","article-title":"Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event","volume":"129","author":"Young","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0080","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1365-2559.2012.04301.x","article-title":"High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and\/or MYC gene rearrangements and a poor prognosis","volume":"61","author":"Kanagal-Shamanna","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2014.10.021_bb0085","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.3109\/10428194.2011.589548","article-title":"De novo B lymphoblastic leukemia\/lymphoma in an adult with t(14;18)(q32;q21) and c-MYC gene rearrangement involving 10p13","volume":"52","author":"Subramaniyam","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2014.10.021_bb0090","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood-2009-03-212191","article-title":"Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival","volume":"114","author":"Johnson","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.10.021_bb0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/modpathol.3800500","article-title":"Lymphoid neoplasms associated with concurrent t(14;18) and 8q24\/c-MYC translocation generally have a poor prognosis","volume":"19","author":"Kanungo","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0100","doi-asserted-by":"crossref","first-page":"e40332","DOI":"10.1371\/journal.pone.0040332","article-title":"Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma","volume":"7","author":"Jiang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2014.10.021_bb0105","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ng.892","article-title":"Analysis of the coding genome of diffuse large B-cell lymphoma","volume":"43","author":"Pasqualucci","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2014.10.021_bb0110","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1073\/pnas.1205299110","article-title":"Genetic heterogeneity of diffuse large B-cell lymphoma","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2014.10.021_bb0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1755-8166-6-34","article-title":"Characterization of a case of follicular lymphoma transformed into B-lymphoblastic leukemia","volume":"6","author":"Ning","year":"2013","journal-title":"Mol Cytogenet"},{"key":"10.1016\/j.humpath.2014.10.021_bb0120","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1080\/10428190600612909","article-title":"Molecular analysis of light-chain switch and acute lymphoblastic leukemia transformation in two follicular lymphomas: implications for lymphomagenesis","volume":"47","author":"Kobrin","year":"2006","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2014.10.021_bb0125","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2141.2006.06439.x","article-title":"Transformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms","volume":"136","author":"Davies","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0130","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/modpathol.2010.72","article-title":"Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features","volume":"23","author":"Taddesse-Heath","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0135","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2162-3619-3-4","article-title":"Ibrutinib for B cell malignancies","volume":"3","author":"Novero","year":"2014","journal-title":"Exp Hematol Oncol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-385991-4.00001-5","article-title":"Early steps of follicular lymphoma pathogenesis","volume":"111","author":"Roulland","year":"2011","journal-title":"Adv Immunol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0145","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1182\/blood-2008-08-174839","article-title":"Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone","volume":"113","author":"Carlotti","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.10.021_bb0150","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.celrep.2013.12.027","article-title":"Genetics of follicular lymphoma transformation","volume":"6","author":"Pasqualucci","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.humpath.2014.10.021_bb0155","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2014.10.021_bb0160","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(04)00419-2","article-title":"Stepwise reprogramming of B cells into macrophages","volume":"117","author":"Xie","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2014.10.021_bb0165","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1182\/blood-2007-11-124792","article-title":"Clonally related follicular lymphomas and histiocytic\/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone","volume":"111","author":"Feldman","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2014.10.021_bb0170","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.3324\/haematol.2009.021212","article-title":"Common clonal origin of an acute B-lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity","volume":"95","author":"Ratei","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2014.10.021_bb0175","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/PAS.0b013e318283099f","article-title":"Clonally related follicular lymphomas and Langerhans cell neoplasms: expanding the spectrum of transdifferentiation","volume":"37","author":"West","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0180","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00000478-200004000-00006","article-title":"Blastic\/blastoid transformation of follicular lymphoma: immunohistologic and molecular analyses of five cases","volume":"24","author":"Natkunam","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.021_bb0185","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/modpathol.2009.106","article-title":"Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma","volume":"22","author":"Chiu","year":"2009","journal-title":"Mod Pathol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817714004523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817714004523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T16:44:47Z","timestamp":1650645887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817714004523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0046817714004523"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2014.10.021","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2014.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}