{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:19:43Z","timestamp":1790450383240,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.humpath.2014.10.026","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T08:26:41Z","timestamp":1416212801000},"page":"277-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden"],"prefix":"10.1016","volume":"46","author":[{"given":"Marjorie M.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Talley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Ingan\u00e4s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Engstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Nyhlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Agr\u00e9us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Kjellstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"\u00d6st","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Andreasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2014.10.026_bb0005","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/bmj.3.5567.718","article-title":"Intestinal spirochaetosis","volume":"3","author":"Harland","year":"1967","journal-title":"Br Med J"},{"key":"10.1016\/j.humpath.2014.10.026_bb0010","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/gut.12.2.126","article-title":"Intestinal spirochaetosis","volume":"12","author":"Lee","year":"1971","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2014.10.026_bb0015","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1699-0463.1993.tb00192.x","article-title":"Human intestinal spirochaetosis in mid-Norway. A retrospective histopathological study with clinical correlations","volume":"101","author":"Lindboe","year":"1993","journal-title":"APMIS"},{"key":"10.1016\/j.humpath.2014.10.026_bb0020","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s10620-012-2305-2","article-title":"Intestinal spirochetosis: an enigmatic disease","volume":"58","author":"Anthony","year":"2013","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.humpath.2014.10.026_bb0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/jcp.39.5.535","article-title":"Isolation and characterisation of intestinal spirochaetes","volume":"39","author":"Tompkins","year":"1986","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1017\/S0950268800059434","article-title":"Intestinal spirochaetes in a Gulf Arab population","volume":"104","author":"Barrett","year":"1990","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.humpath.2014.10.026_bb0035","first-page":"133","article-title":"Intestinal spirochaetes colonizing aborigines from communities in the remote north of Western Australia","volume":"109","author":"Lee","year":"1992","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.humpath.2014.10.026_bb0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/modpathol.3800987","article-title":"Human intestinal spirochetosis in Japan; its incidence, clinicopathologic features, and genotypic identification","volume":"21","author":"Tanahashi","year":"2008","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0045","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0344-0338(87)80042-0","article-title":"Intestinal spirochaetosis. Light and electron microscopic study","volume":"182","author":"Delladetsima","year":"1987","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.humpath.2014.10.026_bb0050","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0002-9343(87)90104-5","article-title":"Intestinal spirochetosis in homosexual men","volume":"82","author":"Surawicz","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.humpath.2014.10.026_bb0055","first-page":"26","article-title":"Rectal spirochaetosis in homosexual men: the association with sexual practices, HIV infection and enteric flora","volume":"70","author":"Law","year":"1994","journal-title":"Genitourin Med"},{"key":"10.1016\/j.humpath.2014.10.026_bb0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/1066896908330203","article-title":"The histological features of intestinal spirochetosis in a series of 113 patients","volume":"18","author":"Carr","year":"2010","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0065","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1111\/j.1440-1746.2006.04606.x","article-title":"Infective colitis associated with human intestinal spirochetosis","volume":"22","author":"Calderaro","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.prp.2011.12.004","article-title":"Intestinal spirochaetosis associated with hyperplastic and adenomatous colonic polyps","volume":"208","author":"Calderaro","year":"2012","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.humpath.2014.10.026_bb0075","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2559.1995.tb01530.x","article-title":"Colonic tubular adenomas and intestinal spirochaetosis: an incompatible association","volume":"27","author":"Coyne","year":"1995","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2014.10.026_bb0080","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrgastro.2010.5","article-title":"Gastrointestinal eosinophils in health, disease and functional disorders","volume":"7","author":"Powell","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5858\/arpa.2011-0430-OA","article-title":"Lymphocytic follicles and aggregates are a determinant of mucosal damage and duration of diarrhea","volume":"137","author":"Shah","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2014.10.026_bb0090","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3109\/00365520903551332","article-title":"Assessment of normal bowel habits in the general adult population: the PopCol study","volume":"45","author":"Walter","year":"2010","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0095","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MEG.0000000000000024","article-title":"A randomly selected population sample undergoing colonoscopy: prevalence of the irritable bowel syndrome and the impact of selection factors","volume":"26","author":"Kjellstr\u00f6m","year":"2014","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/02813439308994840","article-title":"Reproducibility and validity of a postal questionnaire. The abdominal symptom study","volume":"11","author":"Agr\u00e9us","year":"1993","journal-title":"Scand J Prim Health Care"},{"key":"10.1016\/j.humpath.2014.10.026_bb0105","series-title":"Diagnosis, pathophysiology and treatment: a multinational consensus","article-title":"ROME II. The functional gastrointestinal disorders","author":"Drossman","year":"2000"},{"key":"10.1016\/j.humpath.2014.10.026_bb0110","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humpath.2014.10.026_bb0115","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1365-2559.2006.02565.x","article-title":"Intestinal spirochaetosis","volume":"49","author":"Will\u00e9n","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2014.10.026_bb0120","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3109\/00365521.2011.647062","article-title":"Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study","volume":"47","author":"Forsberg","year":"2012","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0130","doi-asserted-by":"crossref","first-page":"e5836","DOI":"10.1136\/bmj.e5836","article-title":"Irritable bowel syndrome","volume":"345","author":"Ford","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.humpath.2014.10.026_bb0135","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1080\/00365520701245629","article-title":"Human intestinal spirochetosis: analysis of the symptoms of 209 patients","volume":"42","author":"Weisheit","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0140","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1440-1746.2006.04150.x","article-title":"Intestinal spirochetosis and chronic watery diarrhea: clinical and histological response to treatment and long-term follow up","volume":"21","author":"Esteve","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0145","doi-asserted-by":"crossref","first-page":"570526","DOI":"10.1155\/2013\/570526","article-title":"Specimens from biopsies of colorectal polyps often harbor additional diagnoses","volume":"2013","author":"Chopra","year":"2013","journal-title":"Pathol Res Int"},{"key":"10.1016\/j.humpath.2014.10.026_bb0150","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-230X-13-80","article-title":"Low prevalence of \u2018classical\u2019 microscopic colitis but evidence of microscopic inflammation in Asian irritable bowel syndrome patients with diarrhoea","volume":"13","author":"Hilmi","year":"2013","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0155","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/gut.28.5.588","article-title":"Spirochaetosis of the human rectum associated with an intraepithelial mast cell and IgE plasma cell response","volume":"28","author":"Gebbers","year":"1987","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2014.10.026_bb0160","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/ajcp\/86.5.679","article-title":"Proposed pathogenic mechanism for the diarrhea associated with human intestinal spirochetes","volume":"86","author":"Rodgers","year":"1986","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2014.10.026_bb0165","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s15010-003-3145-y","article-title":"Clinical significance of human intestinal spirochaetosis\u2014a morphologic approach","volume":"31","author":"K\u00f6rner","year":"2003","journal-title":"Infection"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817714004596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817714004596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T19:10:17Z","timestamp":1598469017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817714004596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0046817714004596"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2014.10.026","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2014.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2015 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}