{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T16:55:34Z","timestamp":1689094534760},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.humpath.2015.05.012","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T12:05:20Z","timestamp":1432987520000},"page":"1315-1322","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression and clinical significance of epidermal growth factor receptor and insulin-like growth factor receptor 1 in patients with ampullary adenocarcinoma"],"prefix":"10.1016","volume":"46","author":[{"given":"Michelle","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Overman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyali","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason B.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery E.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauri R.","family":"Varadhachary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huamin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2015.05.012_bb0005","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/1471-2407-8-170","article-title":"Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma","volume":"8","author":"Westgaard","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.humpath.2015.05.012_bb0010","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/jso.21374","article-title":"Cancers of the ampulla of Vater: demographics, morphology, and survival based on 5,625 cases from the SEER program","volume":"100","author":"Albores-Saavedra","year":"2009","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1349-7006.1994.tb02077.x","article-title":"Different clinicopathologic findings in two histologic types of carcinoma of papilla of Vater","volume":"85","author":"Kimura","year":"1994","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.humpath.2015.05.012_bb0020","first-page":"1641","article-title":"The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis","volume":"54","author":"Roh","year":"2007","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.humpath.2015.05.012_bb0025","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/00000478-200407000-00005","article-title":"Carcinoma of the ampulla of Vater: comparative histologic\/immunohistochemical classification and follow-up","volume":"28","author":"Zhou","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0030","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00428-007-0444-1","article-title":"Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability","volume":"451","author":"Sessa","year":"2007","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2015.05.012_bb0035","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1200\/JCO.2012.46.8868","article-title":"Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of Vater","volume":"31","author":"Chang","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0040","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/jcp.49.6.460","article-title":"Clinical significance of K-ras oncogene activation in ampullary neoplasms","volume":"49","author":"Chung","year":"1996","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0045","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S1055-3207(02)00042-X","article-title":"Cellular and molecular biology of biliary tract cancers","volume":"11","author":"Rashid","year":"2002","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1016\/j.humpath.2015.05.012_bb0050","first-page":"3156","article-title":"K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China","volume":"8","author":"Rashid","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2015.05.012_bb0055","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/modpathol.2013.185","article-title":"Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels","volume":"27","author":"Mikhitarian","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0060","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/01.MP.0000057246.03448.26","article-title":"Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases","volume":"16","author":"McCarthy","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0065","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/PAS.0b013e3181983ef7","article-title":"Histopathologic features and microsatellite instability of cancers of the papilla of Vater and their precursor lesions","volume":"33","author":"Ruemmele","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0070","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.5858\/arpa.2012-0418-OA","article-title":"The expression of PTEN is associated with improved prognosis in patients with ampullary adenocarcinoma after pancreaticoduodenectomy","volume":"137","author":"Shroff","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2015.05.012_bb0075","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.humpath.2013.12.016","article-title":"Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma","volume":"45","author":"Guo","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0093-7754(01)90284-2","article-title":"Anticancer therapy targeting the erbB family of receptor tyrosine kinases","volume":"28","author":"Slichenmyer","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0085","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/carcin\/bgn026","article-title":"FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells","volume":"29","author":"Liu","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.humpath.2015.05.012_bb0090","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jss.2008.08.016","article-title":"IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1\/PI3K\/Akt signaling pathway in pancreatic cancer cells","volume":"160","author":"Ma","year":"2010","journal-title":"J Surg Res"},{"issue":"11 Suppl. 2","key":"10.1016\/j.humpath.2015.05.012_bb0095","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00000421-198801102-00002","article-title":"Growth factor receptors and oncogene expression in prostate cells","author":"Davies","year":"1988","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0100","first-page":"7077","article-title":"Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung","volume":"50","author":"Tateishi","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2015.05.012_bb0105","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1200\/JCO.2006.07.9525","article-title":"Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group","volume":"25","author":"Moore","year":"2007","journal-title":"J Clin Oncol"},{"issue":"13 Suppl. 1","key":"10.1016\/j.humpath.2015.05.012_bb0110","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1677\/erc.1.01275","article-title":"Growth factor receptor interplay and resistance in cancer","author":"Jones","year":"2006","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.humpath.2015.05.012_bb0115","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/modpathol.3800582","article-title":"Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer","volume":"19","author":"Ueda","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0120","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cllc.2013.08.005","article-title":"High coexpression of both EGFR and IGF1R correlates with poor patient prognosis in resected non\u2013small-cell lung cancer","volume":"15","author":"Gately","year":"2014","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.humpath.2015.05.012_bb0125","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4048\/jbc.2014.17.2.113","article-title":"Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status and a favorable prognosis in breast cancer","volume":"17","author":"Shin","year":"2014","journal-title":"J Breast Cancer"},{"key":"10.1016\/j.humpath.2015.05.012_bb0130","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1158\/1055-9965.EPI-13-0349","article-title":"Protein expression of PTEN, insulin-like growth factor I receptor (IGF-IR), and lethal prostate cancer: a prospective study","volume":"22","author":"Zu","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.humpath.2015.05.012_bb0135","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2353\/ajpath.2006.050464","article-title":"Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma","volume":"169","author":"Alvaro","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0140","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1097\/PAS.0b013e31826399d8","article-title":"Ampullary region carcinomas: definition and site specific classification with delineation of four clinicopathologically and prognostically distinct subsets in an analysis of 249 cases","volume":"36","author":"Adsay","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0145","series-title":"AJCC Cancer Staging Manual","year":"2010"},{"key":"10.1016\/j.humpath.2015.05.012_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1750-3639.2002.tb00426.x","article-title":"Tissue microarrays: applications in neuropathology research, diagnosis, and education","volume":"12","author":"Wang","year":"2002","journal-title":"Brain Pathol"},{"key":"10.1016\/j.humpath.2015.05.012_bb0155","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1365-2559.2008.03028.x","article-title":"Assessment of a HER2 scoring system for gastric cancer: results from a validation study","volume":"52","author":"Hofmann","year":"2008","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2015.05.012_bb0160","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/1471-2407-13-392","article-title":"IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer","volume":"13","author":"Hirakawa","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.humpath.2015.05.012_bb0165","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1002\/cncr.26661","article-title":"Epidermal growth factor receptor and insulin-like growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma","volume":"118","author":"Valsecchi","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2015.05.012_bb0170","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1074\/jbc.M303975200","article-title":"Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor\/vascular endothelial growth factor expression in pancreatic cancer cells","volume":"279","author":"Neid","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2015.05.012_bb0175","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s10637-012-9811-0","article-title":"Clinical development of insulin-like growth factor receptor-1 (IGF-1R) inhibitors: at the crossroad?","volume":"30","author":"Gombos","year":"2012","journal-title":"Investig New Drugs"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817715001860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817715001860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T17:39:02Z","timestamp":1566754742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817715001860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0046817715001860"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2015.05.012","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression and clinical significance of epidermal growth factor receptor and insulin-like growth factor receptor 1 in patients with ampullary adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2015.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}