{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:54:14Z","timestamp":1773424454435,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.humpath.2015.12.020","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T04:29:53Z","timestamp":1452832193000},"page":"86-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Endothelial activation, lymphangiogenesis, and humoral rejection of kidney transplants"],"prefix":"10.1016","volume":"51","author":[{"given":"Sharon","family":"Phillips","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0252-3919","authenticated-orcid":false,"given":"Meghan","family":"Kapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes B.","family":"Fogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna A.","family":"Giannico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2015.12.020_bb0005","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","article-title":"Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence","volume":"12","author":"Sellares","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/TP.0b013e3181e065de","article-title":"Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure","volume":"90","author":"Gaston","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.humpath.2015.12.020_bb0015","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1111\/j.1600-6143.2009.02819.x","article-title":"Effect of antibodies on endothelium","volume":"9","author":"Zhang","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0020","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-6143.2011.03836.x","article-title":"A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody","volume":"12","author":"Hirohashi","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0025","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/ki.1993.187","article-title":"Capillary deposition of C4d complement fragment and early renal graft loss","volume":"43","author":"Feucht","year":"1993","journal-title":"Kidney Int"},{"key":"10.1016\/j.humpath.2015.12.020_bb0030","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/ki.2011.497","article-title":"Pros and cons for C4d as a biomarker","volume":"81","author":"Cohen","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.humpath.2015.12.020_bb0035","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/ajt.12150","article-title":"Molecular diagnosis of antibody-mediated rejection in human kidney transplants","volume":"13","author":"Sellares","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0040","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/j.1600-6143.2009.02761.x","article-title":"Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining","volume":"9","author":"Sis","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0045","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1600-6143.2006.01638.x","article-title":"Lymphatic neoangiogenesis in human renal allografts: results from sequential protocol biopsies","volume":"7","author":"Stuht","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0050","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4049\/jimmunol.0903180","article-title":"Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation","volume":"184","author":"Dietrich","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/TP.0b013e31821d2661","article-title":"Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival","volume":"92","author":"Yin","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.humpath.2015.12.020_bb0060","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/modpathol.3800589","article-title":"Renal lymphatics, and lymphatic involvement in sinus vein invasive (pT3b) clear cell renal cell carcinoma: a study of 40 cases","volume":"19","author":"Bonsib","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0065","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1681\/ASN.V8121930","article-title":"Evaluation of pathologic criteria for acute renal allograft rejection: reproducibility, sensitivity, and clinical correlation","volume":"8","author":"Colvin","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0070","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1600-6143.2008.02159.x","article-title":"Banff 07 classification of renal allograft pathology: updates and future directions","volume":"8","author":"Solez","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0075","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/ajt.12590","article-title":"Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions","volume":"14","author":"Haas","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0080","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1681\/ASN.2004121130","article-title":"Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation","volume":"16","author":"Hourmant","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0085","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s000180050226","article-title":"Endothelial cells as antigen-presenting cells: role in human transplant rejection","volume":"54","author":"Rose","year":"1998","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.humpath.2015.12.020_bb0090","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/00007890-199606150-00007","article-title":"Pathologic features of acute renal allograft rejection associated with donor-specific antibody. Analysis using the Banff grading schema","volume":"61","author":"Trpkov","year":"1996","journal-title":"Transplantation"},{"key":"10.1016\/j.humpath.2015.12.020_bb0095","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1681\/ASN.2007010073","article-title":"Antibody-mediated renal allograft rejection: diagnosis and pathogenesis","volume":"18","author":"Colvin","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0100","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/01.CIR.95.1.191","article-title":"Adhesion molecule P-selectin and vascular cell adhesion molecule-1 in enhanced heart allograft arteriosclerosis in the rat","volume":"95","author":"Koskinen","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.humpath.2015.12.020_bb0105","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1681\/ASN.2006111261","article-title":"Importance of donor- and recipient-derived selectins in cardiac allograft rejection","volume":"18","author":"Izawa","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0110","doi-asserted-by":"crossref","first-page":"12145","DOI":"10.1073\/pnas.1303676111","article-title":"Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection","volume":"111","author":"Sarraj","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2015.12.020_bb0115","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1097\/01.ASN.0000142425.23036.AC","article-title":"Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines","volume":"15","author":"Langer","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2015.12.020_bb0125","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.4049\/jimmunol.178.11.6725","article-title":"Cutting edge: regulatory T cells induce CD4+CD25\u2212Foxp3\u2212 T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta","volume":"178","author":"Xu","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0008-8749(91)90065-J","article-title":"Endothelial cell lymphocyte function\u2013associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells","volume":"137","author":"Savage","year":"1991","journal-title":"Cell Immunol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0135","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.4049\/jimmunol.148.12.3753","article-title":"Alloantigenicity of human endothelial cells. 1. Frequency and phenotype of human T helper lymphocytes that can react to allogeneic endothelial cells","volume":"148","author":"Adams","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0140","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0966-3274(94)90013-2","article-title":"Human endothelial stimulation of allogeneic T cells via a CTLA-4 independent pathway","volume":"2","author":"Page","year":"1994","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0145","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.4049\/jimmunol.163.5.2667","article-title":"Human endothelial cells augment early CD40 ligand expression in activated CD4+ T cells through LFA-3-mediated stabilization of mRNA","volume":"163","author":"Murakami","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2015.12.020_bb0150","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1073\/pnas.1011811108","article-title":"Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions","volume":"108","author":"Taflin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2015.12.020_bb0155","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1111\/ajt.12859","article-title":"The clinical spectrum of de novo donor-specific antibodies in pediatric renal transplant recipients","volume":"14","author":"Kim","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0160","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1111\/j.1600-6143.2010.03261.x","article-title":"A critical appraisal of methods to grade transplant glomerulitis in renal allograft biopsies","volume":"10","author":"Batal","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.humpath.2015.12.020_bb0165","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MOT.0000000000000189","article-title":"T-cell\u2013mediated rejection of the kidney in the era of donor-specific antibodies: diagnostic challenges and clinical significance","volume":"20","author":"Randhawa","year":"2015","journal-title":"Curr Opin Organ Transplant"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T13:58:51Z","timestamp":1692194331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817716000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":33,"alternative-id":["S0046817716000228"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2015.12.020","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial activation, lymphangiogenesis, and humoral rejection of kidney transplants","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2015.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}