{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:42:06Z","timestamp":1769204526617,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.humpath.2016.02.003","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T22:08:29Z","timestamp":1456956509000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Could prominent airway-centered fibroblast foci in lung biopsies predict underlying chronic microaspiration in idiopathic pulmonary fibrosis patients?"],"prefix":"10.1016","volume":"53","author":[{"given":"Melanie C.","family":"Bois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-2272","authenticated-orcid":false,"given":"Jay H.","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunhee S.","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2016.02.003_bb0005","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0010","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.mayocp.2014.03.016","article-title":"Idiopathic pulmonary fibrosis: evolving concepts","volume":"89","author":"Ryu","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.humpath.2016.02.003_bb0015","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1164\/rccm.201110-1842ED","article-title":"Idiopathic pulmonary fibrosis: increased survival with \u201cgastroesophageal reflux therapy\": fact or fallacy?","volume":"184","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0020","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1164\/ajrccm.164.7.2003140","article-title":"Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model","volume":"164","author":"King","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/CPM.0000000000000031","article-title":"The role of gastroesophageal reflux and microaspiration in idiopathic pulmonary fibrosis","volume":"21","author":"Lee","year":"2014","journal-title":"Clin Pulm Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0030","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.rmed.2014.03.015","article-title":"The burden of idiopathic pulmonary fibrosis: an unmet public health need","volume":"108","author":"Lee","year":"2014","journal-title":"Respir Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0035","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","article-title":"An official ATS\/ERS\/JRS\/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline","volume":"192","author":"Raghu","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0040","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/01.pas.0000213341.70852.9d","article-title":"Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fibrotic interstitial pneumonias","volume":"31","author":"Churg","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.02.003_bb0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S2213-2600(13)70045-6","article-title":"Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study","volume":"1","author":"Noth","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0055","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ng.2609","article-title":"Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis","volume":"45","author":"Fingerlin","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2016.02.003_bb0060","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa1013660","article-title":"A common MUC5B promoter polymorphism and pulmonary fibrosis","volume":"364","author":"Seibold","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gtc.2013.11.006","article-title":"Epidemiology of gastroesophageal reflux disease","volume":"43","author":"Rubenstein","year":"2014","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.humpath.2016.02.003_bb0070","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1183\/09031936.06.00037005","article-title":"High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis","volume":"27","author":"Raghu","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.humpath.2016.02.003_bb0075","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1378\/chest.69.4.512","article-title":"Pulmonary fibrosis associated with tracheobronchial aspiration. A study of the frequency of hiatal hernia and gastroesophageal reflux in interstitial pulmonary fibrosis of obscure etiology","volume":"69","author":"Mays","year":"1976","journal-title":"Chest"},{"key":"10.1016\/j.humpath.2016.02.003_bb0080","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1378\/chest.129.3.794","article-title":"Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: a case series","volume":"129","author":"Raghu","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.humpath.2016.02.003_bb0085","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1164\/rccm.201101-0138OC","article-title":"Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis","volume":"184","author":"Lee","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0090","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11605-013-2333-z","article-title":"Idiopathic pulmonary fibrosis and gastroesophageal reflux. Implications for treatment","volume":"18","author":"Allaix","year":"2014","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.humpath.2016.02.003_bb0095","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1513\/AnnalsATS.201310-360OC","article-title":"The spectrum of lung disease due to chronic occult aspiration","volume":"11","author":"Cardasis","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.humpath.2016.02.003_bb0100","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1378\/chest.14-1049","article-title":"Aspiration-related pulmonary syndromes","volume":"147","author":"Hu","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.humpath.2016.02.003_bb0105","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.amjmed.2009.07.033","article-title":"Does chronic microaspiration cause idiopathic pulmonary fibrosis?","volume":"123","author":"Lee","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.resinv.2013.05.004","article-title":"Nine pulmonary aspiration syndrome cases of atypical clinical presentation, in which the final diagnosis was obtained by histological examinations","volume":"52","author":"Shimada","year":"2014","journal-title":"Respir Investig"},{"key":"10.1016\/j.humpath.2016.02.003_bb0115","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/msj.20088","article-title":"Gastroesophageal reflux disease and idiopathic pulmonary fibrosis","volume":"76","author":"Pashinsky","year":"2009","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0120","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3181\/0801-RM-17","article-title":"Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity","volume":"233","author":"Downing","year":"2008","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.humpath.2016.02.003_bb0125","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4065\/81.2.172","article-title":"Diffuse bronchiolar disease due to chronic occult aspiration","volume":"81","author":"Barnes","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.humpath.2016.02.003_bb0130","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/PAS.0b013e3182092bb1","article-title":"Histopathology of aspiration pneumonia not associated with food or other particulate matter: a clinicopathologic study of 10 cases diagnosed on biopsy","volume":"35","author":"Yousem","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.02.003_bb0135","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1164\/ajrccm.157.4.9707039","article-title":"Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification","volume":"157","author":"Katzenstein","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0140","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1164\/ajrccm.164.6.2001056","article-title":"Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality","volume":"164","author":"King","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl 8A","key":"10.1016\/j.humpath.2016.02.003_bb0145","doi-asserted-by":"crossref","first-page":"51S","DOI":"10.1016\/S0002-9343(01)00821-X","article-title":"Supraesophageal complications of reflux disease and hiatal hernia","volume":"111","author":"Kahrilas","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0150","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1183\/09031936.00099910","article-title":"Prevalence of hiatal hernia by blinded multidetector CT in patients with idiopathic pulmonary fibrosis","volume":"39","author":"Noth","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.humpath.2016.02.003_bb0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.anndiagpath.2007.07.002","article-title":"Bronchiolitis interstitial pneumonitis: a pathologic study of 31 lung biopsies with features intermediate between bronchiolitis obliterans organizing pneumonia and usual interstitial pneumonitis, with clinical correlation","volume":"12","author":"Mark","year":"2008","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.humpath.2016.02.003_bb0160","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1078\/0344-0338-00305","article-title":"Centrilobular fibrosis: a novel histological pattern of idiopathic interstitial pneumonia","volume":"198","author":"de Carvalho","year":"2002","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.humpath.2016.02.003_bb0165","doi-asserted-by":"crossref","first-page":"984","DOI":"10.5858\/arpa.2013-0383-RA","article-title":"Interstitial lung diseases that are difficult to classify: A review of bronchiolocentric interstitial lung disease","volume":"139","author":"Virk","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2016.02.003_bb0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12931-015-0213-7","article-title":"Airway-centered interstitial fibrosis: etiology, clinical findings and prognosis","volume":"16","author":"Kuranishi","year":"2015","journal-title":"Respir Res"},{"key":"10.1016\/j.humpath.2016.02.003_bb0175","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1365-2559.2012.04322.x","article-title":"Pathological differentiation of chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis\/usual interstitial pneumonia","volume":"61","author":"Takemura","year":"2012","journal-title":"Histopathology"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716000654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716000654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T05:53:19Z","timestamp":1654494799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817716000654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":35,"alternative-id":["S0046817716000654"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2016.02.003","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Could prominent airway-centered fibroblast foci in lung biopsies predict underlying chronic microaspiration in idiopathic pulmonary fibrosis patients?","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2016.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}