{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:17:10Z","timestamp":1779905830084,"version":"3.53.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.humpath.2016.02.022","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T22:20:20Z","timestamp":1459462820000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei"],"prefix":"10.1016","volume":"54","author":[{"given":"Pirjo","family":"Nummela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannele","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-4609","authenticated-orcid":false,"given":"Petrus","family":"J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lepist\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Ristim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2016.02.022_bb0005","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1136\/jclinpath-2012-200843","article-title":"Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases","volume":"65","author":"Carr","year":"2012","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0010","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/BF02554625","article-title":"Malignant pseudomyxoma peritonei of colonic origin. Natural history and presentation of a curative approach to treatment","volume":"30","author":"Sugarbaker","year":"1987","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.humpath.2016.02.022_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/1457496913490463","article-title":"Feasibility of radical cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendiceal origin","volume":"102","author":"J\u00e4rvinen","year":"2013","journal-title":"Scand J Surg"},{"key":"10.1016\/j.humpath.2016.02.022_bb0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ejso.2013.12.021","article-title":"Pre-operative tumour marker status predicts recurrence and survival after complete cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal pseudomyxoma peritonei: analysis of 519 patients","volume":"40","author":"Taflampas","year":"2014","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/scbi.1998.0119","article-title":"The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues","volume":"9","author":"Hammarstr\u00f6m","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0030","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/clinchem\/47.4.624","article-title":"Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?","volume":"47","author":"Duffy","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.humpath.2016.02.022_bb0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12253-014-9791-9","article-title":"Association of serum levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and disease characteristics in colorectal cancer","volume":"21","author":"Zhong","year":"2015","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.humpath.2016.02.022_bb0040","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/clinchem\/29.3.549","article-title":"Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9","volume":"29","author":"Del Villano","year":"1983","journal-title":"Clin Chem"},{"key":"10.1016\/j.humpath.2016.02.022_bb0045","first-page":"5501","article-title":"Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer","volume":"47","author":"Tempero","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2016.02.022_bb0050","doi-asserted-by":"crossref","first-page":"21994","DOI":"10.1074\/jbc.272.35.21994","article-title":"Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3\/1,4)-fucosyltransferase, Fuc-TIII","volume":"272","author":"Elmgren","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2016.02.022_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1476-4598-13-129","article-title":"MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress","volume":"13","author":"Felder","year":"2014","journal-title":"Mol Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0060","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJM198310133091503","article-title":"A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer","volume":"309","author":"Bast","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2016.02.022_bb0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ctrv.2011.04.002","article-title":"Epithelial cell adhesion molecule expression (CD326) in cancer: a short review","volume":"38","author":"Patriarca","year":"2012","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.humpath.2016.02.022_bb0070","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.bbamem.2013.04.018","article-title":"EpCAM: structure and function in health and disease","volume":"1828","author":"Schnell","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.humpath.2016.02.022_bb0075","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.humpath.2003.08.026","article-title":"Frequent EpCam protein expression in human carcinomas","volume":"35","author":"Went","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0080","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1245\/s10434-007-9393-9","article-title":"Prognostic value of circulating tumor markers in patients with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"14","author":"Baratti","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0085","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00268-013-1988-7","article-title":"Preoperative carcinoembryonic antigen level predicts prognosis in patients with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"37","author":"Canbay","year":"2013","journal-title":"World J Surg"},{"key":"10.1016\/j.humpath.2016.02.022_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004347-199701000-00001","article-title":"Immunohistochemical evidence supporting the appendiceal origin of pseudomyxoma peritonei in women","volume":"16","author":"Ronnett","year":"1997","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0095","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/sj.bjc.6603398","article-title":"A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei","volume":"95","author":"Bibi","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0100","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.humpath.2009.12.013","article-title":"Exploring the peritoneal surface malignancy phenotype\u2013a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models","volume":"41","author":"Flatmark","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0105","series-title":"WHO classification of tumours of the digestive system","first-page":"122","article-title":"Adenocarcinoma of the appendix","author":"Carr","year":"2010"},{"key":"10.1016\/j.humpath.2016.02.022_bb0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/07853890310020851","article-title":"Carcinomatosis from gastrointestinal cancer","volume":"36","author":"Sugarbaker","year":"2004","journal-title":"Ann Med"},{"key":"10.1016\/j.humpath.2016.02.022_bb0115","doi-asserted-by":"crossref","first-page":"E282","DOI":"10.1002\/ijc.29245","article-title":"Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry","volume":"136","author":"Nummela","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0120","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.humpath.2014.08.018","article-title":"Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma","volume":"46","author":"Thiel","year":"2015","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1365-2184.1999.32230079.x","article-title":"The role of the E-cadherin complex in gastrointestinal cell differentiation","volume":"32","author":"Del Buono","year":"1999","journal-title":"Cell Prolif"},{"key":"10.1016\/j.humpath.2016.02.022_bb0130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/15419061.2013.854778","article-title":"Signaling and mechanical roles of E-cadherin","volume":"20","author":"Bhatt","year":"2013","journal-title":"Cell Commun Adhes"},{"issue":"20 Suppl.","key":"10.1016\/j.humpath.2016.02.022_bb0135","doi-asserted-by":"crossref","first-page":"677","DOI":"10.5761\/atcs.cr.13-00260","article-title":"Primary pulmonary mucinous (colloid) adenocarcinoma with postoperative bone metastasis","author":"Morita","year":"2014","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"10.1016\/j.humpath.2016.02.022_bb0140","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/bjc.1986.191","article-title":"Prognostic significance of CEA immunoreactivity patterns in large bowel carcinoma tissue","volume":"54","author":"Wiggers","year":"1986","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0145","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/1097-0142(19820515)49:10<2077::AID-CNCR2820491020>3.0.CO;2-X","article-title":"Ultrastructural localization of carcinoembryonic antigen in normal intestine and colon cancer: abnormal distribution of CEA on the surfaces of colon cancer cells","volume":"49","author":"Ahnen","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0150","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00000478-200305000-00002","volume":"27","author":"Adsay","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0155","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.humpath.2014.03.007","article-title":"Significance of signet ring cells in high-grade mucinous adenocarcinoma of the peritoneum from appendiceal origin","volume":"45","author":"Sirintrapun","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0160","first-page":"4481","article-title":"Novel treatment strategies for cancer and their tumor-targeting approaches using antibodies against tumor-associated antigens","volume":"34","author":"Kuroki","year":"2014","journal-title":"Anticancer Res"},{"key":"10.1016\/j.humpath.2016.02.022_bb0165","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.3748\/wjg.v17.i30.3531","article-title":"Histological origin of pseudomyxoma peritonei in Chinese women: clinicopathology and immunohistochemistry","volume":"17","author":"Guo","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00004347-198303000-00005","article-title":"Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125","volume":"2","author":"Kabawat","year":"1983","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2016.02.022_bb0175","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/IGC.0b013e3181e37a54","article-title":"Intraperitoneal catheter leads to prolongation of the time to normalization of serum CA125 levels","volume":"20","author":"Richard","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0180","first-page":"407","article-title":"Temporary elevation of CA 125 after abdominal surgical treatment for benign disease and cancer","volume":"168","author":"Talbot","year":"1989","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.humpath.2016.02.022_bb0185","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/codi.12924","article-title":"Elevated tumour markers are normalized in most patients with pseudomyxoma peritonei one week after complete tumour removal","volume":"17","author":"Di Fabio","year":"2015","journal-title":"Color Dis"},{"key":"10.1016\/j.humpath.2016.02.022_bb0190","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/ijc.28158","article-title":"Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies","volume":"133","author":"Flatmark","year":"2013","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0195","doi-asserted-by":"crossref","first-page":"309","DOI":"10.7150\/jca.2.309","article-title":"Novel monoclonal antibodies for cancer treatment: the trifunctional antibody catumaxomab (removab)","volume":"2","author":"Seimetz","year":"2011","journal-title":"J Cancer"},{"key":"10.1016\/j.humpath.2016.02.022_bb0200","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000324667","article-title":"Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer: an open-label, multicenter, phase I\/II trial","volume":"34","author":"Str\u00f6hlein","year":"2011","journal-title":"Onkologie"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716300053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716300053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T01:24:02Z","timestamp":1600392242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817716300053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":40,"alternative-id":["S0046817716300053"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2016.02.022","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2016.02.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}