{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:45:35Z","timestamp":1789623935012,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.humpath.2016.04.015","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T04:41:42Z","timestamp":1463200902000},"page":"72-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Genomic copy number alterations in 33 malignant peritoneal mesothelioma analyzed by comparative genomic hybridization array"],"prefix":"10.1016","volume":"55","author":[{"given":"Pierre","family":"Chirac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Maillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lepr\u00eatre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Isaac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Glehen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Figeac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Villeneuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"P\u00e9ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Galateau-Sall\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-No\u00ebl","family":"Gilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Brevet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2016.04.015_bb0005","first-page":"47","article-title":"Mandatory notification of mesotheliomas in France: main results, 2012\u20132013","volume":"3\u20134","author":"Gallot","year":"2015","journal-title":"Bull Epid\u00e9miol Hebd"},{"issue":"9","key":"10.1016\/j.humpath.2016.04.015_bb0010","first-page":"32","article-title":"Peritoneal mesothelioma: a review","volume":"10","author":"Bridda","year":"2007","journal-title":"MedGenMed"},{"key":"10.1016\/j.humpath.2016.04.015_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00432-008-0444-9","article-title":"Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors","volume":"135","author":"Weiner","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0020","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/annonc\/mdl345","article-title":"Epidemiology of peritoneal mesothelioma: a review","volume":"18","author":"Boffetta","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0025","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/annonc\/mdr477","article-title":"Peritoneal surface malignancy group. Importance of gender in diffuse malignant peritoneal mesothelioma","volume":"23","author":"Cao","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0030","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/modpathol.2009.180","article-title":"Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases","volume":"23","author":"Klebe","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0035","first-page":"2108","article-title":"Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas","volume":"9","author":"Illei","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2016.04.015_bb0040","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.855","article-title":"The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma","volume":"43","author":"Bott","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2016.04.015_bb0045","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/ng.912","article-title":"Germline BAP1 mutations predispose to malignant mesothelioma","volume":"43","author":"Testa","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2016.04.015_bb0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0165-4608(01)00432-0","article-title":"Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Mesothelioma","volume":"127","author":"Sandberg","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.humpath.2016.04.015_bb0055","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/path.1128","article-title":"Molecular cytogenetic differences between histological subtypes of malignant mesotheliomas: DNA cytometry and comparative genomic hybridization of 90 cases","volume":"197","author":"Krismann","year":"2002","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0060","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1349-7006.2006.00386.x","article-title":"Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32","volume":"98","author":"Taniguchi","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1016\/j.humpath.2016.04.015_bb0065","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000109618","article-title":"Gene copy number analysis in malignant pleural mesothelioma using oligonucleotide array CGH","volume":"119","author":"Lindholm","year":"2007","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.humpath.2016.04.015_bb0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cancergen.2013.04.006","article-title":"Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines","volume":"206","author":"Klorin","year":"2013","journal-title":"Cancer Genet"},{"key":"10.1016\/j.humpath.2016.04.015_bb0075","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1158\/0008-5472.CAN-14-1008","article-title":"Whole-Exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma","volume":"75","author":"Guo","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2016.04.015_bb0080","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1440-1827.2009.02387.x","article-title":"Characterization of a complex chromosome aberration in two cases of peritoneal mesothelioma arising primarily in the hernial sac","volume":"59","author":"Serio","year":"2009","journal-title":"Pathol Int"},{"key":"10.1016\/j.humpath.2016.04.015_bb0085","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12967-015-0485-1","article-title":"BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma","volume":"13","author":"Alakus","year":"2015","journal-title":"J Transl Med"},{"key":"10.1016\/j.humpath.2016.04.015_bb0090","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/modpathol.2008.45","article-title":"Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas","volume":"21","author":"Chiosea","year":"2008","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0095","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/MPH.0000000000000262","article-title":"Malignant peritoneal mesothelioma in an adolescent male with BAP1 deletion","volume":"37","author":"Taylor","year":"2014","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0100","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.cancergen.2012.08.005","article-title":"Heterozygous loss of NF2 is an early molecular alteration in well-differentiated papillary mesothelioma of the peritoneum","volume":"205","author":"Nemoto","year":"2012","journal-title":"Cancer Genet"},{"key":"10.1016\/j.humpath.2016.04.015_bb0105","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1245\/ASO.2006.05.041","article-title":"Peritoneal mesothelioma treated by cytoreductive surgery and intraperitoneal hyperthermic chemotherapy: results of a prospective study","volume":"13","author":"Brigand","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.annpat.2014.01.008","article-title":"The RENAPE network: towards a new healthcare organization for the treatment of rare tumors of the peritoneum. Description of the network and role of the pathologists","volume":"34","author":"Villeneuve","year":"2014","journal-title":"Ann Pathol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0115","doi-asserted-by":"crossref","first-page":"647","DOI":"10.5858\/arpa.2012-0214-OA","article-title":"International mesothelioma interest group. Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the international mesothelioma interest group","volume":"137","author":"Husain","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2016.04.015_bb0120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.annpat.2014.01.009","article-title":"Gilg Soit Ilg a, Le Stang N et al. [the French mesothelioma network from 1998 to 2013]","volume":"34","author":"Galateau-Sall\u00e9","year":"2014","journal-title":"Ann Pathol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0125","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-1-4613-1247-5_23","article-title":"Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis","volume":"82","author":"Jacquet","year":"1996","journal-title":"Cancer Treat Res"},{"key":"10.1016\/j.humpath.2016.04.015_bb0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-7800-2-3","article-title":"Prognostic indicators in peritoneal carcinomatosis from gastrointestinal cancer","volume":"2","author":"Harmon","year":"2005","journal-title":"Int Semin Surg Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0135","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1093\/nar\/gkp1215","article-title":"Waved aCGH: to smooth or not to smooth","volume":"38","author":"Lepretre","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.humpath.2016.04.015_bb0140","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.molmed.2015.01.003","article-title":"Disease implications of the hippo\/YAP pathway","volume":"21","author":"Plouffe","year":"2015","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.humpath.2016.04.015_bb0145","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/(SICI)1097-4652(199908)180:2<150::AID-JCP2>3.0.CO;2-H","article-title":"Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma","volume":"180","author":"Murthy","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lungcan.2009.03.018","article-title":"p16INK4A inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos","volume":"67","author":"Andujar","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.humpath.2016.04.015_bb0155","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.ajpath.2010.10.039","article-title":"Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma","volume":"178","author":"Jean","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0160","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1042\/bj3570551","article-title":"Human cyritestin genes (CYRN1 and CYRN2) are non-functional","volume":"357","author":"Grzmil","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.humpath.2016.04.015_bb0165","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/neuonc\/noq158","article-title":"Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas","volume":"13","author":"Barrow","year":"2011","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0170","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12032-014-0071-z","article-title":"High-resolution genome-wide analysis identified recurrent genetic alterations in NK\/T-cell lymphoma, nasal type, which are associated with disease progression","volume":"31","author":"Sun","year":"2014","journal-title":"Med Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0175","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/ijc.28502","article-title":"COUP-TFII in pancreatic adenocarcinoma: clinical implication for patient survival and tumor progression","volume":"134","author":"Polvani","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2016.04.015_bb0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.gde.2006.12.007","article-title":"The many ways of Wnt in cancer","volume":"17","author":"Polakis","year":"2007","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.humpath.2016.04.015_bb0185","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1158\/0008-5472.CAN-04-0115","article-title":"Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells","volume":"64","author":"You","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2016.04.015_bb0190","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/dc.20281","article-title":"The expression pattern of beta-catenin in mesothelial proliferative lesions and its diagnostic utilities","volume":"33","author":"Dai","year":"2005","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.clcc.2015.02.001","article-title":"Development of small molecules targeting the Wnt signaling pathway in cancer stem cells for the treatment of colorectal cancer","volume":"14","author":"Song","year":"2015","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.humpath.2016.04.015_bb0200","doi-asserted-by":"crossref","first-page":"e2900","DOI":"10.1073\/pnas.1503500112","article-title":"VEGFB promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients","volume":"112","author":"Yang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2016.04.015_bb0205","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1245\/s10434-015-4644-7","article-title":"Intraperitoneal vascular endothelial growth factor: a prognostic factor and the potential for Intraperitoneal Bevacizumab use in peritoneal surface malignancies","volume":"22","author":"Chia","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.humpath.2016.04.015_bb0210","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(15)01238-6","article-title":"French cooperative thoracic intergroup (IFCT). Bevacizumab for newly diagnosed pleural mesothelioma in the mesothelioma Avastin Cisplatin Pemetrexed study (MAPS): a randomised, controlled, open-label, phase 3 trial","volume":"387","author":"Zalcman","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.humpath.2016.04.015_bb0215","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1517\/14712590802666397","article-title":"Aflibercept (AVE0005): an alternative strategy for inhibiting tumor angiogenesis by vascular endothelial growth factors","volume":"9","author":"Chu","year":"2009","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.humpath.2016.04.015_bb0220","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1200\/JCO.2012.42.8201","article-title":"Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen","volume":"30","author":"Van Cutsem","year":"2012","journal-title":"J Clin Oncol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716300648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716300648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T01:51:24Z","timestamp":1536717084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817716300648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":44,"alternative-id":["S0046817716300648"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2016.04.015","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic copy number alterations in 33 malignant peritoneal mesothelioma analyzed by comparative genomic hybridization array","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2016.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}