{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:38:29Z","timestamp":1791517109006,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.humpath.2016.04.019","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T00:39:52Z","timestamp":1463186392000},"page":"108-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Hodgkin lymphoma variant of Richter transformation: morphology, Epstein-Barr virus status, clonality, and survival analysis\u2014with comparison to Hodgkin-like lesion"],"prefix":"10.1016","volume":"55","author":[{"given":"Wenbin","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne W.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Sorbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Davies-Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Raffeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2016.04.019_bb0005","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/cncr.20773","article-title":"Richter syndrome: biology, incidence, and therapeutic strategies","volume":"103","author":"Tsimberidou","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2016.04.019_bb0010","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/j.seminoncol.2006.01.016","article-title":"Richter's transformation in chronic lymphocytic leukemia","volume":"33","author":"Tsimberidou","year":"2006","journal-title":"Semin Oncol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1320-5463.2003.01455.x","article-title":"Richter syndrome in B-cell chronic lymphocytic leukemia","volume":"53","author":"Nakamura","year":"2003","journal-title":"Pathol Int"},{"key":"10.1016\/j.humpath.2016.04.019_bb0020","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1182\/blood-2010-09-302174","article-title":"The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation","volume":"117","author":"Rossi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2016.04.019_bb0025","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ajh.10300","article-title":"Partially successful treatment of a patient with chronic lymphocytic leukemia and Hodgkin's disease: case report and literature review","volume":"72","author":"Adiga","year":"2003","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0030","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2141.2011.08907.x","article-title":"Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literature","volume":"156","author":"Bockorny","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/ajh.23939","article-title":"Hodgkin transformation of chronic lymphocytic leukemia: incidence, outcomes, and comparison to de novo Hodgkin lymphoma","volume":"90","author":"Parikh","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0040","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00000478-200405000-00018","article-title":"Distinct clonal origin in two cases of Hodgkin's lymphoma variant of Richter's syndrome associated with EBV infection","volume":"28","author":"de Leval","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0045","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1182\/blood.V91.5.1757","article-title":"Origin of the Hodgkin\/Reed-Sternberg cells in chronic lymphocytic leukemia with \u201cHodgkin's transformation\u201d","volume":"91","author":"Ohno","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2016.04.019_bb0050","doi-asserted-by":"crossref","first-page":"e435","DOI":"10.1016\/S1470-2045(14)70153-6","article-title":"Pathogenesis, diagnosis, and treatment of composite lymphomas","volume":"15","author":"Kuppers","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0055","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1097\/PAS.0b013e31804bdaf8","article-title":"IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution","volume":"31","author":"Mao","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0060","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00000478-199209000-00004","article-title":"Chronic lymphocytic leukemia\/small lymphocytic lymphoma with Reed-Sternberg\u2013like cells and possible transformation to Hodgkin's disease. Mediation by Epstein-Barr virus","volume":"16","author":"Momose","year":"1992","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0065","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1046\/j.1365-2141.1999.01765.x","article-title":"The immunosuppression and potential for EBV reactivation of fludarabine combined with cyclophosphamide and dexamethasone in patients with lymphoproliferative disorders","volume":"107","author":"Lazzarino","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0070","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.leukres.2004.09.008","article-title":"Richter's transformation of chronic lymphocytic leukemia. The possible role of fludarabine and the Epstein-Barr virus in its pathogenesis","volume":"29","author":"Thornton","year":"2005","journal-title":"Leuk Res"},{"key":"10.1016\/j.humpath.2016.04.019_bb0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2141.2005.05426.x","article-title":"Hodgkin's disease variant of Richter's syndrome in chronic lymphocytic leukaemia patients previously treated with fludarabine","volume":"129","author":"Fong","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0080","first-page":"91","article-title":"Richter's transformation of chronic lymphocytic leukemia with Hodgkin's-like cells is associated with Epstein-Barr virus infection","volume":"7","author":"Rubin","year":"1994","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0085","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V95.3.1023.003k07_1023_1031","article-title":"Hodgkin and Reed-Sternberg\u2013like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell\u2013derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease","volume":"95","author":"Kanzler","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2016.04.019_bb0090","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF03402211","article-title":"Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL","volume":"7","author":"Kuppers","year":"2001","journal-title":"Mol Med"},{"key":"10.1016\/j.humpath.2016.04.019_bb0095","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s004280000214","article-title":"Hodgkin\/Reed-Sternberg cells and Hodgkin's disease in patients with B-cell chronic lymphocytic leukaemia: an immunohistological, molecular and clinical study of four cases suggesting a heterogeneous pathogenetic background","volume":"437","author":"Pescarmona","year":"2000","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2016.04.019_bb0100","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1182\/blood.V100.4.1425.h81602001425_1425_1429","article-title":"Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma","volume":"100","author":"van den Berg","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2016.04.019_bb0105","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1097\/00000478-200211000-00008","article-title":"T-cell\/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells","volume":"26","author":"Lim","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0110","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/0046-8177(94)90085-X","article-title":"Optimal primer selection for clonality assessment by polymerase chain reaction analysis: II. Follicular lymphomas","volume":"25","author":"Segal","year":"1994","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0115","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00000478-200304000-00014","article-title":"Marginal zone B-cell lymphoma in children and young adults","volume":"27","author":"Taddesse-Heath","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0120","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","article-title":"Chronic lymphocytic leukemia","volume":"352","author":"Chiorazzi","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2016.04.019_bb0125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/path.1727","article-title":"Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms","volume":"205","author":"Carreras","year":"2005","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0130","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2002-10-3306","article-title":"ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile","volume":"101","author":"Wiestner","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2016.04.019_bb0135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00000478-199101000-00004","article-title":"Chronic lymphocytic leukemia with coexistent Hodgkin's disease: implications for the origin of the Reed-Sternberg cell","volume":"15","author":"Williams","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0140","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1182\/blood-2015-05-646935","article-title":"Integration of innate into adaptive immune responses in ZAP-70\u2013positive chronic lymphocytic leukemia","volume":"127","author":"Wagner","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2016.04.019_bb0145","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1053\/j.seminoncol.2006.01.009","article-title":"The origin of B-cell chronic lymphocytic leukemia","volume":"33","author":"Ghia","year":"2006","journal-title":"Semin Oncol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0150","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev.immunol.16.1.471","article-title":"The origin of Hodgkin and Reed\/Sternberg cells in Hodgkin's disease","volume":"16","author":"Kuppers","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0155","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/modpathol.3800145","article-title":"Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma","volume":"17","author":"Admirand","year":"2004","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0160","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/ijc.21716","article-title":"Molecular biology of Hodgkin's and Reed\/Sternberg cells in Hodgkin's lymphoma","volume":"118","author":"Brauninger","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2016.04.019_bb0165","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2141.2012.09127.x","article-title":"Poor prognosis of Hodgkin variant of Richter transformation in chronic lymphocytic leukemia treated with cladribine","volume":"158","author":"Jamroziak","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0170","first-page":"785","article-title":"Hodgkin's variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL study group","volume":"34","author":"Tadmor","year":"2014","journal-title":"Anticancer Res"},{"key":"10.1016\/j.humpath.2016.04.019_bb0175","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/1066896911406918","article-title":"Relevance of IgVH gene somatic hypermutation and interphase cytogenetics in lymphomatous presentation of chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"19","author":"Yeung","year":"2011","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.humpath.2016.04.019_bb0180","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1182\/blood-2002-11-3479","article-title":"Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma","volume":"101","author":"Walsh","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2016.04.019_bb0185","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/modpathol.3800677","article-title":"Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome","volume":"19","author":"Lai","year":"2006","journal-title":"Mod Pathol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716300685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817716300685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T17:00:38Z","timestamp":1600534838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817716300685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":37,"alternative-id":["S0046817716300685"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2016.04.019","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hodgkin lymphoma variant of Richter transformation: morphology, Epstein-Barr virus status, clonality, and survival analysis\u2014with comparison to Hodgkin-like lesion","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2016.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}