{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:52:21Z","timestamp":1790722341168,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.humpath.2016.07.019","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T14:24:21Z","timestamp":1470320661000},"page":"62-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-4064","authenticated-orcid":false,"given":"Natacha","family":"Kadlub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Sessiecq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Dainese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Lehalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Marlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Badoual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Galmiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Majoufre-Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Berdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Paule","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vianney","family":"Descroix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie E.","family":"Coudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.humpath.2016.07.019_bb0005","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1750-1172-7-S1-S6","article-title":"Cherubism: best clinical practice","volume":"7","author":"Papadaki","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.humpath.2016.07.019_bb0010","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1302\/0301-620X.32B3.334","article-title":"Cherubism\u2014familial fibrous dysplasia of the jaws","volume":"32","author":"Jones","year":"1950","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.humpath.2016.07.019_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0007-117X(78)80055-9","article-title":"Cherubism: a report of three cases","volume":"16","author":"Wayman","year":"1978","journal-title":"Br J Oral Surg"},{"key":"10.1016\/j.humpath.2016.07.019_bb0020","first-page":"589","article-title":"Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors","volume":"15","author":"Wang","year":"2006","journal-title":"Oncol Rep"},{"key":"10.1016\/j.humpath.2016.07.019_bb0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/88832","article-title":"Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism","volume":"28","author":"Ueki","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2016.07.019_bb0030","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1086\/302456","article-title":"The gene for cherubism maps to chromosome 4p16","volume":"65","author":"Tiziani","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humpath.2016.07.019_bb0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1086\/302454","article-title":"The gene for cherubism maps to chromosome 4p16.3","volume":"65","author":"Mangion","year":"1999","journal-title":"Am J Hum Genet"},{"issue":"Suppl. 1","key":"10.1016\/j.humpath.2016.07.019_bb0040","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1750-1172-7-S1-S5","article-title":"The role of SH3BP2 in the pathophysiology of cherubism","volume":"7","author":"Reichenberger","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.humpath.2016.07.019_bb0045","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI71081","article-title":"Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages","volume":"125","author":"Prod'Homme","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2016.07.019_bb0050","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cell.2006.10.047","article-title":"Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 cherubism mice","volume":"128","author":"Ueki","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2016.07.019_bb0055","doi-asserted-by":"crossref","first-page":"20952","DOI":"10.1074\/jbc.M109.091124","article-title":"3BP2 adapter protein is required for receptor activator of NF\u03baB ligand (RANKL)\u2013induced osteoclast differentiation of RAW264.7 cells","volume":"285","author":"Guez Guez","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2016.07.019_bb0060","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"6","author":"Takayanagi","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.humpath.2016.07.019_bb0065","doi-asserted-by":"crossref","first-page":"13984","DOI":"10.1074\/jbc.M213067200","article-title":"The calcineurin\/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells","volume":"14","author":"Hirotani","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2016.07.019_bb0070","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbrc.2008.04.080","article-title":"SH3BP2 is an activator of NFAT activity and osteoclastogenesis","volume":"371","author":"Lietman","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.humpath.2016.07.019_bb0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0300-9785(72)80043-7","article-title":"Cherubism","volume":"1","author":"Von Wowern","year":"1972","journal-title":"Int J Oral Surg"},{"key":"10.1016\/j.humpath.2016.07.019_bb0080","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/ppul.22686","article-title":"Nocturnal mouthpiece ventilation and medical hypnosis to treat severe obstructive sleep apnea in a child with cherubism","volume":"48","author":"Khirani","year":"2013","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.humpath.2016.07.019_bb0085","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0165-5876(03)00179-4","article-title":"Clinical and radiological evaluation of cherubism: a sporadic case report and review of the literature","volume":"67","author":"Ozkan","year":"2003","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.humpath.2016.07.019_bb0090","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/1097-0142(196905)23:5<1133::AID-CNCR2820230519>3.0.CO;2-Q","article-title":"Cherubism: an analysis of treatment","volume":"23","author":"Hamner","year":"1969","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2016.07.019_bb0095","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1054\/bjps.2001.3701","article-title":"Cherubism and its charlatans","volume":"54","author":"Lannon","year":"2001","journal-title":"Br J Plast Surg"},{"key":"10.1016\/j.humpath.2016.07.019_bb0100","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/jbmr.2431","article-title":"The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism","volume":"30","author":"Kadlub","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.humpath.2016.07.019_bb0105","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S0278-2391(98)90618-8","article-title":"Treatment of cherubism with locally aggressive behavior presenting in adulthood: report of four cases and a proposed new grading system","volume":"11","author":"Kalantar Motamedi","year":"1998","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.humpath.2016.07.019_bb0110","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/01.sap.0000248141.36904.19","article-title":"Two-stage surgical treatment of severe cherubism","volume":"58","author":"Raposo-Amaral","year":"2007","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.humpath.2016.07.019_bb0115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/humu.9433","article-title":"Identification of a novel mutation of SH3BP2 in cherubism and demonstration that SH3BP2 mutations lead to increased NFAT activation","volume":"27","author":"Lietman","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.humpath.2016.07.019_bb0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00315128","article-title":"Cytoplasmic vacuoles and bodies of the osteoclast. An electron microscope study","volume":"135","author":"Lucht","year":"1972","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"10.1016\/j.humpath.2016.07.019_bb0125","series-title":"Histological Typing of Odontogenic Tumours","first-page":"8","author":"Kramer","year":"1992"},{"key":"10.1016\/j.humpath.2016.07.019_bb0130","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.joms.2006.02.003","article-title":"Cherubism: a clinical, radiographic, and histopathologic comparison of 7 cases","volume":"64","author":"Pe\u00f1arrocha","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.humpath.2016.07.019_bb0135","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.joms.2006.05.061","article-title":"Cherubism: clinicoradiographic features, treatment, and long-term follow-up of 8 cases","volume":"65","author":"Carvalho Silva","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.humpath.2016.07.019_bb0140","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.febslet.2009.06.047","article-title":"Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation","volume":"583","author":"Song","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1016\/j.humpath.2016.07.019_bb0145","first-page":"204","article-title":"Osteoclastogenesis\u2014current knowledge and future perspectives","volume":"8","author":"Yavropoulou","year":"2008","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.humpath.2016.07.019_bb0150","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-0714.2009.00855.x","article-title":"NFATc1 and TNF alpha expression in giant cell lesions of the jaws","volume":"3","author":"Amaral","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.humpath.2016.07.019_bb0155","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1600-0714.2010.00944.x","article-title":"A comparative immunohistochemical evaluation of CD68 and TRAP protein expression in central and peripheral giant cell granulomas of the jaws","volume":"40","author":"Torabinia","year":"2011","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.humpath.2016.07.019_bb0160","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3892\/ol.2011.274","article-title":"Increased expression of NFATc1 in giant cell lesions of the jaws, cherubism and brown tumor of hyperparathyroidism","volume":"2","author":"Duarte","year":"2011","journal-title":"Oncol Lett"},{"key":"10.1016\/j.humpath.2016.07.019_bb0165","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1002\/jbmr.2295","article-title":"SH3BP2 cherubism mutation potentiates TNF-\u03b1\u2013induced osteoclastogenesis via NFATc1 and TNF-\u03b1-mediated inflammatory bone loss","volume":"29","author":"Mukai","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.humpath.2016.07.019_bb0170","first-page":"147","article-title":"Ineffectiveness of tumor necrosis factor-alpha inhibition in association with bisphosphonates for the treatment of cherubism","volume":"29","author":"Pagnini","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.humpath.2016.07.019_bb0175","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bone.2012.10.003","article-title":"Anti-tumor necrosis factor treatment in cherubism\u2014clinical, radiological and histological findings in two children","volume":"52","author":"Hero","year":"2013","journal-title":"Bone"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681771630171X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681771630171X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T01:00:52Z","timestamp":1568250052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004681771630171X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":35,"alternative-id":["S004681771630171X"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2016.07.019","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2016.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}