{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:48:17Z","timestamp":1790174897920,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.humpath.2016.12.023","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T01:04:45Z","timestamp":1484096685000},"page":"115-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Phospholipase D messenger RNA expression and clinical role in high-grade serous carcinoma"],"prefix":"10.1016","volume":"62","author":[{"given":"Keren","family":"Harel-Dassa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Yedgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes G.","family":"Trop\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2016.12.023_bb0005","first-page":"845","article-title":"Phospholipase D in endocytosis and endosomal recycling pathways","volume":"2009","author":"Donaldson","year":"1791","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.humpath.2016.12.023_bb0010","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0960-9822(97)70090-3","article-title":"Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization","volume":"7","author":"Colley","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.humpath.2016.12.023_bb0015","doi-asserted-by":"publisher","first-page":"e55325","DOI":"10.1371\/journal.pone.0055325","article-title":"Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment","volume":"8","author":"Ali","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2016.12.023_bb0020","doi-asserted-by":"publisher","first-page":"21746","DOI":"10.1074\/jbc.M702968200","article-title":"Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage","volume":"282","author":"Zeniou-Meyer","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2016.12.023_bb0025","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/ncb1594","article-title":"Phospholipase D2\u2013generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos","volume":"9","author":"Zhao","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.humpath.2016.12.023_bb0030","first-page":"949","article-title":"Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells","volume":"2009","author":"Foster","year":"1791","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.humpath.2016.12.023_bb0035","first-page":"856","article-title":"Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton","volume":"2009","author":"Rudge","year":"1791","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.humpath.2016.12.023_bb0040","first-page":"789","article-title":"Phospholipase D in cell proliferation and cancer","volume":"11","author":"Foster","year":"2003","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.humpath.2016.12.023_bb0045","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1126\/science.1170179","article-title":"Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis","volume":"324","author":"Nishikimi","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.humpath.2016.12.023_bb0050","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1158\/0008-5472.CAN-10-2463","article-title":"Phospholipase D meets Wnt signaling: a new target for cancer therapy","volume":"71","author":"Kang","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2016.12.023_bb0055","doi-asserted-by":"publisher","first-page":"29640","DOI":"10.1074\/jbc.270.50.29640","article-title":"Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family","volume":"270","author":"Hammond","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2016.12.023_bb0060","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0163-7258(02)00170-5","article-title":"Pharmacological importance of phospholipase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade","volume":"94","author":"Rizzo","year":"2002","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.humpath.2016.12.023_bb0065","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0304-3835(00)00612-1","article-title":"Overexpression of phospholipase D1 in human breast cancer tissues","volume":"161","author":"Noh","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2016.12.023_bb0070","doi-asserted-by":"publisher","first-page":"18991","DOI":"10.1074\/jbc.M110.111542","article-title":"Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function","volume":"285","author":"Tabatabaian","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2016.12.023_bb0075","doi-asserted-by":"publisher","first-page":"22557","DOI":"10.1074\/jbc.R114.574152","article-title":"Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis","volume":"289","author":"Gomez-Cambronero","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2016.12.023_bb0080","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1194\/jlr.M300188-JLR200","article-title":"Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells","volume":"44","author":"Luquain","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.humpath.2016.12.023_bb0085","first-page":"2482","article-title":"Constitutive and lysophosphatidic acid (LPA)\u2013induced LPA production: role of phospholipase D and phospholipase A2","volume":"6","author":"Eder","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2016.12.023_bb0090","series-title":"Serous effusions","year":"2011"},{"key":"10.1016\/j.humpath.2016.12.023_bb0095","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/sj.leu.2402880","article-title":"Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies","volume":"17","author":"Lossos","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2016.12.023_bb0100","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.4161\/cc.6.22.4921","article-title":"Suppression of TGF-beta signaling by phospholipase D","volume":"6","author":"Gadir","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.humpath.2016.12.023_bb0105","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1124\/mol.107.040105","article-title":"Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells","volume":"74","author":"Knoepp","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.humpath.2016.12.023_bb0110","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/carcin\/bgn287","article-title":"Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A\/NF-kappaB\/Sp1\u2013mediated signaling pathways","volume":"30","author":"Park","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.humpath.2016.12.023_bb0115","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/BF00133618","article-title":"Role of phospholipase D in laminin-induced production of gelatinase A (MMP-2) in metastatic cells","volume":"13","author":"Reich","year":"1995","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.humpath.2016.12.023_bb0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3727\/000000003108748586","article-title":"Increased activity and expression of phospholipase D2 in human colorectal cancer","volume":"14","author":"Oshimoto","year":"2003","journal-title":"Oncol Res"},{"key":"10.1016\/j.humpath.2016.12.023_bb0125","first-page":"134","article-title":"Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications","volume":"4","author":"Dhingra","year":"2010","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.humpath.2016.12.023_bb0130","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1007\/s13238-015-0187-8","article-title":"MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.humpath.2016.12.023_bb0135","first-page":"1329","article-title":"Expression of phospholipase D2 in human colorectal carcinoma","volume":"18","author":"Saito","year":"2007","journal-title":"Oncol Rep"},{"key":"10.1016\/j.humpath.2016.12.023_bb0140","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.humpath.2009.09.017","article-title":"Mammalian target of rapamycin is a biomarker of poor survival in metastatic serous ovarian carcinoma","volume":"41","author":"Bunkholt Elstrand","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2016.12.023_bb0145","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10585-010-9315-2","article-title":"Mesenchymal-to-epithelial transition determinants as characteristics of ovarian carcinoma effusions","volume":"27","author":"Elloul","year":"2010","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.humpath.2016.12.023_bb0150","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1038\/emm.2014.86","article-title":"Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid","volume":"46","author":"Han","year":"2014","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.humpath.2016.12.023_bb0155","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1586\/14737159.2016.1156532","article-title":"Recently identified drug resistance biomarkers in ovarian cancer","volume":"16","author":"Davidson","year":"2016","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.humpath.2016.12.023_bb0160","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.2741\/2811","article-title":"MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2","volume":"13","author":"Gorovetz","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.humpath.2016.12.023_bb0165","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.ygyno.2006.06.042","article-title":"The clinical role of phospholipase A2 isoforms in advanced-stage ovarian carcinoma","volume":"103","author":"Gorovetz","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.humpath.2016.12.023_bb0170","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nrd4099","article-title":"Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond","volume":"12","author":"Kunkel","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.humpath.2016.12.023_bb0175","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3109\/07357907.2013.876646","article-title":"Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy?","volume":"32","author":"Dai","year":"2014","journal-title":"Cancer Invest"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717300126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717300126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T07:14:56Z","timestamp":1568704496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817717300126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":35,"alternative-id":["S0046817717300126"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2016.12.023","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phospholipase D messenger RNA expression and clinical role in high-grade serous carcinoma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2016.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}