{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:16:27Z","timestamp":1781496987530,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.humpath.2017.08.004","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T03:45:29Z","timestamp":1503027929000},"page":"217-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Histopathological evidence of neoplastic progression of von Meyenburg complex to intrahepatic cholangiocarcinoma"],"prefix":"10.1016","volume":"67","author":[{"given":"Amarpreet","family":"Bhalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar W.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2094-0262","authenticated-orcid":false,"given":"Jingmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2017.08.004_bb0005","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jhep.2014.01.021","article-title":"Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma","volume":"60","author":"Bridgewater","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00535-013-0894-y","article-title":"New insights into the molecular pathogenesis of intrahepatic cholangiocarcinoma","volume":"49","author":"Patel","year":"2014","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0015","series-title":"WHO classification of Tumours of the digestive system","first-page":"217","article-title":"Intrahepatic cholangiocarcinoma","author":"Nakanuma","year":"2010"},{"key":"10.1016\/j.humpath.2017.08.004_bb0020","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00000441-190604000-00011","article-title":"Nonparasitic cysts (congenital) of the liver, with a study of aberrant bile ducts","volume":"131","author":"Moschcowitz","year":"1906","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.humpath.2017.08.004_bb0025","series-title":"Practical hepatic pathology: A diagnostic approach","first-page":"355","article-title":"Fibrocystic liver diseases","author":"Saxena","year":"2011"},{"key":"10.1016\/j.humpath.2017.08.004_bb0030","series-title":"MacSween's pathology of the liver","first-page":"761","article-title":"Tumors and tumor-like lesions of the liver","author":"Goodman","year":"2012"},{"key":"10.1016\/j.humpath.2017.08.004_bb0035","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/00000478-200008000-00011","article-title":"Evidence for the neoplastic transformation of von-Meyenburg complexes","volume":"24","author":"Jain","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0040","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/PAI.0000000000000132","article-title":"Malignant transformation in von-Meyenburg complexes: histologic and immunohistochemical clues with illustrative cases","volume":"23","author":"Parekh","year":"2015","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0045","doi-asserted-by":"crossref","first-page":"805973","DOI":"10.1155\/2014\/805973","article-title":"What are the precursor and early lesions of peripheral intrahepatic cholangiocarcinoma?","volume":"2014","author":"Nakanuma","year":"2014","journal-title":"Int J Hepatol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/PAI.0b013e3181b94fd8","article-title":"Molecular evidence for the neoplastic potential of hepatic von-Meyenburg complexes","volume":"18","author":"Jain","year":"2010","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0055","series-title":"WHO classification of tumours of the digestive system","author":"Bosman","year":"2010"},{"key":"10.1016\/j.humpath.2017.08.004_bb0060","first-page":"332","article-title":"Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator","volume":"3","author":"Graham","year":"1990","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0065","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1309\/AJCPWHUEFTGBWKE4","article-title":"Objective criteria for crohn-like lymphoid reaction in colorectal cancer","volume":"139","author":"Ueno","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0070","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/dc.23729","article-title":"The usefulness of adding p53 immunocytochemistry to bile drainage cytology for the diagnosis of malignant biliary strictures","volume":"45","author":"Yeo","year":"2017","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0075","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/PAS.0000000000000386","article-title":"Combined immunohistochemistry of PLK1, p21, and p53 for predicting TP53 status: an independent prognostic factor of breast cancer","volume":"39","author":"Watanabe","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0080","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.5858\/2000-124-1704-COIALW","article-title":"Cholangiocarcinoma occurring in a liver with multiple bile duct hamartomas (von Meyenburg complexes)","volume":"124","author":"Rocken","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2017.08.004_bb0085","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/PAS.0b013e31826e0249","article-title":"Intrahepatic cholangiocarcinoma with predominant \u201cductal plate malformation\" pattern: a new subtype","volume":"36","author":"Nakanuma","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0090","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/PAS.0b013e31802b34b6","article-title":"Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type","volume":"31","author":"Aishima","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0095","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2559.2007.02735.x","article-title":"A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: \u2018bile ductular carcinoma'","volume":"51","author":"Kozaka","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2017.08.004_bb0100","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/modpathol.2013.241","article-title":"Morphological subclassification of intrahepatic cholangiocarcinoma: etiological, clinicopathological, and molecular features","volume":"27","author":"Liau","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0105","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/PAS.0000000000000670","article-title":"Distinct clinicopathologic and genetic features of 2 histologic subtypes of intrahepatic cholangiocarcinoma","volume":"40","author":"Hayashi","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0110","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/jhbp.126","article-title":"Molecular mechanism of cholangiocarcinoma carcinogenesis","volume":"21","author":"Maemura","year":"2014","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.humpath.2017.08.004_bb0115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/jhbp.156","article-title":"Molecular diagnosis of intrahepatic cholangiocarcinoma","volume":"22","author":"Haga","year":"2015","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.humpath.2017.08.004_bb0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.canlet.2016.02.038","article-title":"Multiple cellular origins and molecular evolution of intrahepatic cholangiocarcinoma","volume":"379","author":"Wei","year":"2016","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2017.08.004_bb0125","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3748\/wjg.v22.i4.1335","article-title":"Molecular genetics and targeted therapeutics in biliary tract carcinoma","volume":"22","author":"Marks","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0130","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1245\/s10434-015-5046-6","article-title":"Cholangiocarcinoma heterogeneity revealed by multigene mutational profiling: clinical and prognostic relevance in surgically resected patients","volume":"23","author":"Ruzzenente","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0135","doi-asserted-by":"crossref","first-page":"179528","DOI":"10.1155\/2015\/179528","article-title":"An omics perspective on molecular biomarkers for diagnosis, prognosis, and therapeutics of cholangiocarcinoma","volume":"2015","author":"Seeree","year":"2015","journal-title":"Int J Genomics"},{"key":"10.1016\/j.humpath.2017.08.004_bb0140","first-page":"8068513","article-title":"Biliary adenofibroma with invasive carcinoma: case report and review of the literature","volume":"2016","author":"Godambe","year":"2016","journal-title":"Case Rep Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0145","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00000478-200305000-00014","article-title":"Biliary adenofibroma: a rare neoplasm of bile duct origin with an indolent behavior","volume":"27","author":"Varnholt","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0150","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2214\/ajr.179.1.1790280","article-title":"Biliary adenofibroma with malignant transformation and pulmonary metastases: CT findings","volume":"179","author":"Akin","year":"2002","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0155","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/PAS.0b013e3181ead722","article-title":"An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis","volume":"34","author":"Hughes","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.08.004_bb0160","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1158\/0008-5472.CAN-11-3596","article-title":"Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma","volume":"72","author":"O'Dell","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2017.08.004_bb0165","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/342705a0","article-title":"Mutations in the p53 gene occur in diverse human tumour types","volume":"342","author":"Nigro","year":"1989","journal-title":"Nature"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717302757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717302757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T10:41:20Z","timestamp":1659350480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817717302757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":33,"alternative-id":["S0046817717302757"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2017.08.004","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histopathological evidence of neoplastic progression of von Meyenburg complex to intrahepatic cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2017.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}