{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:10:03Z","timestamp":1777623003423,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 26870129"],"award-info":[{"award-number":["JP 26870129"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25460431"],"award-info":[{"award-number":["25460431"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.humpath.2017.09.009","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T08:17:47Z","timestamp":1506759467000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Fetal gut\u2013like differentiation in gallbladder cancer"],"prefix":"10.1016","volume":"70","author":[{"given":"Kei","family":"Koyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Narita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukitsugu","family":"Kudo-Asabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Sageshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nanjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiteru","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2017.09.009_bb0005","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12253-014-9886-3","article-title":"Pathology of gallbladder carcinoma: current understanding and new perspectives","volume":"21","author":"Bal","year":"2015","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.humpath.2017.09.009_bb0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1470-2045(03)01021-0","article-title":"Carcinoma of the gallbladder","volume":"4","author":"Misra","year":"2003","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0015","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1097\/PAS.0b013e3181706237","article-title":"Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases","volume":"32","author":"Albores-Saavedra","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.humpath.2016.09.008","article-title":"Poorly cohesive cell (diffuse-infiltrative\/signet ring cell) carcinomas of the gallbladder: clinicopathological analysis of 24 cases identified in 628 gallbladder carcinomas","volume":"60","author":"Tuncel","year":"2017","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00000478-199501000-00011","article-title":"Clear cell carcinomas of the gallbladder and extrahepatic bile ducts","volume":"19","author":"Vardaman","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0030","series-title":"WHO classification of tumors of the digestive system","author":"Bosman","year":"2010"},{"key":"10.1016\/j.humpath.2017.09.009_bb0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1365-2559.2005.02187.x","article-title":"Hepatoid adenocarcinoma of the gallbladder","volume":"47","author":"Sakamoto","year":"2005","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2017.09.009_bb0040","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/gut.48.4.558","article-title":"Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders","volume":"48","author":"Zhu","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2017.09.009_bb0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ijc.10856","article-title":"Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling","volume":"103","author":"Midorikawa","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2017.09.009_bb0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0006-291X(03)00908-2","article-title":"Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker","volume":"306","author":"Nakatsura","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.humpath.2017.09.009_bb0055","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1158\/0008-5472.CAN-03-2191","article-title":"Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma","volume":"64","author":"Hippo","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2017.09.009_bb0060","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/PAS.0b013e318198177d","article-title":"SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma","volume":"33","author":"Cao","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0065","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ncb1481","article-title":"Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1","volume":"8","author":"Zhang","year":"2006","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0070","doi-asserted-by":"crossref","first-page":"19756","DOI":"10.1073\/pnas.0809321105","article-title":"Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells","volume":"105","author":"Yang","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2017.09.009_bb0075","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/PAS.0000000000000116","article-title":"SALL4 expression in germ cell and non-germ cell tumors: a systematic immunohistochemical study of 3215 cases","volume":"38","author":"Miettinen","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0080","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/PAS.0b013e3181d1dcdd","article-title":"SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma","volume":"34","author":"Ushiku","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0085","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/modpathol.2009.40","article-title":"Glypican-3 expression in clear cell adenocarcinoma of the ovary","volume":"22","author":"Maeda","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0090","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1158\/1078-0432.CCR-04-0348","article-title":"Identification of glypican-3 as a novel tumor marker for melanoma","volume":"10","author":"Nakatsura","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2017.09.009_bb0095","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/his.12730","article-title":"Quantification of glypican 3, \u03b2-catenin and claudin-1 protein expression in hepatoblastoma and paediatric hepatocellular carcinoma by colour deconvolution","volume":"67","author":"Zhou","year":"2015","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2017.09.009_bb0100","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1349-7006.2009.01108.x","article-title":"Glypican 3-expressing gastric carcinoma: distinct subgroup unifying hepatoid, clear-cell, and alpha-fetoprotein-producing gastric carcinomas","volume":"100","author":"Ushiku","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.humpath.2017.09.009_bb0105","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/pin.12402","article-title":"A case of adenocarcinoma with enteroblastic differentiation of the ampulla of Vater","volume":"66","author":"Mitsuma","year":"2016","journal-title":"Pathol Int"},{"key":"10.1016\/j.humpath.2017.09.009_bb0110","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.humpath.2017.02.023","article-title":"An unusual primary malignant tumor of the stomach: fetal gut\u2013like gastric adenocarcinoma with \"blastoma\"-like component","volume":"67","author":"Taher","year":"2017","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0115","series-title":"Japanese classification of gastric carcinoma","author":"Japanese Gastric Cancer Association","year":"2010"},{"key":"10.1016\/j.humpath.2017.09.009_bb0120","first-page":"589","article-title":"A case of alpha-fetoprotein strongly positive cholecystic cancer associated with porcelain gallbladder (author's transl)","volume":"23","author":"Miyasaka","year":"1978","journal-title":"Rinsho Hoshasen"},{"key":"10.1016\/j.humpath.2017.09.009_bb0125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00795-013-0049-5","article-title":"Alpha-fetoprotein\u2013producing clear cell carcinoma of the gallbladder with neuroendocrine differentiation","volume":"47","author":"Sentani","year":"2014","journal-title":"Med Mol Morphol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0130","first-page":"ED09","article-title":"Hepatoid adenocarcinoma of the gall bladder-a rare variant","volume":"9","author":"Devi","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.humpath.2017.09.009_bb0135","first-page":"179","article-title":"Hepatoid carcinoma of the gallbladder","volume":"39","author":"Koswara","year":"2007","journal-title":"Acta Med Indones"},{"key":"10.1016\/j.humpath.2017.09.009_bb0140","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/BF02347628","article-title":"Alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9\u2013producing gallbladder cancer","volume":"31","author":"Ono","year":"1996","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0145","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/ng.3375","article-title":"Genomic spectra of biliary tract cancer","volume":"47","author":"Nakamura","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.humpath.2017.09.009_bb0150","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.anndiagpath.2010.10.004","article-title":"Expression and clinicopathologic significance of glypican 3 in hepatocellular carcinoma","volume":"15","author":"Yan","year":"2011","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.humpath.2017.09.009_bb0155","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3892\/ol.2016.4079","article-title":"Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma","volume":"11","author":"Luo","year":"2016","journal-title":"Oncol Lett"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717303544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717303544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T23:13:50Z","timestamp":1617837230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817717303544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":31,"alternative-id":["S0046817717303544"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2017.09.009","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal gut\u2013like differentiation in gallbladder cancer","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2017.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}