{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:17:19Z","timestamp":1792124239710,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.humpath.2017.12.018","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T17:51:41Z","timestamp":1515174701000},"page":"89-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Decreased expression of megalin and cubilin and altered mitochondrial activity in tenofovir nephrotoxicity"],"prefix":"10.1016","volume":"73","author":[{"given":"Alexandre","family":"Cez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Brocheriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Xavier","family":"Lescure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clovis","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Pialoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren K.","family":"Moestrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Fellahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ronco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Plaisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2017.12.018_bb0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/jama.292.2.191","article-title":"Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial","volume":"292","author":"Gallant","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.humpath.2017.12.018_bb0010","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMoa1506273","article-title":"On-demand preexposure prophylaxis in men at high risk for HIV-1 Infection","volume":"373","author":"Molina","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2017.12.018_bb0015","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1056\/NEJMoa0802878","article-title":"Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B","volume":"359","author":"Marcellin","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2017.12.018_bb0020","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1081\/NCN-100002341","article-title":"Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs","volume":"20","author":"Cihlar","year":"2001","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.humpath.2017.12.018_bb0025","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1128\/AAC.00251-06","article-title":"Mechanism of active renal tubular efflux of tenofovir","volume":"50","author":"Ray","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.humpath.2017.12.018_bb0030","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1097\/00002030-200206140-00008","article-title":"Tenofovir DF in antiretroviral-experienced patients: results from a 48-week, randomized, double-blind study","volume":"16","author":"Schooley","year":"2002","journal-title":"AIDS"},{"key":"10.1016\/j.humpath.2017.12.018_bb0035","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/ndt\/gfh658","article-title":"Long-term renal safety of tenofovir disoproxil fumarate in antiretroviral-naive HIV-1-infected patients. Data from a double-blind randomized active-controlled multicentre study","volume":"20","author":"Izzedine","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.humpath.2017.12.018_bb0040","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1086\/655681","article-title":"Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients","volume":"51","author":"Gallant","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.humpath.2017.12.018_bb0045","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1097\/QAD.0b013e328339fe53","article-title":"Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients","volume":"24","author":"Mocroft","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.humpath.2017.12.018_bb0050","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/QAD.0b013e328351f68f","article-title":"Association of tenofovir exposure with kidney disease risk in HIV infection","volume":"26","author":"Scherzer","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.humpath.2017.12.018_bb0055","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.2215\/CJN.09191010","article-title":"New AIDS data group: risk factors of chronic kidney disease in HIV-infected patients","volume":"6","author":"Flandre","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2017.12.018_bb0060","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/infdis\/jit043","article-title":"Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study","volume":"207","author":"Ryom","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humpath.2017.12.018_bb0065","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1053\/ajkd.2002.36924","article-title":"Fanconi syndrome and renal failure induced by tenofovir: a first case report","volume":"40","author":"Verhelst","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.humpath.2017.12.018_bb0070","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1086\/368314","article-title":"Tenofovir-related nephrotoxicity in human imunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus","volume":"36","author":"Karras","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.humpath.2017.12.018_bb0075","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00126334-200403010-00007","article-title":"Renal tubular dysfunction associated with tenofovir therapy. Report of 7 cases","volume":"35","author":"Peyri\u00e8re","year":"2004","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.humpath.2017.12.018_bb0080","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1086\/499048","article-title":"Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions","volume":"42","author":"Zimmermann","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.humpath.2017.12.018_bb0085","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ki.2010.318","article-title":"Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities","volume":"78","author":"Herlitz","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.humpath.2017.12.018_bb0090","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/QAD.0000000000000628","article-title":"Nonalbumin proteinuria predominates in biopsy-proven tenofovir nephrotoxicity","volume":"29","author":"Sise","year":"2015","journal-title":"AIDS"},{"key":"10.1016\/j.humpath.2017.12.018_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/kisup.2012.1","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.humpath.2017.12.018_bb0100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.ajkd.2010.03.010","article-title":"Immunoglobulin deposition disease with a membranous pattern and a circulating monoclonal immunoglobulin G with charge-dependent aggregation properties","volume":"56","author":"de Seigneux","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.humpath.2017.12.018_bb0105","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0091-679X(01)65019-2","article-title":"Optical imaging techniques (histochemical, immunohistochemical, and in situ hybridization staining methods) to visualize mitochondria","volume":"65","author":"Tanji","year":"2001","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.humpath.2017.12.018_bb0110","doi-asserted-by":"crossref","first-page":"930","DOI":"10.2215\/CJN.10051012","article-title":"Tubulointerstitial nephropathies in HIV-infected patients over the past 15 years: a clinico-pathological study","volume":"8","author":"Zaidan","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2017.12.018_bb0115","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/mol.106.028233","article-title":"Functional involvement of multidrug resistance-associated protein 4 (MRP4\/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir","volume":"71","author":"Imaoka","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.humpath.2017.12.018_bb0120","doi-asserted-by":"crossref","first-page":"567","DOI":"10.5414\/CNP71567","article-title":"Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction","volume":"71","author":"Morelle","year":"2009","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.humpath.2017.12.018_bb0125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1152\/physiol.00022.2012","article-title":"Endocytic receptors in the renal proximal tubule","volume":"27","author":"Christensen","year":"2012","journal-title":"Physiology"},{"key":"10.1016\/j.humpath.2017.12.018_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1681\/ASN.V131125","article-title":"Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome","volume":"13","author":"Norden","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.humpath.2017.12.018_bb0135","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1073\/pnas.1432873100","article-title":"Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules","volume":"100","author":"Christensen","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2017.12.018_bb0140","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1053\/j.ajkd.2008.03.010","article-title":"Urinary protein excretion pattern and renal expression of megalin and cubilin in nephropathic cystinosis","volume":"51","author":"Wilmer","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.humpath.2017.12.018_bb0145","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.1073\/pnas.1302063110","article-title":"Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients","volume":"110","author":"Gorvin","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2017.12.018_bb0150","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1093\/hmg\/ddt617","article-title":"Dedifferentiation and aberrations of the endolysosomal compartment characterize the early stage of nephropathic cystinosis","volume":"23","author":"Raggi","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.humpath.2017.12.018_bb0155","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1053\/hupa.2001.25586","article-title":"Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion","volume":"32","author":"Tanji","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2017.12.018_bb0160","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1128\/AAC.46.3.716-723.2002","article-title":"Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors","volume":"46","author":"Birkus","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.humpath.2017.12.018_bb0165","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/labinvest.2009.14","article-title":"Tenofovir renal toxicity targets mitochondria of renal proximal tubules","volume":"89","author":"Kohler","year":"2009","journal-title":"Lab Investig"},{"key":"10.1016\/j.humpath.2017.12.018_bb0170","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/QAI.0b013e3181a666eb","article-title":"Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats","volume":"51","author":"Lebrecht","year":"2009","journal-title":"J Acquir Immune Defic Syndr"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717304896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817717304896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T21:55:18Z","timestamp":1660254918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817717304896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":34,"alternative-id":["S0046817717304896"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2017.12.018","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased expression of megalin and cubilin and altered mitochondrial activity in tenofovir nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2017.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}