{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T10:16:31Z","timestamp":1776248191110,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672696"],"award-info":[{"award-number":["81672696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772912"],"award-info":[{"award-number":["81772912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["(7152033"],"award-info":[{"award-number":["(7152033"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Baiqianwan Talents Project"},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of special funding support","doi-asserted-by":"publisher","award":["ZYLX201603"],"award-info":[{"award-number":["ZYLX201603"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of special funding support","doi-asserted-by":"publisher","award":["Z151100003915074"],"award-info":[{"award-number":["Z151100003915074"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["humanpathol.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.humpath.2018.02.009","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T16:41:42Z","timestamp":1518540102000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Gene expression screening identifies CDCA5 as a potential therapeutic target in acral melanoma"],"prefix":"10.1016","volume":"75","author":[{"given":"Tianxiao","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sifan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanliang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2018.02.009_bb0005","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1056\/NEJMra041245","article-title":"Management of cutaneous melanoma","volume":"351","author":"Tsao","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2018.02.009_bb0010","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature05661","article-title":"Melanoma biology and new targeted therapy","volume":"445","author":"Gray-Schopfer","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2018.02.009_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/pcmr.12172","article-title":"Why is melanoma so metastatic","volume":"27","author":"Braeuer","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.humpath.2018.02.009_bb0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2407-11-85","article-title":"Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: a study of 522 consecutive cases","volume":"11","author":"Chi","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.humpath.2018.02.009_bb0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2018.02.009_bb0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejca.2011.06.056","article-title":"Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort","volume":"48","author":"Si","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.humpath.2018.02.009_bb0035","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1101\/gr.125591.111","article-title":"Whole genome sequencing of matched primary and metastatic acral melanomas","volume":"22","author":"Turajlic","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/j.humpath.2018.02.009_bb0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2018.02.009_bb0045","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa060992","article-title":"Sentinel-node biopsy or nodal observation in melanoma","volume":"355","author":"Morton","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2018.02.009_bb0050","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/modpathol.2012.32","article-title":"Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases","volume":"25","author":"Koh","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0055","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1158\/1078-0432.CCR-17-0070","article-title":"Frequent genetic aberrations in the CDK4 pathway in acral melanoma indicate the potential for CDK4\/6 inhibitors in targeted therapy","volume":"23","author":"Kong","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2018.02.009_bb0060","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/labinvest.3700303","article-title":"Reliable gene expression measurements from degraded RNA by quantitative real-time PCR depend on short amplicons and a proper normalization","volume":"85","author":"Antonov","year":"2005","journal-title":"Lab Investig"},{"key":"10.1016\/j.humpath.2018.02.009_bb0065","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1200\/JCO.2000.18.22.3782","article-title":"Prognostic factors in metastatic melanoma: a pooled analysis of Eastern Cooperative Oncology Group trials","volume":"18","author":"Manola","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0070","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1158\/1078-0432.CCR-05-2447","article-title":"Cutaneous melanoma subtypes show different BRAF and NRAS mutation frequencies","volume":"12","author":"Saldanha","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2018.02.009_bb0075","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1634\/theoncologist.2014-0468","article-title":"Clinical activity of ipilimumab in acral melanoma: a retrospective review","volume":"20","author":"Johnson","year":"2015","journal-title":"Oncologist"},{"key":"10.1016\/j.humpath.2018.02.009_bb0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jaad.2014.10.008","article-title":"Acral lentiginous melanoma: who benefits from sentinel lymph node biopsy","volume":"72","author":"Ito","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0085","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMoa1002011","article-title":"Inhibition of mutated, activated BRAF in metastatic melanoma","volume":"363","author":"Flaherty","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2018.02.009_bb0090","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1001\/jama.2011.746","article-title":"KIT as a therapeutic target in metastatic melanoma","volume":"305","author":"Carvajal","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.humpath.2018.02.009_bb0095","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1056\/NEJMoa1408868","article-title":"Combined vemurafenib and cobimetinib in BRAF-mutated melanoma","volume":"371","author":"Larkin","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2018.02.009_bb0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1056\/NEJMoa1412690","article-title":"Improved overall survival in melanoma with combined dabrafenib and trametinib","volume":"372","author":"Robert","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2018.02.009_bb0105","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1158\/1078-0432.CCR-10-2346","article-title":"Large-scale analysis of KIT aberrations in Chinese patients with melanoma","volume":"17","author":"Kong","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2018.02.009_bb0110","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/CCO.0b013e32835dafcc","article-title":"C-kit-mutated melanomas: the Chinese experience","volume":"25","author":"Si","year":"2013","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0115","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/35019529","article-title":"Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation","volume":"2","author":"Tanaka","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0120","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cub.2007.02.029","article-title":"Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase","volume":"17","author":"Schmitz","year":"2007","journal-title":"Curr Biol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0125","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrm1401","article-title":"Polo-like kinases and the orchestration of cell division","volume":"5","author":"Barr","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0130","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1158\/0008-5472.CAN-09-4372","article-title":"Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis","volume":"70","author":"Nguyen","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2018.02.009_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067552","article-title":"Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma","volume":"8","author":"Bidkhori","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2018.02.009_bb0140","first-page":"710","article-title":"CDCA5 overexpression is an indicator of poor prognosis in patients with urothelial carcinomas of the upper urinary tract and urinary bladder","volume":"7","author":"Chang","year":"2015","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.humpath.2018.02.009_bb0145","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.18632\/oncotarget.6148","article-title":"Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma","volume":"7","author":"Tokuzen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.humpath.2018.02.009_bb0150","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/JTO.0b013e3181d95dd4","article-title":"The efficacy and safety of BI 2536, a novel Plk-1 inhibitor, in patients with stage IIIB\/IV non\u2013small cell lung cancer who had relapsed after, or failed, chemotherapy: results from an open-label, randomized phase II clinical trial","volume":"5","author":"Sebastian","year":"2010","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0155","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1568009013334241","article-title":"Drug target discovery by gene expression analysis: cell cycle genes","volume":"1","author":"Walker","year":"2001","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.humpath.2018.02.009_bb0160","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1242\/jcs.085431","article-title":"Regulation of sororin by Cdk1-mediated phosphorylation","volume":"124","author":"Dreier","year":"2011","journal-title":"J Cell Sci"},{"key":"10.1016\/j.humpath.2018.02.009_bb0165","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3892\/ijo.2016.3765","article-title":"SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma","volume":"49","author":"Kato","year":"2016","journal-title":"Int J Oncol"},{"key":"10.1016\/j.humpath.2018.02.009_bb0170","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3892\/or.2015.4159","article-title":"Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro","volume":"34","author":"Chiang","year":"2015","journal-title":"Oncol Rep"},{"key":"10.1016\/j.humpath.2018.02.009_bb0175","doi-asserted-by":"crossref","first-page":"635","DOI":"10.15252\/embj.201592532","article-title":"Sororin actively maintains sister chromatid cohesion","volume":"35","author":"Ladurner","year":"2016","journal-title":"EMBO J"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718300509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718300509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T03:35:34Z","timestamp":1535081734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817718300509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":35,"alternative-id":["S0046817718300509"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2018.02.009","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression screening identifies CDCA5 as a potential therapeutic target in acral melanoma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2018.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}