{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:10:35Z","timestamp":1786990235745,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.humpath.2018.06.027","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T13:18:47Z","timestamp":1530364727000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall"],"prefix":"10.1016","volume":"81","author":[{"given":"Marco","family":"Pizzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Brignola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Righi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Agostinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Bertuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpietro","family":"Semenzato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sabattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2018.06.027_bb0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nri1780","article-title":"Microenvironmental niches in the bone marrow required for B-cell development","volume":"6","author":"Nagasawa","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humpath.2018.06.027_bb0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/nyas.12995","article-title":"The functional relationship between hematopoietic stem cells and developing T lymphocytes","volume":"1370","author":"Staal","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.humpath.2018.06.027_bb0015","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nri3702","article-title":"Developmental gene networks: a triathlon on the course to T cell identity","volume":"14","author":"Yui","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humpath.2018.06.027_bb0020","doi-asserted-by":"crossref","unstructured":"Guy-Grand D, Azogui O, Celli S, et al. Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J Exp Med 2003;197:333\u201341.","DOI":"10.1084\/jem.20021639"},{"key":"10.1016\/j.humpath.2018.06.027_bb0025","doi-asserted-by":"crossref","unstructured":"Suzuki K, Oida T, Hamada H, et al. Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis. Immunity 2000;13:691\u2013702.","DOI":"10.1016\/S1074-7613(00)00068-6"},{"key":"10.1016\/j.humpath.2018.06.027_bb0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2011.11.017","article-title":"B-1 B cell development in the fetus and adult","volume":"36","author":"Montecino-Rodriguez","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.humpath.2018.06.027_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098222","article-title":"Nasopharyngeal tonsils (adenoids) contain extrathymic corticothymocytes","volume":"9","author":"Buscone","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2018.06.027_bb0040","doi-asserted-by":"crossref","unstructured":"McClory S, Hughes T, Freud AG, et al. Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest 2012;122:1403\u201315.","DOI":"10.1172\/JCI46125"},{"key":"10.1016\/j.humpath.2018.06.027_bb0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1309\/M8V2-DWPB-DVX1-UBPC","article-title":"Terminal deoxynucleotidyl transferase\u2013positive cells in human tonsils","volume":"116","author":"Strauchen","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2018.06.027_bb0050","first-page":"1139","article-title":"Terminal deoxynucleotidyl transferase\u2013positive cells in spleen, appendix and branchial cleft cysts in pediatric patients","volume":"91","author":"O'Malley","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2018.06.027_bb0055","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/PAS.0000000000000828","article-title":"TdT-positive infiltrate in inflamed pediatric kidney: a potential diagnostic pitfall","volume":"41","author":"Dunlap","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2018.06.027_bb0060","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/1529-0131(200110)44:10<2275::AID-ART390>3.0.CO;2-K","article-title":"Expression of recombination-activating genes and terminal deoxynucleotidyl transferase and secondary rearrangement of immunoglobulin kappa light chains in rheumatoid arthritis synovial tissue","volume":"44","author":"Zhang","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humpath.2018.06.027_bb0065","doi-asserted-by":"crossref","unstructured":"Ohgami RS, Zhao S, Ohgami JK, et al. TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 2012;36:1619\u201328.","DOI":"10.1097\/PAS.0b013e318264e223"},{"key":"10.1016\/j.humpath.2018.06.027_bb0070","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1309\/L3UW-3AE7-L4LB-3QX3","article-title":"Terminal deoxynucleotidyl transferase-positive lymphoid cells in reactive lymph nodes from children with malignant tumors: incidence, distribution pattern, and immunophenotype in 26 patients","volume":"118","author":"Onciu","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2018.06.027_bb0075","doi-asserted-by":"crossref","unstructured":"Pizzi M, Agostinelli C, Righi S, et al. Aberrant expression of CD10 and BCL6 in mantle cell lymphoma. Histopathology 2017;71:769\u201377.","DOI":"10.1111\/his.13286"},{"key":"10.1016\/j.humpath.2018.06.027_bb0080","doi-asserted-by":"crossref","unstructured":"Hoebeke I, De Smedt M, Stolz F, et al. T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34(+)CD38(\u2212)CD7(+) common lymphoid progenitors expressing lymphoid-specific genes. Leukemia 2007; 21:311\u20139.","DOI":"10.1038\/sj.leu.2404488"},{"key":"10.1016\/j.humpath.2018.06.027_bb0085","doi-asserted-by":"crossref","unstructured":"Six EM, Bonhomme D, Monteiro M, et al. A human postnatal lymphoid progenitor capable of circulating and seeding the thymus. J Exp Med 2007;204:3085\u201393.","DOI":"10.1084\/jem.20071003"},{"key":"10.1016\/j.humpath.2018.06.027_bb0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/PAP.0b013e31828d17ec","article-title":"Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma","volume":"20","author":"Ohgami","year":"2013","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.humpath.2018.06.027_bb0095","doi-asserted-by":"crossref","unstructured":"Velankar MM, Nathwani BN, Schlutz MJ, et al. Indolent T-lymphoblastic proliferation: report of a case with a 16-year course without cytotoxic therapy. Am J Surg Pathol 1999;23:977\u201381.","DOI":"10.1097\/00000478-199908000-00017"},{"key":"10.1016\/j.humpath.2018.06.027_bb0100","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00000478-200103000-00018","article-title":"Indolent T-lymphoblastic proliferation: report of a case with an 11-year history and association with myasthenia gravis","volume":"25","author":"Strauchen","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2018.06.027_bb0105","doi-asserted-by":"crossref","unstructured":"Ohgami RS, Sendamarai AK, Atwater SK, et al. Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression. Am J Surg Pathol 2014;38:1298\u2013304.","DOI":"10.1097\/PAS.0000000000000197"},{"key":"10.1016\/j.humpath.2018.06.027_bb0110","unstructured":"Yang F, Liu T, Zhao H, et al. Indolent T-lymphblastic proliferation: report of a case involving the upper aerodigestive tract. Int J Clin Exp Pathol 2014;7:6350\u20136."},{"key":"10.1016\/j.humpath.2018.06.027_bb0115","doi-asserted-by":"crossref","unstructured":"Kansal R, Nathwani BN, Yiakoumis X, et al. Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease. Hum Pathol 2015;46:1057\u201361.","DOI":"10.1016\/j.humpath.2015.03.007"},{"key":"10.1016\/j.humpath.2018.06.027_bb0120","unstructured":"Swerdlow SH, Campo E, Harris NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: International Agency for Research on Cancer; 2017."},{"key":"10.1016\/j.humpath.2018.06.027_bb0125","doi-asserted-by":"crossref","unstructured":"Cattoretti G, Parravicini C, Bonati A, et al. Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues. Eur J Immunol 1989;19:493\u2013500.","DOI":"10.1002\/eji.1830190313"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718302417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718302417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T16:25:19Z","timestamp":1541694319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817718302417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":25,"alternative-id":["S0046817718302417"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2018.06.027","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2018.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}