{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:59:04Z","timestamp":1762005544242,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008003","name":"Korea Institute of Radiological and Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["50476-2018"],"award-info":[{"award-number":["50476-2018"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.humpath.2018.07.004","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T15:17:26Z","timestamp":1531840646000},"page":"176-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The clinical significance of PINX1 expression in papillary thyroid carcinoma"],"prefix":"10.1016","volume":"81","author":[{"given":"JiHoon","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanghee","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Hui","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Suk","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunhoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kyung","family":"Myung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2018.07.004_bb0005","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMc1507622","article-title":"South Korea's Thyroid-Cancer \"Epidemic\"--turning the tide","volume":"373","author":"Ahn","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2018.07.004_bb0010","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1001\/jama.295.18.2164","article-title":"Increasing incidence of thyroid cancer in the United States, 1973-2002","volume":"295","author":"Davies","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.humpath.2018.07.004_bb0015","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1210\/jc.2005-0987","article-title":"BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer","volume":"90","author":"Xing","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humpath.2018.07.004_bb0020","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nrendo.2011.142","article-title":"Molecular genetics and diagnosis of thyroid cancer","volume":"7","author":"Nikiforov","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.humpath.2018.07.004_bb0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1586\/14737159.8.1.83","article-title":"Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis","volume":"8","author":"Nikiforova","year":"2008","journal-title":"Expert Rev Mol Diagn"},{"issue":"Suppl. 2","key":"10.1016\/j.humpath.2018.07.004_bb0030","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1038\/modpathol.2008.10","article-title":"Thyroid carcinoma: molecular pathways and therapeutic targets","volume":"21","author":"Nikiforov","year":"2008","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2018.07.004_bb0035","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.7544491","article-title":"The RNA component of human telomerase","volume":"269","author":"Feng","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.humpath.2018.07.004_bb0040","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1126\/science.1138596","article-title":"Protein composition of catalytically active human telomerase from immortal cells","volume":"315","author":"Cohen","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.humpath.2018.07.004_bb0045","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","article-title":"Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity","volume":"11","author":"Counter","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.humpath.2018.07.004_bb0050","doi-asserted-by":"crossref","first-page":"66267","DOI":"10.18632\/oncotarget.11411","article-title":"PinX1: structure, regulation and its functions in cancer","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.humpath.2018.07.004_bb0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(01)00538-4","article-title":"The Pin2\/TRF1-interacting protein PinX1 is a potent telomerase inhibitor","volume":"107","author":"Zhou","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2018.07.004_bb0060","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1172\/JCI43452","article-title":"The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice","volume":"121","author":"Zhou","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humpath.2018.07.004_bb0065","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/sj.onc.1207832","article-title":"Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma","volume":"24","author":"Kondo","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2018.07.004_bb0070","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/j.1349-7006.2010.01560.x","article-title":"Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma","volume":"101","author":"Cai","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.humpath.2018.07.004_bb0075","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1475-2867-14-46","article-title":"Reduced expression of PinX1 correlates to progressive features in patients with prostate cancer","volume":"14","author":"Shi","year":"2014","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.humpath.2018.07.004_bb0080","doi-asserted-by":"crossref","first-page":"21406","DOI":"10.18632\/oncotarget.4011","article-title":"PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-kappaB-dependent transcription","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.humpath.2018.07.004_bb0085","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12943-015-0332-2","article-title":"PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-kappaB\/MMP-9 signaling pathway","volume":"14","author":"Shi","year":"2015","journal-title":"Mol Cancer"},{"key":"10.1016\/j.humpath.2018.07.004_bb0090","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/path.4163","article-title":"The telomere\/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas","volume":"229","author":"Qian","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2018.07.004_bb0095","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.canlet.2014.07.012","article-title":"The telomere\/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas","volume":"353","author":"Tian","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2018.07.004_bb0100","first-page":"6952","article-title":"PinX1 is up-regulated and associated with poor patients' survival in gliomas","volume":"8","author":"Bai","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.humpath.2018.07.004_bb0105","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4143\/crt.2015.362","article-title":"TERT promoter mutations and tumor persistence\/recurrence in papillary thyroid cancer","volume":"48","author":"Myung","year":"2016","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.humpath.2018.07.004_bb0110","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1476-4598-12-148","article-title":"PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16\/cyclin D1 pathway","volume":"12","author":"Liu","year":"2013","journal-title":"Mol Cancer"},{"key":"10.1016\/j.humpath.2018.07.004_bb0115","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1158\/0008-5472.CAN-05-1069","article-title":"High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival","volume":"65","author":"Reedijk","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2018.07.004_bb0120","doi-asserted-by":"crossref","first-page":"22293","DOI":"10.1073\/pnas.0907781106","article-title":"Alterations of the Notch pathway in lung cancer","volume":"106","author":"Westhoff","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2018.07.004_bb0125","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1158\/0008-5472.CAN-09-4645","article-title":"Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma","volume":"70","author":"Hanlon","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2018.07.004_bb0130","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1084\/jem.20110198","article-title":"Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway","volume":"208","author":"Viatour","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.humpath.2018.07.004_bb0135","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1182\/blood-2005-01-0355","article-title":"Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies","volume":"106","author":"Zweidler-McKay","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2018.07.004_bb0140","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature09999","article-title":"A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia","volume":"473","author":"Klinakis","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2018.07.004_bb0145","doi-asserted-by":"crossref","first-page":"40924","DOI":"10.1074\/jbc.M112.405837","article-title":"The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses","volume":"287","author":"Bauer","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2018.07.004_bb0150","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/carcin\/bgt098","article-title":"SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer","volume":"34","author":"Khongkow","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.humpath.2018.07.004_bb0155","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s13238-013-3054-5","article-title":"Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics","volume":"4","author":"Liu","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.humpath.2018.07.004_bb0160","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/ncb2590","article-title":"Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin","volume":"14","author":"Min","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.humpath.2018.07.004_bb0165","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.cell.2012.10.047","article-title":"The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism","volume":"151","author":"Sebastian","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2018.07.004_bb0170","article-title":"TERT promoter mutation and its association with clinicopathological features and prognosis of papillary thyroid cancer: a meta-analysis","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.humpath.2018.07.004_bb0175","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1089\/thy.2015.0488","article-title":"Prognostic significance of TERT promoter mutations in papillary thyroid carcinomas in a BRAF(V600E) mutation-prevalent population","volume":"26","author":"Lee","year":"2016","journal-title":"Thyroid"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718302612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718302612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:35:23Z","timestamp":1758645323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817718302612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":35,"alternative-id":["S0046817718302612"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2018.07.004","relation":{},"ISSN":["0046-8177"],"issn-type":[{"type":"print","value":"0046-8177"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The clinical significance of PINX1 expression in papillary thyroid carcinoma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2018.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}