{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:40:43Z","timestamp":1787852443446,"version":"build-2784847793"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.humpath.2018.08.001","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T06:46:29Z","timestamp":1534401989000},"page":"187-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Refractory inflammatory bowel disease: is there a role for Epstein-Barr virus? A case-controlled study using highly sensitive Epstein-Barr virus\u2013encoded small RNA1 in situ hybridization"],"prefix":"10.1016","volume":"82","author":[{"given":"Maryam Kherad","family":"Pezhouh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Adam","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Borzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogechukwu","family":"Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Westerhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa M.","family":"Parian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Lazarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lysandra","family":"Voltaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2018.08.001_bb0005","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.suc.2015.07.006","article-title":"Inflammatory bowel disease: historical perspective, epidemiology, and risk factors","volume":"95","author":"Malik","year":"2015","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.humpath.2018.08.001_bb0010","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1053\/j.gastro.2008.09.053","article-title":"Current directions in IBD therapy: what goals are feasible with biological modifiers?","volume":"135","author":"Sandborn","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humpath.2018.08.001_bb0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.7869\/tg.258","article-title":"Biologicals in treatment of acute ulcerative colitis","volume":"36","author":"Ghoshal","year":"2015","journal-title":"Trop Gastroenterol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0020","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4240\/wjgs.v8.i5.363","article-title":"Inflammatory bowel disease surgery in the biologic era","volume":"8","author":"Ferrari","year":"2016","journal-title":"World J Gastrointest Surg"},{"key":"10.1016\/j.humpath.2018.08.001_bb0025","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ajg.2014.45","article-title":"Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy","volume":"109","author":"Vester-Andersen","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0030","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jmv.1890390415","article-title":"Evidence of persistent measles virus infection in Crohn's disease","volume":"39","author":"Wakefield","year":"1993","journal-title":"J Med Virol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0035","first-page":"558","article-title":"The role of infection in inflammatory bowel disease: initiation, exacerbation and protection","volume":"11","author":"Lidar","year":"2009","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.humpath.2018.08.001_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcv.2010.09.011","article-title":"Epstein-Barr virus replication linked to B cell proliferation in inflamed areas of colonic mucosa of patients with inflammatory bowel disease","volume":"50","author":"Sankaran-Walters","year":"2011","journal-title":"J Clin Virol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0045","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/j.1572-0241.1999.01148.x","article-title":"Epstein-Barr virus infection of the colon with inflammatory bowel disease","volume":"94","author":"Yanai","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0050","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.20161846","article-title":"Human immunity against EBV\u2014lessons from the clinic","volume":"214","author":"Tangye","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.humpath.2018.08.001_bb0055","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/JVI.70.5.3286-3289.1996","article-title":"Detection of the latent form of Epstein-Barr virus DNA in the peripheral blood of healthy individuals","volume":"70","author":"Decker","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0060","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/infdis\/161.5.833","article-title":"The switch between latency and replication of Epstein-Barr virus","volume":"161","author":"Miller","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humpath.2018.08.001_bb0065","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr virus: 40 years on","volume":"4","author":"Young","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.humpath.2018.08.001_bb0070","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0602-594","article-title":"Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus","volume":"8","author":"Borza","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.humpath.2018.08.001_bb0075","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jmv.1890380306","article-title":"Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction","volume":"38","author":"Wakefield","year":"1992","journal-title":"J Med Virol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0080","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/DCR.0b013e31827cd02c","article-title":"Inflammatory bowel disease exacerbation associated with Epstein-Barr virus infection","volume":"56","author":"Dimitroulia","year":"2013","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.humpath.2018.08.001_bb0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0002-9440(10)64516-6","article-title":"Distribution and phenotype of Epstein-Barr virus\u2013infected cells in inflammatory bowel disease","volume":"157","author":"Spieker","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0090","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12026-015-8737-y","article-title":"Differential cellular localization of Epstein-Barr virus and human cytomegalovirus in the colonic mucosa of patients with active or quiescent inflammatory bowel disease","volume":"64","author":"Ciccocioppo","year":"2016","journal-title":"Immunol Res"},{"key":"10.1016\/j.humpath.2018.08.001_bb0095","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.dld.2017.03.011","article-title":"Epstein-Barr virus\u2013positive mucocutaneous ulcer in Crohn's disease. A condition to consider in immunosuppressed IBD patients","volume":"49","author":"Juan","year":"2017","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.humpath.2018.08.001_bb0100","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.3748\/wjg.v21.i6.1915","article-title":"Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement","volume":"21","author":"Ciccocioppo","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0105","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2796.2010.02220.x","article-title":"Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything","volume":"267","author":"Loewendorf","year":"2010","journal-title":"J Intern Med"},{"key":"10.1016\/j.humpath.2018.08.001_bb0110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/rmv.1780","article-title":"Switching of EBV cycles between latent and lytic states","volume":"24","author":"Murata","year":"2014","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jmv.22258","article-title":"Longitudinal analysis of frequency and reactivity of Epstein-Barr virus\u2013specific T lymphocytes and their association with intermittent viral reactivation","volume":"84","author":"Vogl","year":"2012","journal-title":"J Med Virol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0120","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/jmv.24331","article-title":"Anti-TNFalpha therapy for inflammatory bowel diseases is associated with Epstein-Barr virus lytic activation","volume":"88","author":"Lapsia","year":"2016","journal-title":"J Med Virol"},{"key":"10.1016\/j.humpath.2018.08.001_bb0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1053\/gast.2002.30328","article-title":"Epstein-Barr virus\u2013positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine","volume":"122","author":"Dayharsh","year":"2002","journal-title":"Gastroenterology"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718303058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817718303058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T20:56:20Z","timestamp":1604782580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817718303058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":25,"alternative-id":["S0046817718303058"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2018.08.001","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Refractory inflammatory bowel disease: is there a role for Epstein-Barr virus? A case-controlled study using highly sensitive Epstein-Barr virus\u2013encoded small RNA1 in situ hybridization","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2018.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}