{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:16:07Z","timestamp":1791821767716,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.humpath.2019.12.006","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T02:05:08Z","timestamp":1578362708000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Uterine inflammatory myofibroblastic tumors in pregnant women with and without involvement of the placenta: a study of 6 cases with identification of a novel TIMP3-RET fusion"],"prefix":"10.1016","volume":"97","author":[{"given":"E. Heidi","family":"Cheek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Numrah","family":"Fadra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory A.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime I.","family":"Davila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Sukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Uckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Keeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Halling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Torres-Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kenneth","family":"Schoolmeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2019.12.006_bb0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/15227950590961180","article-title":"Intraplacental choriocarcinoma: experience from a tertiary referral center and relationship with infantile choriocarcinoma","volume":"24","author":"Sebire","year":"2005","journal-title":"Fetal Pediatr Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0010","first-page":"508","article-title":"Maternal melanoma metastatic to the placenta: a case report and review of the literature","volume":"121","author":"Baergen","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2019.12.006_bb0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/PGP.0000000000000378","article-title":"Endometrial stromal neoplasm in the placenta: report of a case and review of the literature","volume":"37","author":"Heller","year":"2018","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0020","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/archderm.134.6.711","article-title":"Congenital melanocytic nevi with placental infiltration by melanocytes: a benign condition that mimics metastatic melanoma","volume":"134","author":"Ball","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00004347-199807000-00008","article-title":"Hepatic (hepatocellular) adenoma of the placenta: a study of four cases","volume":"17","author":"Khalifa","year":"1998","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0030","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/PGP.0000000000000175","article-title":"Inflammatory myofibroblastic tumor of the placenta: a report of a novel lesion in 2 patients","volume":"34","author":"Banet","year":"2015","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/PGP.0000000000000323","article-title":"ALK-rearranged inflammatory Myofibroblastic tumor of the placenta, with observations on site of origin","volume":"36","author":"Schoolmeester","year":"2017","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0040","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/PAS.0000000000001044","article-title":"Inflammatory myofibroblastic tumor associated with the placenta: short tandem repeat genotyping confirms uterine site of origin","volume":"42","author":"Ladwig","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0045","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1097\/PAS.0000000000000909","article-title":"Inflammatory myofibroblastic tumors of the female genital tract are under-recognized: a low threshold for ALK immunohistochemistry is required","volume":"41","author":"Pickett","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0050","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/PAS.0000000000000801","article-title":"Uterine inflammatory myofibroblastic tumors frequently harbor ALK fusions with IGFBP5 and THBS1","volume":"41","author":"Haimes","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0055","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ejogrb.2015.07.003","article-title":"Inflammatory myofibroblastic tumour: unexpected finding on placental examination","volume":"194","author":"Saeed","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0060","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.pathol.2018.05.008","article-title":"ALK-rearranged inflammatory myofibroblastic tumour of placental membranes","volume":"50","author":"Squires","year":"2018","journal-title":"Pathology"},{"key":"10.1016\/j.humpath.2019.12.006_bb0065","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/modpathol.2017.69","article-title":"Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum","volume":"30","author":"Bennett","year":"2017","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0070","doi-asserted-by":"crossref","first-page":"122","DOI":"10.5858\/arpa.2017-0575-RA","article-title":"Inflammatory myofibroblastic tumor in female genital tract","volume":"143","author":"Shukla","year":"2019","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2019.12.006_bb0075","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1177\/0300060518780873","article-title":"Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report","volume":"46","author":"Takahashi","year":"2018","journal-title":"J Int Med Res"},{"key":"10.1016\/j.humpath.2019.12.006_bb0080","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/JTO.0b013e318209edb9","article-title":"Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH","volume":"6","author":"Yi","year":"2011","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0085","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jmoldx.2018.03.007","article-title":"Development and verification of an RNA sequencing (RNA-Seq) assay for the detection of gene fusions in tumors","volume":"20","author":"Winters","year":"2018","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.humpath.2019.12.006_bb0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.humpath.2019.12.006_bb0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/PAS.0000000000000330","article-title":"Inflammatory myofibroblastic tumor of the uterus: clinical and pathologic review of 10 cases including a subset with aggressive clinical course","volume":"39","author":"Parra-Herran","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0100","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/humrep\/14.11.2844","article-title":"Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy","volume":"14","author":"Nisolle","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.humpath.2019.12.006_bb0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/pgmj.45.519.57","article-title":"The luteo-placental shift, the guardian of pre-natal life","volume":"45","author":"Csapo","year":"1969","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.humpath.2019.12.006_bb0110","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1196\/annals.1335.004","article-title":"Mechanisms underlying \"functional\" progesterone withdrawal at parturition","volume":"1034","author":"Brown","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.humpath.2019.12.006_bb0115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF01606522","article-title":"Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy","volume":"419","author":"Kawaguchi","year":"1991","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0120","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/PAS.0b013e318287779c","article-title":"Cell cycle regulatory markers in uterine atypical leiomyoma and leiomyosarcoma: immunohistochemical study of 68 cases with clinical follow-up","volume":"37","author":"Mills","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0125","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1097\/PAS.0000000000001120","article-title":"ALK is a specific diagnostic marker for inflammatory myofibroblastic tumor of the uterus","volume":"42","author":"Mohammad","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0130","doi-asserted-by":"crossref","first-page":"24320","DOI":"10.18632\/oncotarget.4462","article-title":"Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening","volume":"6","author":"Lee","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.humpath.2019.12.006_bb0135","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1158\/1078-0432.CCR-09-0802","article-title":"Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population","volume":"15","author":"Rodig","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2019.12.006_bb0140","doi-asserted-by":"crossref","unstructured":"Tate JG, Bamford S, Jubb HC, et al. COSMIC: the catalogue of somatic mutations in cancer. Nucleic Acids Res 2019; 47, D941-D7.","DOI":"10.1093\/nar\/gky1015"},{"key":"10.1016\/j.humpath.2019.12.006_bb0145","doi-asserted-by":"crossref","first-page":"33577","DOI":"10.1074\/jbc.M605604200","article-title":"Structure and chemical inhibition of the RET tyrosine kinase domain","volume":"281","author":"Knowles","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humpath.2019.12.006_bb0150","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/PAS.0000000000000404","article-title":"Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement","volume":"39","author":"Antonescu","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0155","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/PAS.0000000000001083","article-title":"ALK-rearranged tumors are highly enriched in the STUMP subcategory of uterine tumors","volume":"43","author":"Devereaux","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/PAS.0b013e318200cfd5","article-title":"Epithelioid inflammatory myofibroblastic sarcoma: an aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK","volume":"35","author":"Marino-Enriquez","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0165","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/path.4836","article-title":"ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma","volume":"241","author":"Lee","year":"2017","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2019.12.006_bb0170","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/PGP.0000000000000431","article-title":"Epithelioid inflammatory myofibroblastic sarcoma of the ovary with RANB2-ALK fusion: report of a case","volume":"37","author":"Fang","year":"2018","journal-title":"Int J Gynecol Pathol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817719302357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817719302357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:36:35Z","timestamp":1758645395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817719302357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":34,"alternative-id":["S0046817719302357"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2019.12.006","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uterine inflammatory myofibroblastic tumors in pregnant women with and without involvement of the placenta: a study of 6 cases with identification of a novel TIMP3-RET fusion","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2019.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}