{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:18:50Z","timestamp":1787167130167,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003091","name":"Government of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.humpath.2020.03.011","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T19:45:08Z","timestamp":1585597508000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study"],"prefix":"10.1016","volume":"99","author":[{"given":"Lili","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjie","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1909-0232","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2020.03.011_bib1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.prp.2018.04.011","article-title":"Intravenous leiomyomatosis of the uterus: a clinicopathologic analysis of 13 cases with an emphasis on histogenesis","volume":"214","author":"Tang","year":"2018","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.humpath.2020.03.011_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1126\/science.1208930","article-title":"MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas","volume":"334","author":"Makinen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.humpath.2020.03.011_bib3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.fertnstert.2014.06.040","article-title":"MED12 mutation frequency in unselected sporadic uterine leiomyomas","volume":"102","author":"Heinonen","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.humpath.2020.03.011_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.humpath.2013.08.005","article-title":"MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors","volume":"45","author":"Schwetye","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib5","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/bjc.2016.130","article-title":"MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas","volume":"114","author":"Kampjarvi","year":"2016","journal-title":"Br J Canc"},{"key":"10.1016\/j.humpath.2020.03.011_bib6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s13238-013-3048-3","article-title":"MED12 mutations in human diseases","volume":"4","author":"Wang","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.humpath.2020.03.011_bib7","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.ejca.2015.04.023","article-title":"MED12 and uterine smooth muscle oncogenesis: state of the art and perspectives","volume":"51","author":"Croce","year":"2015","journal-title":"Eur J Canc"},{"key":"10.1016\/j.humpath.2020.03.011_bib8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/modpathol.2012.203","article-title":"MED12 mutations in leiomyosarcoma and extrauterine leiomyoma","volume":"26","author":"Ravegnini","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005850","article-title":"Exome sequencing of uterine leiomyosarcomas identifies frequent mutations in TP53, ATRX, and MED12","volume":"12","author":"Makinen","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1016\/j.humpath.2020.03.011_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41467-017-02602-0","article-title":"Integrative genomic and transcriptomic analysis of leiomyosarcoma","volume":"9","author":"Chudasama","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.humpath.2020.03.011_bib11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yexmp.2017.01.012","article-title":"Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing","volume":"102","author":"Lee","year":"2017","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib12","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/ijc.31129","article-title":"Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways","volume":"142","author":"Cuppens","year":"2018","journal-title":"Int J Canc"},{"key":"10.1016\/j.humpath.2020.03.011_bib13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/his.14007","article-title":"Prevalence of somatic and germline mutations of Fumarate hydratase in uterine leiomyomas from young patients","volume":"76","author":"Liu","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2020.03.011_bib14","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.humpath.2014.05.010","article-title":"Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study","volume":"45","author":"Buza","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pathol.2019.10.009","article-title":"Intravenous leiomyomatosis: molecular analysis of 17 cases","volume":"52","author":"Lu","year":"2020","journal-title":"Pathology"},{"key":"10.1016\/j.humpath.2020.03.011_bib16","series-title":"Enzinger & weiss: soft tissue tumors","author":"Goldblum","year":"2014"},{"key":"10.1016\/j.humpath.2020.03.011_bib17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/jclinpath-2018-205570","article-title":"Recurrent MED12 exon 2 mutations in benign breast fibroepithelial lesions in adolescents and young adults","volume":"72","author":"Pareja","year":"2019","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/PGP.0000000000000127","article-title":"Intravenous leiomyomatosis revisited: an experience of 14 cases at a single medical center","volume":"34","author":"Carr","year":"2015","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib19","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.humpath.2010.10.015","article-title":"Intravenous leiomyomatosis of the uterus: a clinicopathologic study of 18 cases, with emphasis on early diagnosis and appropriate treatment strategies","volume":"42","author":"Du","year":"2011","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tjog.2017.04.017","article-title":"Intravenous leiomyomatosis of the uterus: a clinicopathological analysis of nine cases and literature review","volume":"56","author":"Low","year":"2017","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.humpath.2020.03.011_bib21","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1002\/cncr.31754","article-title":"Loss of ATRX\/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas","volume":"124","author":"Ahvenainen","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2020.03.011_bib22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1365-2559.2007.02699.x","article-title":"Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential","volume":"50","author":"O'Neill","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2020.03.011_bib23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/PAS.0b013e318287779c","article-title":"Cell cycle regulatory markers in uterine atypical leiomyoma and leiomyosarcoma: immunohistochemical study of 68 cases with clinical follow-up","volume":"37","author":"Mills","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/path.5328","article-title":"Intratumour heterogeneity of p53 expression; causes and consequences","volume":"249","author":"Xue","year":"2019","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/his.13282","article-title":"Immunoexpression of p16 in uterine leiomyomas with infarct-type necrosis: an analysis of 35 cases","volume":"71","author":"Ip","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2020.03.011_bib26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00428-018-2292-6","article-title":"Fumarate hydratase (FH) deficiency in uterine leiomyomas: recognition by histological features versus blind immunoscreening","volume":"472","author":"Siegler","year":"2018","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2020.03.011_bib27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/PGP.0000000000000255","article-title":"Frequency and spectrum of MED12 exon 2 mutations in multiple versus solitary uterine leiomyomas from Russian patients","volume":"35","author":"Osinovskaya","year":"2016","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2020.03.011_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/PAT.0b013e328360bf97","article-title":"Mutation status of the mediator complex subunit 12 (MED12) in uterine leiomyomas and concurrent\/metachronous multifocal peritoneal smooth muscle nodules (leiomyomatosis peritonealis disseminata)","volume":"45","author":"Rieker","year":"2013","journal-title":"Pathology"},{"key":"10.1016\/j.humpath.2020.03.011_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.7150\/ijms.21856","article-title":"Analysis of MED12 mutation in multiple uterine leiomyomas in South Korean patients","volume":"15","author":"Lee","year":"2018","journal-title":"Int J Med Sci"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817720300605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817720300605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:36:46Z","timestamp":1758645406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817720300605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":29,"alternative-id":["S0046817720300605"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2020.03.011","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2020.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}