{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:25:55Z","timestamp":1785374755419,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.humpath.2020.09.010","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:28:40Z","timestamp":1601080120000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Morphological correlation of urinary bladder cancer molecular subtypes in radical cystectomies"],"prefix":"10.1016","volume":"106","author":[{"given":"Lisa","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-6133","authenticated-orcid":false,"given":"Alexander J.","family":"Gallan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy F.","family":"Sweis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladell P.","family":"Paner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2020.09.010_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11912-018-0727-5","article-title":"Molecular subtypes of bladder cancer","volume":"20","author":"McConkey","year":"2018","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.humpath.2020.09.010_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3233\/BLC-150037","article-title":"Bladder cancer molecular taxonomy: summary from a consensus meeting","volume":"2","author":"Lerner","year":"2016","journal-title":"Bladder Cancer"},{"key":"10.1016\/j.humpath.2020.09.010_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrc3817","article-title":"Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity","volume":"15","author":"Knowles","year":"2015","journal-title":"Nat Rev Canc"},{"key":"10.1016\/j.humpath.2020.09.010_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev-pathol-012513-104703","article-title":"Origins of bladder cancer","volume":"11","author":"Czerniak","year":"2016","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.humpath.2020.09.010_bib5","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1158\/1078-0432.CCR-12-0077-T","article-title":"A molecular taxonomy for urothelial carcinoma","volume":"18","author":"Sjodahl","year":"2012","journal-title":"Clin Canc Res"},{"key":"10.1016\/j.humpath.2020.09.010_bib6","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1073\/pnas.1318376111","article-title":"Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology","volume":"111","author":"Damrauer","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2020.09.010_bib7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ccr.2014.01.009","article-title":"Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy","volume":"25","author":"Choi","year":"2014","journal-title":"Canc Cell"},{"key":"10.1016\/j.humpath.2020.09.010_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature12965","article-title":"Comprehensive molecular characterization of urothelial bladder carcinoma","volume":"507","author":"Cancer Genome Atlas Research","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2020.09.010_bib9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.cell.2018.07.036","article-title":"Comprehensive molecular characterization of muscle-invasive bladder cancer","volume":"174","author":"Robertson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2020.09.010_bib10","doi-asserted-by":"crossref","first-page":"10957","DOI":"10.1038\/srep10957","article-title":"Biological determinants of bladder cancer gene expression subtypes","volume":"5","author":"Aine","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.humpath.2020.09.010_bib11","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.eururo.2017.03.010","article-title":"Genetic alterations in the molecular subtypes of bladder cancer: illustration in the cancer Genome Atlas dataset","volume":"72","author":"Choi","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.eururo.2015.07.021","article-title":"On molecular classification of bladder cancer: out of one, many","volume":"68","author":"Aine","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.eururo.2019.09.006","article-title":"A consensus molecular classification of muscle-invasive bladder cancer","volume":"77","author":"Kamoun","year":"2020","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib14","doi-asserted-by":"crossref","first-page":"9956","DOI":"10.1002\/jcb.28278","article-title":"Clinical and molecular characteristics of bladder urothelial carcinoma subtypes","volume":"120","author":"Li","year":"2019","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.humpath.2020.09.010_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85902","article-title":"Claudin-low bladder tumors are immune infiltrated and actively immune suppressed","volume":"1","author":"Kardos","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.humpath.2020.09.010_bib16","doi-asserted-by":"crossref","first-page":"80164","DOI":"10.18632\/oncotarget.13284","article-title":"Specific micro-RNA expression patterns distinguish the basal and luminal subtypes of muscle-invasive bladder cancer","volume":"7","author":"Ochoa","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.humpath.2020.09.010_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.eururo.2017.03.030","article-title":"Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy","volume":"72","author":"Seiler","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.eururo.2016.02.056","article-title":"Gene expression profile of the clinically aggressive micropapillary variant of bladder cancer","volume":"70","author":"Guo","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/pin.12187","article-title":"Nested and microcystic variants of urothelial carcinoma displaying immunohistochemical features of basal-like urothelial cells: an immunohistochemical and histopathogenetic study","volume":"64","author":"Mai","year":"2014","journal-title":"Pathol Int"},{"key":"10.1016\/j.humpath.2020.09.010_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00428-017-2190-3","article-title":"FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma","volume":"471","author":"Warrick","year":"2017","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2020.09.010_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.humpath.2018.05.022","article-title":"Micropapillary urothelial carcinoma: evaluation of HER2 status and immunohistochemical characterization of the molecular subtype","volume":"80","author":"Zinnall","year":"2018","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2020.09.010_bib22","series-title":"WHO classification of tumours of the urinary system and male genital organs","year":"2016"},{"key":"10.1016\/j.humpath.2020.09.010_bib23","series-title":"AJCC cancer staging manual","first-page":"1023","year":"2017"},{"key":"10.1016\/j.humpath.2020.09.010_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/path.4847","article-title":"The molecular basis of breast cancer pathological phenotypes","volume":"241","author":"Heng","year":"2017","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2020.09.010_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.eururo.2018.08.027","article-title":"Molecular subtypes of urothelial bladder cancer: results from a meta-cohort analysis of 2411 tumors","volume":"75","author":"Tan","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib26","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.eururo.2018.06.047","article-title":"Targeted DNA and RNA sequencing of paired urothelial and squamous bladder cancers reveals discordant genomic and transcriptomic events and unique therapeutic implications","volume":"74","author":"Hovelson","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib27","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41379-018-0096-5","article-title":"Discordant molecular subtype classification in the basal-squamous subtype of bladder tumors and matched lymph-node metastases","volume":"31","author":"Sjodahl","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2020.09.010_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.eururo.2018.09.003","article-title":"Intratumoral heterogeneity of bladder cancer by molecular subtypes and histologic variants","volume":"75","author":"Warrick","year":"2019","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2020.09.010_bib29","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/bcr2635","article-title":"Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer","volume":"12","author":"Prat","year":"2010","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.humpath.2020.09.010_bib30","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.urolonc.2019.09.025","article-title":"Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer","volume":"37","author":"Genitsch","year":"2019","journal-title":"Urol Oncol"},{"key":"10.1016\/j.humpath.2020.09.010_bib31","doi-asserted-by":"crossref","first-page":"11702","DOI":"10.1038\/s41598-017-11291-0","article-title":"Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer","volume":"7","author":"Thomsen","year":"2017","journal-title":"Sci Rep"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817720301829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817720301829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:37:36Z","timestamp":1758645456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817720301829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":31,"alternative-id":["S0046817720301829"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2020.09.010","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphological correlation of urinary bladder cancer molecular subtypes in radical cystectomies","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2020.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}